Multimodality curative-intent treatment in NSCLC: an unprecedented era of change 2017-2025.

Curative-intent multimodality treatment-combining local treatments such as surgery or radiotherapy with systemic therapy-is the cornerstone of care in stage II-III non-small cell lung cancer (NSCLC). Since 2017, the systemic therapy backbones with multimodality treatment have undergone a dramatic transformation, driven by a series of pivotal, practice-changing clinical trials. Immunotherapy and targeted therapies, previously confined to the advanced/metastatic setting, are now firmly embedded in curative-intent regimens.

Sustainability in orthodontics: Challenges and opportunities for improving our environmental impact.

Objective: To highlight the potential environmental impact of different aspects of orthodontic care in the United Kingdom, outline the major barriers and challenges to reducing this impact, and summarise the possible action that could help the orthodontic community to tackle the climate change crisis.

Impact: Travel, procurement and supply, material use, waste management, energy use and water consumption within dentistry have a considerable effect on the environment. There are, however, marked knowledge gaps pertaining to the impact of orthodontic treatment.

The NSW Emergency Psychiatry Network.

Emergency Psychiatry is evolving. In an environment that lacks a clear evidence base, and where a constellation of factors is driving up Emergency Department presentation rates and lengths of stay, several stakeholders are working towards and clamouring for change. With the goal of collaborating with such parties, we believe Emergency Psychiatrists should position themselves to establish and advocate for best-practice change in culture, research, clinical care and training, and funding in the provision of mental health crisis care.

The impact of smoking cessation on schizophrenia and major depression.

Objective: This review sought to determine whether quitting smoking behaviour places people with a history of schizophrenia or major depression at risk of worsening symptoms or relapse.

Method: Literature searches of Embase, MEDLINE, the Cochrane Library and PsycINFO.

Results: Six studies involving 735 people diagnosed with schizophrenia, schizoaffective disorder or psychotic disorder did not find significant change in mental health status after quitting smoking.