Increased loading of the lateral knee compartment in the unamputated knee during gait in people with unilateral transfemoral/through-knee amputations.

Aims: People with unilateral transfemoral/through-knee amputations (UTF) are at risk of mechanically mediated contralateral knee osteoarthritis (OA). This study aims to identify the mechanical indicators of the development and progression of unamputated knee OA in the UTF population.

Methods: Level-ground gait data were collected from 14 male traumatic UTF participants and 14 uninjured matched controls using optical motion capture systems and force plates.

Diagnostic Accuracy of Smart Supra Perimetry in Comparison With Standard Automated Perimetry in the Detection of Early Glaucoma.

Prcis: The diagnostic performance for detecting early glaucoma of a supra-threshold and a threshold visual field tests are compared. Their performance was found to be equivalent with the supra-threshold test being faster.

Purpose: To compare the diagnostic accuracy of a supra-threshold and a threshold visual field test in detecting early glaucoma using optical coherence tomography (OCT) as the reference standard.

The biomechanical effect of different spring extension assist mechanisms in mechanical 4-bar polycentric prosthetic knees for unilateral above/through-knee amputees.

Background: Passive prosthetic knees incorporate extension assist mechanisms to enhance the swing phase of the gait cycle for persons with above/through-knee amputations. In conventional polycentric knees using a 4-bar linkage, the extension assist mechanism connects one of the bars to the body of the prosthesis. However, this design introduces a singularity in the spring action delivery, causing the spring to push the knee into flexion beyond a certain angle.

Evaluation of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Criteria in a Multicenter Cohort of Patients With Intravenous Drug Use: A Retrospective Study.

Background: Intravenous drug use (IVDU) significantly increases the risk of infective endocarditis (IE). This study evaluates the 2023 Duke-International Society of Cardiovascular Infectious Diseases (ISCVID) criteria for diagnosing IE in patients with a history of IVDU.

Methods: This multicenter retrospective study evaluates these criteria in a cohort of 205 patients with intravenous drug use (IVDU) history, comparing outcomes with the 2000 modified Duke criteria.

Feasibility of pharmacy-based research opportunity to enhance community testing and surveillance.

Background: Approximately 89% of the US population lives within five miles of a community pharmacy, which provides a network of geographically distributed recruitment nodes for testing and surveillance of infection and disease.

Objectives: Establish feasibility of Pharmacy-based Research Opportunities To Enhance Community Testing and Surveillance in the context of SARS-CoV-2 infection in a community pharmacy setting with University of Kentucky serving as the coordinating center and research hub for sample analysis.

Methods: Two community pharmacies in Kentucky served as community-based recruitment sites to assess SARS-CoV-2 exposure through longitudinal (5 visits over 56 days) collection of nasal swabs and blood samples from subjects.