Multimodality curative-intent treatment in NSCLC: an unprecedented era of change 2017-2025.

Curative-intent multimodality treatment-combining local treatments such as surgery or radiotherapy with systemic therapy-is the cornerstone of care in stage II-III non-small cell lung cancer (NSCLC). Since 2017, the systemic therapy backbones with multimodality treatment have undergone a dramatic transformation, driven by a series of pivotal, practice-changing clinical trials. Immunotherapy and targeted therapies, previously confined to the advanced/metastatic setting, are now firmly embedded in curative-intent regimens.

Emergency Department Preparedness in a Mega Mass Casualty Incident While Under Missile Fire: Lessons Learned From Israel on October 7, 2023.

Background: On October 7, 2023, approximately 2,500 Hamas terrorists infiltrated southern Israel from Gaza. Over 1,200 people were killed and 1600 were injured in the largest mass casualty incident (MCI) in Israel's history. Emergency departments (EDs) throughout the country were overwhelmed with patients and working under missile fire.

The Atopic Dermatitis Continuum: An Updated Paradigm for a Common Disorder and a Novel Multipurpose Treatment Option.

Background: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by complex interactions among Staphylococcus aureus colonization and immunologic, genetic, and environmental (SAIGE) triggers. Currently, no single therapy comprehensively addresses all triggers and the full spectrum of AD manifestations, highlighting an unmet need for therapies that simultaneously target all components of the disease continuum.

Methods: An expert panel conducted a structured literature review and developed consensus statements during a meeting in March 2025.

Early Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Implantation.

Background: This study aimed to elucidate the incidence, risk factors, and midterm outcomes associated with hemodynamic valve deterioration (HVD) 1 year after transcatheter aortic valve implantation (TAVI).

Methods: This was a retrospective, single-institution cohort study of consecutive TAVIs from 2012 to 2022. Patients with immediate post-TAVI, 30-day, and 1-year echocardiographic data were included.

Apparent charge reduction in multipolarons crafted one-by-one in monolayer CrBr.

Manipulating electrons opens up emerging synthetic strategies. Multipolaron, as a rare quasiparticle containing multiple excess charges collectively dressed with shared local lattice distortions, provides an ideal medium for electron manipulation, yet remains elusive. Here, with scanning tunneling microscopy, we realize electron multipolarons in monolayer CrBr.