RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.

Background: Triple negative breast cancer (TNBC), the most aggressive subtype of breast cancer, is characterized by a high incidence of brain metastasis (BrM) and a poor prognosis. As the most lethal form of breast cancer, BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment strategies. Recent evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis (BCBrM), but the underlying mechanisms are far from being fully elucidated.

Expression dynamics of periodic transcripts during cancer cell cycle progression and their correlation with anticancer drug sensitivity.

Background: The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms, among which transcriptional regulation is one of the most important components. Alternative splicing dramatically expands the regulatory network by producing transcript isoforms of genes to exquisitely control the cell cycle. However, the patterns of transcript isoform expression in the cell cycle are unclear.

Propane-Trapping Ultramicroporous Metal-Organic Framework in the Low-Pressure Area toward the Purification of Propylene.

The propane (CH)-trapping adsorption behavior is considered as a potential performance to directly produce high-purity propylene (CH). Herein, we report an ultramicroporous Mn-based metal-organic framework () with a reverse CH-selective behavior in the low-pressure area. The pore structure of this material possesses more electronegative aromatic benzene rings for the stronger binding affinity to CH, and the material shows outstanding reverse ideal adsorbed solution theory (IAST) selectivity values.

Microporous Metal-Organic Framework with a Completely Reversed Adsorption Relationship for C Hydrocarbons at Room Temperature.

As a new type of porous material, metal-organic frameworks (MOFs) have been widely studied in gas adsorption and separation, especially in C hydrocarbons. Considering the stronger interaction between the unsaturated molecules and the metal sites, and the smaller molecular size of unsaturated molecules, the usual relationship of affinities and adsorption capacities among C hydrocarbons in most common MOFs is CH > CH > CH. Herein, a unique microporous metal-organic framework, (activated ), with a completely reversed adsorption relationship for C hydrocarbons (CH > CH > CH) has been successfully synthesized, which breaks the traditional concept of the adsorption relationship of MOFs for C hydrocarbons.

Aerobic Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid over Holey 2 D Mn O Nanoflakes from a Mn-based MOF.

The aerobic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA), a promising renewable monomer to produce bio-based polymers such as polyethylene furanoate (PEF), has recently emerged as the subject of increasing interest. Here, holey 2 D Mn O nanoflakes were obtained by a facile thermal treatment of a Mn-based metal-organic framework (MOF) precursor. The structural and morphological properties of the nanoflakes were characterized by powder XRD, FTIR, SEM and TEM to explore the formation process.