Study on the targeted regulation of Scutellaria baicalensis leaf on glutamine-glutamate metabolism and glutathione synthesis in the liver of d-gal ageing rats.

Objectives: Scutellaria baicalensis leaf (SLE), the above-ground part of the traditional Chinese medicine Scutellaria baicalensis Georgi, is rich in resources and contains a large number of flavonoids with anti-inflammatory, antioxidant and neuroprotective functions. The present study evaluated the ameliorative effects and related mechanisms of SLE on d-gal-induced ageing rats, providing a theoretical basis for the exploitation of SLE.

Methods: This experiment investigated the mechanism of SLE for anti-ageing by non-targeted metabonomics technology combined with targeted quantitative analysis and molecular biology technology.

Long non-coding RNA MAFG-AS1 promotes proliferation and metastasis of breast cancer by modulating STC2 pathway.

Breast cancer is the most common cancer worldwide. A number of studies proposed that long non-coding RNA plays an essential role in the regulation of invasion and metastasis of various forms of malignancy, including lung cancer, gastric cancer, and bladder cancer. In this study, a long non-coding RNA(LncRNA) MAFG-AS1 was explored in detail to understand the significance in the etiology of breast cancer.

Synthetic MRI with quantitative mappings for identifying receptor status, proliferation rate, and molecular subtypes of breast cancer.

Objective: To investigate whether quantitative parameters of synthetic magnetic resonance imaging (MRI) can be used to differentiate among receptor status, proliferation rate, and molecular subtypes in patients with breast cancer.

Materials And Methods: This retrospective study included patients with suspicious breast lesions who underwent breast MR examinations (including synthetic MRI) from May 2019 to Oct 2020. Quantitative parameters of synthetic MRI, including T1, T2, and proton density (PD) in the breast lesions before and after (T1-Gd, T2-Gd, and PD-Gd) contrast agent injection were obtained.

Clinicopathological and molecular genomic features of monomorphic epitheliotropic intestinal T-cell lymphoma in the Chinese population: a study of 20 cases.

Background: Monomorphic epitheliotropic T-cell lymphoma (MEITL) is an aggressive non-Hodgkin lymphoma with a high fatality rate. This study was aimed to explore the clinicopathological and molecular genetic features of MEITL in the Chinese population.

Methods: A retrospective analysis was performed based on the clinical manifestations and pathological features of 20 Chinese MEITL.

The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1.

Breast cancer is the leading cause of cancer-related death in women around the world. It is urgently needed to identify genes associated with tumorigenesis and prognosis, as well as to elucidate the molecular mechanisms underlying the oncogenic process. Long noncoding RNAs (lncRNAs) are widely involved in the pathological and physiological processes of organisms and play an important role as oncogenes or tumor suppressor genes, affecting the development and progression of tumors.

Optically Active Porous Microspheres Consisting of Helical Substituted Polyacetylene Prepared by Precipitation Polymerization without Porogen and the Application in Enantioselective Crystallization.

A novel chiral acetylenic monomer derived from cholic acid was synthesized and structurally characterized. The monomer underwent precipitation polymerization in tetrahydrofuran/-heptane mixed solvent with [Rh(nbd)Cl] as catalyst. Without adding porogen, porous microspheres were successfully prepared in a high yield (>80 wt %).

Helical substituted polyacetylene-derived fluorescent microparticles prepared by precipitation polymerization.

This article reports the first fluorescent microparticles (MPs, approximately 600 nm in diameter) constructed using helical substituted polyacetylene and prepared via a precipitation polymerization approach. The MPs judiciously combine this interesting helical conjugated acetylene, fluorescent material and polymeric particles in one entity. The monomer containing a dansyl group undergoes precipitation polymerization in butanone/n-heptane mixed solvent, with (nbd)Rh(+) B(-) (C6 H5 )4 as a catalyst.