USP21-EGFR-Lyn axis drives NSCLC progression and therapeutic potential of USP21 inhibition.

Non-small cell lung cancer (NSCLC) is a highly aggressive malignancy frequently driven by oncogenic mutations in the epidermal growth factor receptor (EGFR). Although EGFR-tyrosine kinase inhibitors (EGFR-TKIs) have shown clinical efficacy, challenges such as limited response duration and intrinsic mechanisms-such as EGFR amplification-can affect therapeutic outcomes. This study investigates the role of the USP21-EGFR-Lyn axis in NSCLC progression, identifying USP21 as a key regulator of EGFR and Lyn stability.

Multimodal AI model for preoperative prediction of axillary lymph node metastasis in breast cancer using whole slide images.

In breast cancer management, predicting axillary lymph node (ALN) metastasis using whole-slide images (WSIs) of primary tumor biopsies is a challenging and underexplored task for pathologists. We developed METACANS, an multimodal artificial intelligence (AI) model that integrates WSIs with clinicopathological features to predict ALN metastasis. METACANS was trained on 1991 cases and externally validated across five cohorts with a total of 2166 cases.

USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer.

The emerging role of ubiquitin-specific peptidase 21 (USP21) in stabilizing Fra-1 (FOSL1) highlights its involvement in promoting colorectal cancer (CRC) metastasis. Additionally, a reciprocal link between EGFR signaling and Fra-1 activation has been identified, mediated through matrix metalloproteinases (MMPs). However, the functional implications of the USP21-EGFR signaling axis in metastatic CRC (mCRC) are not fully understood.

Does intracranial pressure vary based on external ventricular drainage? A real-world clinical observation study.

Background: External ventricular drains (EVDs) are placed in patients with increased intracranial pressure (ICP) to serve as a cerebrospinal fluid (CSF) pressure flow diverter and ICP monitor. EVD management practice among institutions and practitioners varies greatly, with little evidence supporting ideal ICP recording and CSF drainage practice.

Objective: This study's aim is to determine variations in ICP across 21 min before and after CSF drainage.

Establishment of circular economy by utilising textile industry waste as an adsorbent for textile dye removal.

This study explored the use of waste from the textile industry (silkworm byproducts) as a promising raw feedstock for the production of carbon-based adsorbents (biochar). The silk excreta biochar generated at 600 and 700 °C (referred to as SEB-600 and SEB-700, respectively) were evaluated in terms of their efficacy in adsorbing cationic (methylene blue) and anionic (Congo red) textile dyes. Although the functional groups on the surfaces of SEB-600 and SEB-700 were not significantly different, the specific surface area of SEB-700 was greater than that of SEB-600.

Histopathologic image-based deep learning classifier for predicting platinum-based treatment responses in high-grade serous ovarian cancer.

Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous ovarian carcinoma (HGSOC), but choosing an appropriate treatment for patients hinges on their responsiveness to it. Currently, no available biomarkers can promptly predict responses to platinum-based treatment. Therefore, we developed the Pathologic Risk Classifier for HGSOC (PathoRiCH), a histopathologic image-based classifier.

Thermochemical conversion of silkworm by-product into syngas.

This study explored the valorisation of silkworm by-product, a major by-product of the silk industry (sericulture), which amounts to 16 million tonnes annually. The focus was on transforming waste into energy resources through pyrolysis under CO conditions. In one-stage pyrolysis, the evolution of syngas under N was found to be comparable to that under CO.

Synergistic effects of CO on complete thermal degradation of plastic waste mixture through a catalytic pyrolysis platform: A case study of disposable diaper.

Consumption of diverse plastics has posed an environmental threat because their disposal practices, landfilling and incineration, release toxic chemicals and microplastics into all environmental media. Indeed, heterogeneous matrix of plastic wastes makes them hard to be disposed. As such, this study aimed to introduce an environmentally benign/reliable disposal platform for complete decomposition of plastic wastes.

NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake.

BACKGROUNDMolecular characterization in pediatric papillary thyroid cancer (PTC), distinct from adult PTC, is important for developing molecularly targeted therapies for progressive radioiodine-refractory (131I-refractory) PTC.METHODSPTC samples from 106 pediatric patients (age range: 4.3-19.

Valorization of synthetic textile waste using CO as a raw material in the catalytic pyrolysis process.

Since an invention of synthetic fibers (textiles), our life quality has been improved. However, the cumulative production and disposal of them have perceived as significant since they are not biodegradable and hard to be upcycled/recycled. From washing textiles, microplastics are released into the environment, which are regarded as emerging contaminants.

Clinicopathological features of programmed cell death-1 and programmed cell death-ligand-1 expression in the tumor cells and tumor microenvironment of angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma not otherwise specified.

The expression patterns of programmed cell death-1 (PD-1) and programmed cell death-ligand-1 (PD-L1) and their clinicopathological implications were investigated in peripheral T cell lymphoma (PTCL) including angioimmunoblastic T cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS). PTCL-NOS was further classified into nodal PTCL with follicular helper T cell (Tfh) phenotype ("PTCL-Tfh_new") and "PTCL-NOS_new". PD-1 and PD-L1 expression on tumor cells and reactive immune cells was evaluated using immunohistochemistry.

Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer.

Background: We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC).

Methods: Changes in glycolysis-related molecules and glycolytic activity were evaluated in PD-L1 and PD-L1 NSCLC cells after transfection or knockdown of PD-L1, respectively. Jurkat T-cell activation was assessed after co-culture with NSCLC cells.

MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function.

