Endocrine Adverse Events of Immune Checkpoint Inhibitors: A Comprehensive Review.

Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy by enhancing T-cell-mediated tumour eradication. However, their use is associated with immune-related adverse events, with endocrinopathies being the most common. Thyroid dysfunction, hypophysitis, primary adrenal insufficiency (PAI), and insulin-dependent diabetes mellitus are well-documented complications.

Clinical Profile, Outcomes, and Predictors of Malignant Pheochromocytoma and Paraganglioma: Insights From a Single-Center Cohort.

Background: Malignant pheochromocytoma and paraganglioma (mPPGL) are not so common and the factors predicting the metastatic behavior are not well understood.

Methods: This retrospective cohort study included 218 patients with PPGL managed at our center over a period of 11 years (2013-2024). The clinical profile and treatment outcomes of patients with mPPGL were studied and were compared with non-metastatic PPGL(non-mPPGL).

Outcomes of open or closed treatment of foot fractures: A database study comparing patients with and without diabetes.

Treatment of ankle and foot fractures in patients with diabetes mellitus (DM) is challenging, and complications may arise. Although much data exists on complication rates in tibial, fibular, and malleolar fractures, there exists a comparable lack of data on complication rates in fractures of the tarsal, metatarsal, and phalanx bones of the foot. Therefore, we aimed to compare post-procedural outcomes after such fractures in diabetic vs non-diabetic patients.

The efficacy of add-on yoga intervention in somatoform pain disorders: An open-label controlled trial.

Background: Patients diagnosed with somatoform pain disorders (SPDs) experience chronic pain without any obvious etiology and repeatedly seek medical help to find some relief from the symptoms.

Aim: In this study, the effect of 24 weeks of add-on yoga therapy was assessed on pain in patients diagnosed with SPDs through an open-label trial.

Materials And Methods: Seventy subjects (42 women) with a group mean age ± standard deviation (SD) of 35.