Publications by authors named "Erica Cognolato"
Introduction: Magnetic Resonance-guided Laser interstitial Thermal Therapy (MR-gLiTT) has established itself as a minimally invasive neurosurgical approach for the treatment of various pediatric brain lesions, including tumors and epilepsy.
Research Question: The work is likely to focus on evaluating the efficacy, safety and applicability of MR-gLiTT while investigating its potential to minimize surgical risks, shorten recovery time and improve patient outcomes.
Material And Methods: This paper presents the results of a survey conducted in three leading italian pediatric hospitals to investigate the use of MR-gLiTT in pediatric patients with neurosurgical conditions.
Objective: To investigate the Italian experience on the surgical and radiosurgical treatment of drug-resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011-2021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques.
Methods: We collected pseudo-anonymized patient's data with at least 12 months of follow-up. Surgical outcome was defined according to Engel classification of seizure outcome.
Objective: Cerebral cavernous malformations (CCMs) are cerebral vascular lesions that occasionally occur with seizures. We present a retrospective case series from IRCCS Gaslini Children's Hospital, a systematic review, and meta-analysis of the literature with the goal of elucidating the post-surgery seizure outcome in children with CCMs.
Methods: a retrospective review of children with cavernous malformation related epilepsy who underwent surgery at Gaslini Children's Hospital from 2005 to 2022 was conducted.
Comparison of Qualitative and Quantitative Analyses of MR-Arterial Spin Labeling Perfusion Data for the Assessment of Pediatric Patients with Focal Epilepsies.
Diagnostics (Basel)
March 2022
Article Synopsis
- * In a study involving 65 children with focal epilepsy, including 26 with brain lesions and 39 with normal MRIs, hypoperfusion areas were identified using these methods, with specific z-score thresholds set to assess their potential link to SOZ.
- * Results showed that quantitative analyses (AI-CBF and cCBF) significantly outperformed qualitative assessments
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series.
Front Neurol
October 2021
Magnetic resonance-guided laser interstitial thermal therapy (MR-gLiTT) is a novel minimally invasive treatment approach for drug-resistant focal epilepsy and brain tumors. Using thermal ablation induced by a laser diode implanted intracranially in a stereotactic manner, the technique is highly effective and safe, reducing the risk associated with more traditional open surgical approaches that could lead to increased neurological morbidity. Indications for MR-gLiTT in pediatric epilepsy surgery include hypothalamic hamartoma, tuberous sclerosis complex, cavernoma-related epilepsy, SEEG-guided seizure onset zone ablation, corpus callosotomy, periventricular nodular heterotopia, mesial temporal lobe epilepsy, and insular epilepsy.
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- Glioblastoma (GBM) is the most common and dangerous type of brain tumor in adults.*
- Researchers studied how a gene called EfnA5 is controlled in glioblastoma cells using a mouse model, finding that a protein named Bmi1 plays a big role in this process.*
- They discovered that targeting the EfnA5 signaling pathway might help develop new treatments for GBM.*