Diagnostic Accuracy of Smart Supra Perimetry in Comparison With Standard Automated Perimetry in the Detection of Early Glaucoma.

Prcis: The diagnostic performance for detecting early glaucoma of a supra-threshold and a threshold visual field tests are compared. Their performance was found to be equivalent with the supra-threshold test being faster.

Purpose: To compare the diagnostic accuracy of a supra-threshold and a threshold visual field test in detecting early glaucoma using optical coherence tomography (OCT) as the reference standard.

Diagnostic Performance and Repeatability of a Novel Game-Based Visual Field Test for Children.

Purpose: To demonstrate utility of a game-based test ("Caspar's Castle") for the detection of visual field defects in children.

Methods: A validity and reliability study was carried out at Manchester Royal Eye Hospital Pediatric Ophthalmology Outpatients Department. We recruited 108 children with no eye pathology (aged 4-12 years) and examined a single eye with the Caspar's Castle system using either normal thresholds or thresholds artificially adapted to recreate defects to assess diagnostic utility.

Development of a Pediatric Visual Field Test.

Purpose: We describe a pediatric visual field (VF) test based on a computer game where software and hardware combine to provide an enjoyable test experience.

Methods: The test software consists of a platform-based computer game presented to the central VF. A storyline was created around the game as was a structure surrounding the computer monitor to enhance patients' experience.

Normal Threshold Size of Stimuli in Children Using a Game-Based Visual Field Test.

Introduction: The aim of this study was to demonstrate and explore the ability of novel game-based perimetry to establish normal visual field thresholds in children.

Methods: One hundred and eighteen children (aged 8.0 ± 2.

In vivo imaging of cortical vitreous using 1050-nm swept-source deep range imaging optical coherence tomography.

Purpose: To image the cortical vitreous, determine the prevalence of the bursa premacularis and space of Martegiani, and measure the dimensions of the bursa using the new 1050-nm swept-source deep range imaging optical coherence tomography (DRI OCT-1 Atlantis).

Design: Retrospective cross-sectional study.

Methods: One hundred and nineteen consecutive patients (5-100 years) underwent an OCT scan using 1050-nm swept-source deep range imaging optical coherence tomography.

Spatial changes of central field loss in diabetic retinopathy after laser.

Purpose: To explore the spatial distribution of central visual field loss in untreated proliferative diabetic retinopathy (PDR) and to quantify the effect of medium-pulse Optos-guided 20-millisecond Pascal laser treatment on the central field.

Methods: Visual field data (Swedish Interactive Threshold Algorithm 24-2) from 99 eyes (66 patients) with treatment-naive PDR were used to train a self-organizing map (SOM) that classified the defects into nine patterns. Twenty-eight eyes of 23 patients treated with 20-millisecond Pascal retinal laser photocoagulation underwent Optos widefield fundus fluorescein angiography (WF-FFA) at baseline and 3 months after treatment.

A study to assess the feasibility of undertaking a randomized controlled trial of adherence with eye drops in glaucoma patients.

Background: Adherence with therapy could influence the progression of glaucoma and ultimately affect the onset of visual impairment in some individuals. This feasibility study evaluated the measures to be used for a future randomized controlled trial assessing the effects of group-based education on adherence with eye drops.

Methods: People diagnosed with glaucoma within the previous 12 months attending a regional ophthalmology clinic in the North West of England were recruited.

Diagnostic performance of visual field test using subsets of the 24-2 test pattern for early glaucomatous field loss.

Purpose: To explore the diagnostic performance of threshold visual field tests using subsets of the standard 24-2 test pattern in detecting early/moderate glaucomatous field loss.

Methods: Normal (Brusini stage 0, n = 2344) and defective eyes (Brusini stage 2-3, n = 2222) from a database of visual field tests (6696 eyes/3586 patients, SITA standard 24-2 algorithm) were selected and resampled using a bootstrap method. The positive predictive values (PPVs) of each test location were calculated for the resampled datasets with a fail criteria of a single missed stimulus at a pattern deviation probability level of less than 0.

Pilot randomised clinical trial of Pascal TargETEd Retinal versus variable fluence PANretinal 20 ms laser in diabetic retinopathy: PETER PAN study.

