Publications by authors named "D R Chaple"
Article Synopsis
- Cardiovascular diseases affect 608 million people globally, causing 32% of deaths, and often require combination therapy targeting the RAAS and Neprilysin systems.
- A new multi-target in-silico modeling technique (mt-QSAR) was developed to assess the inhibitory effects on Neprilysin and Angiotensin-converting enzymes, achieving around 90% accuracy using various machine learning algorithms on 983 chemicals.
- The study’s findings, including virtual screening and molecular dynamics simulations, aim to aid in identifying new multi-targeted treatments for cardiovascular conditions.
Azilsartan prevents muscle loss and fast- to slow-twitch muscle fiber shift in natural ageing sarcopenic rats.
Can J Physiol Pharmacol
May 2024
Sarcopenia is a musculoskeletal disease that reduces muscle mass and strength in older individuals. The study investigates the effects of azilsartan (AZL) on skeletal muscle loss in natural sarcopenic rats. Male Sprague-Dawley rats aged 4-6 months and 18-21 months were selected as young-matched control and natural-aged (sarcopenic) rats, respectively.
View Article and Find Full Text PDFCardiovascular diseases (CVD) such as heart failure, stroke, and hypertension affect 64.3 million people worldwide and are responsible for 30% of all deaths. Primary inhibition of the angiotensin-converting enzyme (ACE) is significant in the management of CVD.
View Article and Find Full Text PDFExploring the active constituents of in intervention of novel coronavirus (COVID-19) based on molecular docking method.
Netw Model Anal Health Inform Bioinform
February 2021
Unlabelled: The severe acute respiratory syndrome COVID-19 declared a global pandemic by WHO has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications. We report in this study a molecular docking study of eighteen molecules with the main protease (M) responsible for the replication of SARS-CoV-2 virus.
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