Preoperative Computed Tomography Features as Predictors of Malignancy and Survival in Canine Adrenal Tumours.

As computed tomography (CT) becomes more commonly used in clinical practice for staging and surgical planning of dogs with adrenal tumours, there remain few reports on CT characteristics of malignant adrenal tumours and none that correlate imaging findings with survival. This retrospective study attempts to evaluate preoperative CT characteristics that are associated with malignancy and those that may be associated with shorter survival in dogs with surgically addressed adrenal tumours. CT scans performed at a single tertiary care facility were examined by a single blinded radiologist, and the findings were correlated with histopathology results as well as short- and long-term survival.

Case Report: Adverse reaction to butorphanol in a Collie homozygous for the () mutation.

Certain dog breeds, particularly herding breeds like Collies, are predisposed to drug sensitivity due to the (previously known as ) mutation, which disrupts P-glycoprotein (P-gp) function. This mutation impairs drug efflux at the blood-brain barrier, leading to increased susceptibility to neurotoxic effects. While adverse reactions to P-gp substrate drugs such as macrocyclic lactones and chemotherapeutics are well documented, opioid sensitivity remains poorly understood.

Preoperative septic peritonitis, hypotension, and reason for surgery are risk factors for small intestine dehiscence in dogs: a directed acyclic graph approach.

Objective: To evaluate risk factors for postoperative intestinal dehiscence, adjusting for potential confounders identified through directed acyclic graphs (DAGs).

Methods: A retrospective cohort study was conducted of dogs undergoing small intestinal surgery at a private referral center between July 2011 and July 2024. Directed acyclic graphs were used to identify risk factors, confounders, and mediators, with regression models developed to adjust for these confounders.

Laparoscopic ultrasonography identifies more liver lesions in dogs compared to transabdominal ultrasonography.

Objective: To describe the use of laparoscopic ultrasound (LUS) for evaluation of the liver in dogs with clinical liver disease and to compare the findings of LUS to transabdominal ultrasound (TUS).

Methods: 8 client-owned dogs presenting for laparoscopic liver biopsies due to clinical liver disease were enrolled. All dogs underwent TUS, and liver lesions were identified, localized, and quantified per presumed liver lobe.

Retrospective evaluation of the influence of phenoxybenzamine pretreatment on intraoperative cardiovascular variables in dogs with pheochromocytoma.

Objective: To compare cardiovascular outcomes in dogs undergoing adrenalectomy for pheochromocytoma with and without phenoxybenzamine pretreatment.

Animals: A total of 65 medical records from dogs at 5 veterinary hospitals.

Procedure: Records from January 2004 to December 2021 were evaluated for systolic, mean, and diastolic arterial pressures; numbers of hypertensive and hypotensive episodes; highest and lowest systolic arterial pressure differences; dose and duration of phenoxybenzamine; and presence of intraoperative arrhythmias.

elution of amikacin, cefazolin, gentamicin, ampicillin/sulbactam, and meropenem from a commercially available calcium sulfate delivery kit.

Introduction: The use of implantable antibiotic beads has become a frequent treatment modality for the management of surgical site infections in human and veterinary medicine. The objective of this study is to describe the elution kinetics of five antibiotics from a commercially available calcium sulfate antibiotic delivery kit. A secondary goal was to compare elution concentrations with minimal inhibitory concentrations (MIC) for commonly encountered bacteria from the University of Florida's veterinary microbiology laboratory database.

Ultrasound-guided retromammillary injections in dogs: a feasibility, descriptive and anatomical study.

Objective: To evaluate the feasibility of an ultrasound-guided technique targeting the medial branches of the dorsal ramus of the spinal nerves (DRSN) by injecting a dye solution at the caudal aspect of the base of lumbar mammillary processes [i.e. the retromammillary (RM) space].

Adrenal tumors treated by adrenalectomy following spontaneous rupture carry an overall favorable prognosis: retrospective evaluation of outcomes in 59 dogs and 3 cats (2000-2021).