Purpose: To investigate the short-term effects of high-density 20-ms laser on macular thickness using Pascal-targeted retinal photocoagulation (TRP) and reduced fluence/minimally-traumatic panretinal photocoagulation (MT-PRP) compared to standard-intensity PRP (SI-PRP) in proliferative diabetic retinopathy (PDR).

Methods: Prospective randomised clinical trial. Treatment-naive PDR was treated with single-session 20-ms Pascal 2500 burns photocoagulation randomised to one of three treatment arms (TRP:MT-PRP:SI-PRP).

Differences in spectral absorption properties between active neovascular macular degeneration and mild age related maculopathy.

This study examines the differences in spectral absorption properties between the maculae of patients with active neovascular macular degeneration and those with early age related maculopathy (ARM). Patients attending for management of neovascular age related macular degeneration (AMD) underwent multispectral imaging with a system comprising of a modified digital fundus camera coupled with a 250-W tungsten-halogen lamp and a liquid crystal fast-tuneable filter. Images were obtained at 8 wavelengths between 496 and 700 nm.

Optos-guided pattern scan laser (Pascal)-targeted retinal photocoagulation in proliferative diabetic retinopathy.

Purpose: To investigate the clinical effects and safety of targeted pattern scan laser (Pascal) retinal photocoagulation (TRP) in proliferative diabetic retinopathy (PDR).

Methods: Prospective and non-randomized study of 28 eyes with treatment-naive proliferative diabetic retinopathy (PDR). Single-session 20-ms-Pascal TRP strategy applied 1500 burns to zones of retinal capillary non-perfusion and intermediate retinal ischaemia guided by wide-field fluorescein angiography (Optos).

Relationships between visual field sensitivity and spectral absorption properties of the neuroretinal rim in glaucoma by multispectral imaging.

Purpose: To investigate the relationship between neuroretinal rim (NRR) differential light absorption (DLA, a measure of spectral absorption properties) and visual field (VF) sensitivity in primary open-angle glaucoma (POAG).

Methods: Patients diagnosed with (n = 22) or suspected of having (n = 7) POAG were imaged with a multispectral system incorporating a modified digital fundus camera, 250-W tungsten-halogen lamp, and fast-tuneable liquid crystal filter. Five images were captured sequentially within 1.

Randomized clinical trial to evaluate the effects of Pascal panretinal photocoagulation on macular nerve fiber layer: Manchester Pascal Study report 3.

Purpose: To investigate the effects of panretinal photocoagulation (PRP) on macular thickness and macular nerve fiber layer thickness in eyes with proliferative diabetic retinopathy.

Methods: Single-center, randomized clinical trial (n = 40 eyes). Proliferative diabetic retinopathy was treated with 1,500 burns given as Pascal 20-millisecond single-session PRP (SS-PRP) or as multiple-session PRP (100 milliseconds, MS-PRP) over a 4-week period.

Blink frequency and duration during perimetry and their relationship to test-retest threshold variability.

Purpose: To describe different patterns of blinking in patients undergoing a visual field test and to establish whether the blink parameters are related to threshold variability.

Methods: Thirty-nine patients with diagnosed or suspected glaucoma were recruited to undertake a perimetric task twice. Blinks were detected with a video eye-tracker system that records at a sampling rate of 60 Hz.

Discus: investigating subjective judgment of optic disc damage.

Purpose: To describe a software package (Discus) for investigating clinicians' subjective assessment of optic disc damage [diagnostic accuracy in detecting visual field (VF) damage, decision criteria, and agreement with a panel of experts] and to provide reference data from a group of expert observers.

Methods: Optic disc images were selected from patients with manifest or suspected glaucoma or ocular hypertension who attended the Manchester Royal Eye Hospital. Eighty images came from eyes without evidence of VF loss in at least four consecutive tests (VF negatives), and 20 images from eyes with repeatable VF loss (VF positives).

Spatial and spectral imaging of retinal laser photocoagulation burns.

Purpose: To correlate in vivo spatial and spectral morphologic changes of short- to long-pulse 532 nm Nd:YAG retinal laser lesions using Fourier-domain optical coherence tomography (FD OCT), autofluorescence (AF), fluorescein angiography (FA), and multispectral imaging.

