The association between periostin and tumor microenvironment: a promising cancer prognostic biomarker and therapeutic target to combat tumor progression and chemoresistance.

Over the past few decades, cancer research has increasingly focused on tumor microenvironment (TME). The TME contains diverse cellular components and secreted factors, including leukocytes, endothelial cells, cancer-associated fibroblasts, and other non-cancerous cells and extracellular matrix proteins. The interactions between tumor cells and microenvironment elements are complex and unpredictable.

Optimization of copper bioremoval from hypersaline environments by the halophilic archaeon Halalkalicoccus sp. Dap5 via response surface methodology.

Copper pollution in hypersaline environments poses a significant challenge due to the inefficiency of conventional bioremediation strategies under high salinity and metal stress. Halophilic archaea represent a promising solution for heavy metal removal in saline environments due to their biocompatibility and cost-effectiveness. Here, we investigated the copper removal potential of a Halalkalicoccus sp.

Comparison of the Effect of Pressure Massage of Hegu Point with Kunlun-Taixi Points on Pain of Intramuscular Injection in Premature Newborns: A Randomized Clinical Trial.

Background: Performing painful procedures in premature newborns are prevalent. This study compared the effect of the pressure massage of Hegu point with Kunlun-Taixi points on the pain of intramuscular injection in premature newborns.

Materials And Methods: This triple-blind, parallel, clinical trial was conducted in the Neonatal Intensive Care Unit (NICU) of Shahid Rahimi Hospital, Khorramabad, Iran.

Overweight and obesity and its determinants in primary school students: a population-based study from Iran.

The increasing rate of obesity in children and adolescents is alarming, worldwide. This population-based study, conducted in 2024 in Fars Province, Iran, aimed to assess the prevalence of overweight and obesity among primary school students. In the 1st phase, the weight and height of 9853 students who were selected by multi-stage cluster random sampling from 36 districts were measured standardly.

The relationship between maternal emotional self-disclosure and children's anxiety in the post-COVID-19 era.

Background: Following pandemics, anxiety often remains prevalent within families, particularly among mothers, even after the acute phase. Mothers typically engage in increased emotional self-disclosure and interactions with family members, which can promote improved mental health and strengthen family dynamics through the shared expression and management of psychological concerns. This study aimed to determine the relationship between maternal emotional self-disclosure and children's anxiety in the post-COVID-19 era.

All Properties of Infertility Microbiome in a Review Article.

Background: The microbiome is crucial for many physiological processes, including immunity, metabolism, and reproduction.

Aims: This review aims to contribute to a detailed understanding of the microbiome of the genital tract, which can lead to better management of dysbiosis and reproductive disorders.

Methods: Data from the four international information databases Medline, Scopus, Embase, and Google Scholar.

Synthetic photoplethysmogram (PPG) signal generation using a genetic programming-based generative model.

Nowadays, photoplethysmograph (PPG) technology is being used more often in smart devices and mobile phones due to advancements in information and communication technology in the health field, particularly in monitoring cardiac activities. Developing generative models to generate synthetic PPG signals requires overcoming challenges like data diversity and limited data available for training deep learning models. This paper proposes a generative model by adopting a genetic programming (GP) approach to generate increasingly diversified and accurate data using an initial PPG signal sample.

The rs2275738 variant of the adiponectin receptor 1 gene is associated with biopsy-proven nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is a significant health issue worldwide. This study investigated the effect of the adiponectin receptor 1 gene () polymorphism on susceptibility to NAFLD. Data from 330 participants, including 165 biopsy-proven NAFLD patients and 165 healthy controls, were collected.

PeptiHub: a curated repository of precisely annotated cancer-related peptides with advanced utilities for peptide exploration and discovery.

Peptihub (https://bioinformaticscollege.ir/peptihub/) is a meticulously curated repository of cancer-related peptides (CRPs) that have been documented in scientific literature. A diverse collection of CRPs is included in the PeptiHub, showcasing a spectrum of effects and activities.

Improving the quality of clinical training in maternal and neonatal health in undergraduate nursing students: a participatory action research.

Background: Improving the quality of clinical training is synonymous with accomplishing nursing education goals and improving the quality of nursing care. This study aimed to improve the quality of clinical training in Maternal and Neonatal Health (MNH) in nursing students.

Methods: This action research was conducted in two cycles from June 2017 to June 2018.