Objective: To conduct a retrospective multi-institutional study reporting short- and long-term outcomes of adrenalectomy in patients presenting with acute hemorrhage secondary to spontaneous adrenal rupture.

Animals: 59 dogs and 3 cats.

Methods: Medical records of dogs and cats undergoing adrenalectomy between 2000 and 2021 for ruptured adrenal masses were reviewed.

Laparoscopic ultrasonography of the liver is feasible and safe in dogs.

Objective: To describe the feasibility and technique for performing laparoscopic ultrasound (LUS) of the liver in dogs.

Animals: 12 client-owned dogs presenting for elective laparoscopic surgery from January 1, 2022, to October 31, 2022.

Methods: Laparoscopic exploration and LUS of the liver were performed in all dogs.

Biomechanical comparison of canine median sternotomy closure using suture tape and orthopedic wire cerclage.

Objective: To compare the mechanical properties of suture tape and orthopedic wire cerclage in an ex vivo canine median sternotomy model.

Study Design: Ex vivo.

Animals: Twelve large-breed canine cadaveric sternums.

Geometric, landmark-guided technique reduces tissue trauma, surgery time, and subjective difficulty for canine peripheral lymphadenectomies: an educational crossover study.

Objective: To compare the effect of a geometric, landmark-guided lymphadenectomy (LL) approach to peripheral lymph nodes (LNs) on successful LN identification, surgical time, tissue trauma, and ease of LN identification compared to standard lymphadenectomy (SL) and methylene blue-guided lymphadenectomy (MBL).

Sample: 18 adult, mixed-breed canine cadavers operated on by 7 veterinarians and 5 fourth-year veterinary students between July 23 and October 12, 2022.

Methods: Participants were provided standardized, publicly available materials regarding the anatomy and surgical techniques for SL of 3 peripheral lymphocentrums: superficial cervical, axillary (ALN), and superficial inguinal (SILN).

Multiple biliary duct hamartomas in a cat resulting in a hepatic mass: A case report.

A 13-year-old, male neutered domestic short-haired cat was diagnosed with multiple biliary duct hamartomas after liver lobectomy for a suspected malignant hepatic mass. Distinguishing ultrasonographic findings included a lobular, mostly well-defined, heterogeneous, predominantly hyperechoic, left hepatic mass. Computed tomography (CT) confirmed the presence of a lobular, well-defined, fluid to soft tissue attenuating, heterogeneously hypoenhancing left divisional hepatic mass.

Acellular fish skin may be used to facilitate wound healing following wide surgical tumor excision in dogs: a prospective case series.

Objective: To prospectively evaluate clinical outcomes using acellular fish skin grafts (FSGs) for the management of complete wound healing by secondary intention after wide surgical excision of skin tumors in dogs.

Animals: 5 dogs undergoing wide surgical excision of skin tumors on the distal extremity.

Clinical Presentation And Procedures: FSGs were applied to surgical wound beds following wide excision of the tumor.

Client perceptions improve with collaborative care when managing dogs with cancer: a Collaborative Care Coalition study.

Objective: Collaboration between primary care veterinarians (pcVets) and veterinary oncologists is common for dogs diagnosed with cancer, but no data exist that explore dog owner utilization and perceptions of collaborative care. The objectives were to describe dog owner perceptions of the value of collaborative veterinary cancer care and identify drivers of a positive collaborative care experience between the pcVet and oncologic specialists.

Sample: 890 US dog owners who had pets diagnosed with cancer in the past 3 years.

Endoscopic application of fibrin glue may be a feasible method of treatment for postintubation tracheal lacerations in cats.

Objective: To determine the feasibility of endoscopic application of fibrin glue for the treatment of experimentally induced postintubation tracheal laceration (PITL) in feline cadavers. The secondary objective was to determine the optimal technique for application of the fibrin glue.

Animals: 20 feline cadavers (n = 10 fresh and 10 frozen).

