Defect-Driven Redox Interplay on Anatase TiO: Surface-Structure Dependent Activation for CO Hydrogenation Catalysis.

Titanium dioxide (TiO) is one of the most extensively studied oxides as an active catalyst or catalyst support, particularly in energy and environmental applications, but the atomistic mechanisms governing its dynamic response to reactive environments and their correlation to reactivity remain largely elusive. Using in situ environmental transmission electron microscopy (ETEM), synchrotron X-ray diffraction (XRD), ambient-pressure X-ray photoelectron spectroscopy (AP-XPS), temperature-programmed reduction (TPR), reactivity measurements, and theoretical modeling, we reveal the dynamic interplay between oxygen loss and replenishment of anatase TiO under varying reactive conditions. Under H exposure, anatase TiO undergoes surface reduction via lattice oxygen loss, forming TiO.

Host sphingolipids support liver stage development.

During the asymptomatic liver stage resides within a parasitophorous vacuole (PV) that protects the parasite from immune clearance while also restricting nutrient exchange with its host cell. Although it is known that must scavenge resources from its environment, the specific nutrients sequestered and the mechanisms for transporting them to the PV are poorly understood, particularly during the liver stage. In this study, we investigated the role of host lipids and discovered that sphingolipids are critical for both liver stage development and invasion.

Preoperative immunonutrition for patients who undergo primary cytoreductive surgery for ovarian cancer.

Objective: The role of preoperative immunonutrition interventions in patients with gynecologic malignancies has not been well studied.

Methods: We performed a prospective observational study to assess the feasibility of a preoperative immunonutrition supplementation plan in patients with advanced ovarian cancer who underwent primary cytoreductive surgery between August 2019 and November 2022. Patients were encouraged to consume the provided immunonutrition supplement at each meal for up to 7 days prior to surgery.

Covalent inhibition of Ubc13 impairs global protein synthesis.

The ubiquitin-conjugating enzyme 13 (Ubc13) has an essential function and putative role in artemisinin activity against . Ubc13 conjugates lysine 63-linked ubiquitin (K63-Ub) to proteins, but the role of this modification in remains largely unknown. Herein, we characterize and deploy NSC697923 to interrogate PfUbc13 function.