Methods: Ten eyes with treatment-naive preproliferative or proliferative diabetic retinopathy were studied. A titration grid of laser burns at 20, 100, and 200 milliseconds was applied to the nasal retina and laser fluence titrated to produce four grades of laser lesion visibility: subvisible (SV), barely visible (BV, light-gray), threshold (TH, gray-white), and suprathreshold (ST, white).

Barely visible 10-millisecond pascal laser photocoagulation for diabetic macular edema: observations of clinical effect and burn localization.

Purpose: To investigate the morphologic features and clinical efficacy of barely visible Pascal (Optimedica Corporation) photocoagulation burns in diabetic macular edema (DME) using Fourier-domain optical coherence tomography (FD OCT) and fundus autofluorescence (AF).

Design: Interventional case series.

Methods: Retrospective evaluation of 10 eyes with newly diagnosed DME that underwent barely visible Pascal photocoagulation using an array of 10-microm, 10-millisecond photocoagulation burns.

Single-session vs multiple-session pattern scanning laser panretinal photocoagulation in proliferative diabetic retinopathy: The Manchester Pascal Study.

Objective: To investigate the effects of pattern scanning laser (Pascal; OptiMedica, Santa Clara, California) multispot panretinal photocoagulation given in a single-session (SS-PRP) vs single-spot multiple-session PRP (MS-PRP) on proliferative diabetic retinopathy (PDR).

Methods: Single-center, randomized clinical trial of 40 eyes. Proliferative diabetic retinopathy was treated with a 400-mum spot size in 1500 burns given either as Pascal in 20-millisecond SS-PRP or in 3 sessions (100-millisecond MS-PRP) during a 4-week period.

In vivo laser-tissue interactions and healing responses from 20- vs 100-millisecond pulse Pascal photocoagulation burns.

Objectives: To compare in vivo burn morphologic features and healing responses of Pascal 20- and 100-millisecond panretinal photocoagulation (PRP) burns in proliferative diabetic retinopathy.

Design: Prospective randomized controlled trial with 24 eyes assigned to either 20- or 100-millisecond Pascal PRP. Fundus autofluorescence and Fourier domain optical coherence tomography (FD-OCT) were performed 1 hour and 2 and 4 weeks after treatment.

Monitoring vigilance during perimetry by using pupillography.

PURPOSE. To report and present data on a method for monitoring patient vigilance during a visual field test by using pupillometry. METHODS.

Perimetric sensitivity and response variability in glaucoma with single-stimulus automated perimetry and multiple-stimulus perimetry with verbal feedback.

Purpose: To measure perimetric sensitivity and response variability of glaucomatous patients with single-stimulus automated perimetry (SSAP) and multiple-stimulus perimetry (MSP) with verbal feedback.

Methods: Frequency-of-seeing (FOS) data were collected from the same four visual field locations (normal and reduced sensitivity) in one eye of 10 glaucoma patients, using SSAP and MSP. The SSAP technique was similar to that used in routine clinical perimetry while the MSP technique required the patient to verbally report the positions of the seen stimuli (0-4, with no more than 1 in each quadrant) after each presentation.

Automated analysis of heidelberg retina tomograph optic disc images by glaucoma probability score.

Purpose: To compare the diagnostic performance of the Heidelberg Retinal Tomograph's (HRT; Heidelberg Engineering GmbH, Dossenheim, Germany) glaucoma probability score (GPS), an automated, contour line-independent method of optic disc analysis with that of the Moorfields regression analysis (MRA).

Methods: HRT images were obtained from one eye of 121 patients with glaucoma (median age, 70.2 years; median mean deviation [MD], -3.

Relative risk of progressive glaucomatous visual field loss in patients enrolled and not enrolled in a prospective longitudinal study.

Objective: To establish the relative risk of progressive visual field loss in a sample of glaucomatous eyes enrolled in a prospective longitudinal study vs a matched sample of eyes not enrolled in a study.

Methods: The first visual field records of 66 glaucomatous eyes enrolled in a prospective longitudinal study (mean follow-up time, 3.4 years; mean number of visual field tests, 8.