Publications by authors named "Elisa Contreras"
Antibodies and helper T cells play important roles in SARS-CoV-2 infection and vaccination. We sequenced B- and T-cell receptor repertoires (BCR/TCR) from the blood of 251 infectees, vaccinees, and controls to investigate whether features of these repertoires could predict subjects' SARS-CoV-2 neutralizing antibody titer (NAbs), as measured by enzyme-linked immunosorbent assay (ELISA). We sequenced recombined immunoglobulin heavy-chain (IGH), TCRβ (TRB), and TCRδ (TRD) genes in parallel from all subjects, including select B- and T-cell subsets in most cases, with a focus on their hypervariable CDR3 regions, and correlated this AIRRseq data with demographics and clinical findings from subjects' electronic health records.
View Article and Find Full Text PDFEvaluation of sample pooling for the detection of SARS-CoV-2 in a resource-limited setting, Dominican Republic.
Enferm Infecc Microbiol Clin (Engl Ed)
January 2023
Introduction: COVID-19 is a worldwide public health threat. Diagnosis by RT-PCR has been employed as the standard method to confirm viral infection. Sample pooling testing can optimize the resources by reducing the workload and reagents shortage, and be useful in laboratories and countries with limited resources.
View Article and Find Full Text PDFEvaluation of sample pooling for the detection of SARS-CoV-2 in a resource-limited setting, Dominican Republic.
Enferm Infecc Microbiol Clin (Engl Ed)
July 2021
Article Synopsis
- COVID-19 poses a global health risk, and RT-PCR testing is the standard method for diagnosis, but sample pooling can help optimize resources by reducing workloads and reagent shortages in labs, especially in resource-limited settings.
- The study evaluated SARS-CoV-2 detection by pooling samples, creating 210 pools from 245 samples, each containing a positive case to test the efficiency of this method.
- Findings suggest that pooling up to three samples for SARS-CoV-2 testing is effective without compromising the sensitivity of RT-PCR, while larger pools may lead to a higher chance of false negatives.
Evaluation of sample pooling for the detection of SARS-CoV-2 in a resource-limited setting, Dominican Republic.
Enferm Infecc Microbiol Clin
January 2023
Introduction: COVID-19 is a worldwide public health threat. Diagnosis by RT-PCR has been employed as the standard method to confirm viral infection. Sample pooling testing can optimize the resources by reducing the workload and reagents shortage, and be useful in laboratories and countries with limited resources.
View Article and Find Full Text PDFKohlschütter-Tönz Syndrome - Report of an additional case.
J Clin Exp Dent
April 2013
Kohlschütter-Tönz Syndrome is a rare disorder clinically characterized by amelogenesis imperfecta, epilepsy and progressive mental deterioration. We present an additional case of this syndrome of a nine year-old boy who was referred by pigmented teeth. The mental deterioration was associated with speech delay, impulsive behavior, attention-deficit/hyperactivity disorder, and learning problems.
View Article and Find Full Text PDFPrimary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America.
Med Oral Patol Oral Cir Bucal
May 2012
Objective: The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM).
Study Design: Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67.
Results: The mean age was 58 years and 14 cases were female.
Epithelioid osteosarcoma of the mandible: a rare case with unusual immunoprofile.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
February 2008
A 42-year-old woman presented a large, nontender, quickly progressive mass in the left mandible. Radiograph showed extensive destruction of the angle, posterior body, and ramus of the left side of the mandible. The patient was surgically treated by hemimandibulectomy.
View Article and Find Full Text PDFOral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis.
Med Oral Patol Oral Cir Bucal
September 2007
Article Synopsis
- Oral melanoacanthoma (MA) is a rare, benign pigmented lesion in the mouth, with its cause still unclear but likely related to a reactive process, typically found in younger black females.
- Oral melanotic macule (MM), another pigmented lesion, appears as a small brown-to-black spot, primarily affecting middle-aged females, and its cause is also uncertain.
- A biopsy is important to differentiate between MA, MM, and other similar oral lesions, as demonstrated by four case studies of these conditions in Caucasian and Latin American mestizo patients, including a unique case of MA in a Caucasian boy.
Angiomyolipoma of the upper lip: case report and review of the literature.
Med Oral Patol Oral Cir Bucal
March 2007
Angiomyolipoma (AML) is a hamartomatous growth that usually affects the kidney. One third of patients with AML present with manifestations of tuberous sclerosis. Oral AML is rare with only 6 cases reported in the English-language literature.
View Article and Find Full Text PDFOral melanoacanthosis (melanoachantoma): report of a case and review of the literature.
Med Oral Patol Oral Cir Bucal
May 2005
Article Synopsis
- Oral melanoacanthosis (MA) is a rare pigmented lesion in the mouth, similar to cutaneous melanoacanthoma.
- It typically affects black females and commonly appears in areas like the buccal mucosa, lip, palate, and gingiva.
- Diagnosis requires a biopsy due to its non-specific appearance, as it needs to be distinguished from other melanocytic lesions, including melanoma.