The MET tyrosine receptor kinase is essential for embryonic development and tissue regeneration by promoting cell survival, proliferation, migration, and angiogenesis. It also contributes to tumor development and progression through diverse mechanisms. Using human cancer cell lines, including Hs746T (-mutated/amplified), H596 (-mutated), and H1993 (-amplified) cells, as well as BEAS-2B bronchial epithelial cells, we investigated whether MET is involved in the regulation of immune checkpoint pathways.

Cancer Panel Assay for Precision Oncology Clinic: Results from a 1-Year Study.

Next-generation sequencing (NGS)-based cancer panel tests are actively being applied in the clinic for precision oncology. Given the importance of NGS panel tests in the palliative clinical setting, it is critical to understand success rates, factors responsible for test failures, and the incidence of clinically meaningful genetic alterations. We performed NGS cancer panel test with tumors from the stomach (n = 234), colorectum (n = 196), and rare tumors (n = 105) from 535 recurrent or metastatic cancer patients for 1 year.

High tumoral PD-L1 expression and low PD-1 or CD8 tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system.

We investigated the clinicopathological role of the PD-1/PD-L1 pathway in primary diffuse large B-cell lymphoma of the central nervous system (PCNS-DLBCL) arising in the immune-privileged site. PD-L1 immunostaining of ≥30% of tumor cells was defined as tPD-L1+, and PD-L1 immunostaining of ≥30% of total cellularity, including tumor and non-tumoral cells, as tmPD-L1+ . PD-1 and CD8 tumor-infiltrating lymphocytes (TILs) were enumerated.

Orange peel valorization by pyrolysis under the carbon dioxide environment.

To valorize biomass waste, pyrolysis of orange peel was mainly investigated as a case study. In an effort to establish a more sustainable thermolytic platform for orange peel, this study particularly employed CO as reactive gas medium. Accordingly, this study laid great emphasis on elucidating the mechanistic role of CO in pyrolysis of orange peel.

Blastic plasmacytoid dendritic cell neoplasm with unusual extracutaneous manifestation: Two case reports and literature review.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy. This disease almost always presents with cutaneous involvement.

Patient Concerns: The 1st patient was a 16-year-old girl who presented with recurrent epistaxis.

Bronchovascular injury associated with clinically significant hemoptysis after CT-guided core biopsy of the lung: Radiologic and histopathologic analysis.

Objective: To evaluate bronchovascular injuries as the causative occurrence for clinically significant hemoptysis after percutaneous transthoracic needle biopsy (PTNB).

Materials And Methods: We included 111 consecutive patients who experienced hemoptysis after cone beam CT (CBCT)-guided PTNB from January 2014 through January 2017. Clinically significant hemoptysis was defined as hemoptysis causing hemodynamic instability or oxygen desaturation greater than 10% of baseline.

Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinoma.

Objectives: Endoplasmic reticulum (ER) stress is associated with tumor development and progression via pro-tumorigenic and anti-tumorigenic effects. However, the clinicopathological implications of the ER stress pathway in non-small cell lung cancer remain unclear. Therefore, we sought to address these issues in this study.

Prognostic implications of tumor-infiltrating macrophages, M2 macrophages, regulatory T-cells, and indoleamine 2,3-dioxygenase-positive cells in primary diffuse large B-cell lymphoma of the central nervous system.

Primary diffuse large B-cell lymphoma of the central nervous system (CNS-DLBCL) is an aggressive disease with a poor prognosis. The status of the tumor immune microenvironment in CNS-DLBCL remains unclear. We investigated the prognostic implications of tumor-associated macrophages (TAMs), regulatory T-cells (Tregs), and indoleamine 2,3-dioxygenase (IDO) cells in primary CNS-DLBCL (n = 114) by immunohistochemical analysis.

Pediatric Case Report on an Interstitial Lung Disease with a Novel Mutation of Successfully Treated with Lung Transplantation.

Mutations of the surfactant protein (SP)-C gene () have been associated with neonatal respiratory distress syndrome (RDS) and childhood interstitial lung disease (ILD). If accurate diagnosis and proper management are delayed, irreversible respiratory failure demanding lung transplantation may ensue. A girl was born at term but was intubated and given exogenous surfactant due to RDS.

WITHDRAWN:Uterine Arteriovenous Malformation Accompanied with a Uterine Stromomyoma.

Ahead of Print article withdrawn by publisher.

MET exon 14 skipping mutation in triple-negative pulmonary adenocarcinomas and pleomorphic carcinomas: An analysis of intratumoral MET status heterogeneity and clinicopathological characteristics.

Objectives: MET mutations leading to exon 14 skipping rarely occur in non-small cell lung cancer (NSCLC). Recently, small molecule inhibitors targeting MET mutations showed clinical benefit. However, the clinicopathological characteristics of NSCLC harboring MET mutations, and the correlation among mutations, protein expression, and gene copy number of MET in NSCLC remain unclear.

Comparative analysis of PD-L1 expression between primary and metastatic pulmonary adenocarcinomas.

Programmed death-ligand 1 (PD-L1) expression in pulmonary adenocarcinomas (pADCs) was implicated in predicting anti-PD-1/PD-L1 therapy efficacy. However, the differential expression of PD-L1 between primary and metastatic pADC remains unclear. Thus, we addressed this issue.

Mucinous Cystadenoma of the Testis: A Case Report with Immunohistochemical Findings.

Mucinous cystadenoma of the testis is a very rare tumor. Herein, we report a case of mucinous cystadenoma arising in the testis of a 61-year-old man, along with a literature review. Computed tomography showed a 2.