extract improves insulin tolerance and pancreatic islet function in ageing and HFD-induced diabetic mice.

Siamenoside I (SI) is the sweetest compound isolated from fruit. The extremely low natural abundance limits its application. We have previously produced an M3 extract (containing 68.

Reg2 treatment is protective but the induced Reg2 autoantibody is destructive to the islets in NOD mice.

Regenerating family protein 2 (Reg2) is a trophic factor which stimulates β-cell replication and resists islet destruction. However, Reg2 also serves as an islet autoantigen, which makes it complicated to judge the effectiveness in treating diabetes. How Reg2 treatment behaves in non-obese diabetic (NOD) mice is to be investigated.