Non-destructive test-based assessment of uniaxial compressive strength and elasticity modulus of intact carbonate rocks using stacking ensemble models.

The uniaxial compressive strength (UCS) and elasticity modulus (E) of intact rock are two fundamental requirements in engineering applications. These parameters can be measured either directly from the uniaxial compressive strength test or indirectly by using soft computing predictive models. In the present research, the UCS and E of intact carbonate rocks have been predicted by introducing two stacking ensemble learning models from non-destructive simple laboratory test results.

The effect of topical 0.5% humic acid gel on male rats with skin ulcer.

Background: Humic derivatives have antibacterial and anti-inflammatory properties.

Aim: This study aimed to assess the experimental wound-healing effect of 0.5% humic acid gel.

Effects of Satureja Khuzestanica supplementation on glycemic indices and lipid profile in type 2 diabetes patients: a randomized controlled clinical-trial.

Background: Several studies showed the hypoglycemic and hypolipidemic effects of Satureja Khuzestanica (SK) in animal models. This study aimed to determine the effect of SK supplementation on glycemic and lipid outcomes of patients with type 2 diabetes mellitus (T2DM).

Methods: The study was designed as a double-blind, placebo-controlled, randomized clinical trial using block randomization.

Effects of non-tuberculous mycobacteria on BCG vaccine efficacy: A narrative review.

The bacterial pathogen is responsible for the ongoing global tuberculosis (TB) epidemic. Bacille Calmette-Guérin (BCG), the only currently approved TB vaccine, is successful in preventing disseminated disease in newborns. However, it has a variable efficacy against pulmonary TB in adults.

Falling and rising in the vortex of cancer: children's adaptation with cancer: a qualitative study.

Background: Cancer is a considerable health problem worldwide and the second leading cause of death in children. It has many physical, psychological, and social consequences for children and their families. The ability to adapt to cancer plays a vital role in the recovery and quality of life of affected children.

Understanding the performance of RHO type zeolite membrane for CH/N separation based on molecular dynamics and deep neural network methods.

This study shows a molecular dynamics (MD) simulation study on the performance of the RHO zeolite membrane for separating nitrogen from methane/nitrogen gas mixtures. The contamination of natural gas, predominantly composed of methane, with nitrogen diminishes its value. Zeolite membranes offer promising prospects for gas separation due to their stability, rigid pore structure, and molecular sieving properties.

Evaluation of quality of life and associated factors in patients with intertrochanteric femoral fracture.

Background: Intertrochanteric fracture is a common injury among the elderly, causing fundamental lifestyle derangements, influencing the patients' social and psychological functioning. We aimed to study the quality of life (QoL) and its different parameters in patients with this type of injury.

Materials And Methods: In this cross-sectional study, all patients hospitalized with intertrochanteric fracture aged above 50 from 2020 to 2022 at the Shahid Beheshti Hospital in Babol, Iran, were included.

Simulated eye height impacts size perception differently depending on real-world posture.

Changes in perceived eye height influence visually perceived object size in both the real world and in virtual reality. In virtual reality, conflicts can arise between the eye height in the real world and the eye height simulated in a VR application. We hypothesized that participants would be influenced more by variation in simulated eye height when they had a clear expectation about their eye height in the real world such as when sitting or standing, and less so when they did not have a clear estimate of the distance between their eyes and the real-life ground plane, e.

Different Modification Methods of Poly Methyl Methacrylate (PMMA) Bone Cement for Orthopedic Surgery Applications.

In clinical practice, bone defects that occur alongside tumors, infections, or other bone diseases present significant challenges in the orthopedic field. Although autologous and allogeneic grafts are introduced as common traditional remedies in this field, their applications have a series of limitations. Various approaches have been attempted to treat large and irregularly shaped bone defects; however, their success has been less than optimal due to a range of issues related to material and design.

Environment assisted quantum model for studying RNA-DNA-error correlation created due to the base tautomery.

The adaptive mutation phenomenon has been drawing the attention of biologists for several decades in evolutionist community. In this study, we propose a quantum mechanical model of adaptive mutation based on the implications of the theory of open quantum systems. We survey a new framework that explain how random point mutations can be stabilized and directed to be adapted with the stresses introduced by the environments according to the microscopic rules dictated by constraints of quantum mechanics.