Superficial anatomic landmarks can be used to triangulate the location of canine peripheral lymphocentrums: superficial cervical, axillary, and superficial inguinal.

Objective: To utilize the geometry of superficial anatomic landmarks to guide incisional location and orientation for peripheral lymphadenectomy, document deep anatomic landmarks for lymphocentrum identification, and develop novel surgical approaches to the superficial cervical, axillary, and superficial inguinal lymphocentrums in dogs.

Animals: 12 canine cadavers.

Procedures: 2 cadavers were used for a pilot investigation to determine optimal body positioning, select superficial anatomic landmarks for lymphocentrum identification, and evaluate novel surgical approaches to the 3 lymphocentrums.

Complications associated with iliosacral lymphadenectomy in dogs with metastatic apocrine gland anal sac adenocarcinoma.

Objective: To report intraoperative and immediate postoperative complications associated with removal of metastatic iliosacral lymph nodes in dogs with apocrine gland anal sac adenocarcinoma.

Animals: There were 136 client-owned dogs in the study.

Procedure: Retrospective multi-institutional study.

A narrative review on the role of carbon nanoparticles in oncology.

The lymphatic system is the first site of metastasis for most tumors and is a common reason for the failure of cancer therapy. The lymphatic system's anatomical properties make it difficult to deliver chemotherapy agents at therapeutic concentrations while avoiding systemic toxicity. Carbon nanoparticles offer a promising alternative for identifying and transporting therapeutic molecules.

What Is Your Diagnosis?

In collaboration with the American College of Veterinary Radiology.

Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006-2020).

Background: While rare, multiple individual case reports have described mixed thyroid tumours in dogs containing both epithelial and mesenchymal neoplastic components.

Objectives: In this retrospective case series, we describe the clinical presentation, treatment and outcome of 14 dogs of canine thyroid tumours with concurrent mesenchymal and epithelial neoplastic populations.

Methods: Fourteen cases were retrospectively abstracted from nine institutions.

Acellular fish skin grafts for the management of wounds in dogs and cats: 17 cases (2019-2021).

Objective: To report the clinical outcomes of the use of acellular fish skin grafts (FSGs) for the management of complex soft tissue wounds of various etiologies in dogs and cats.

Animals: 13 dogs and 4 cats with complex wounds treated with FSGs between February 2019 and March 2021.

Procedures: Medical records were reviewed for information regarding cause, location, size of the wound, management techniques, complications, and clinical outcomes.

Collaborative Care Improves Treatment Outcomes for Dogs with Chronic Otitis Externa: A Collaborative Care Coalition Study.

The purpose of this retrospective study was to compare outcome measures in dogs treated by a primary care veterinarian (pcDVM) before referral and after seeking collaboration with a board-certified veterinary dermatologist (BCVD) for cases of severe recurrent chronic otitis externa. Medical records of 65 client-owned dogs were retrospectively reviewed, and data were obtained regarding treatment history, referral timeframe, recurrence rate, clinical signs, and resolution of signs. The median number of otitis recurrences while under the care of the pcDVM was 4 (range 1-40) versus collaborative BCVD care of 2 (P < .

Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine.

Background And Objectives: 7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial µ-opioid receptor (MOR) agonist, 7-HMG is a potent and full MOR agonist. It is produced from mitragynine by cytochrome P450 (CYP) 3A, a drug-metabolizing CYP isoform predominate in the liver that is also highly expressed in the intestine.

Outcomes of dogs undergoing immediate or delayed surgical treatment for gastrointestinal foreign body obstruction: A retrospective study by the Society of Veterinary Soft Tissue Surgery.

Objective: To evaluate gastrointestinal injury and outcomes between dogs treated with immediate surgical intervention vs those treated with delayed surgical intervention for gastrointestinal foreign body obstruction (GIFBO).

Study Design: Retrospective cohort study.

Sample Population: Client-owned dogs (n = 855) from five referral hospitals.