J Epidemiol Community Health
September 2025
Background: Population aging has led to accelerated decline in pulmonary function, rising prevalence of depressive symptoms, and cognitive impairment, posing significant public health challenges. Although epidemiological evidence links poorer pulmonary function to subsequent cognitive decline, the pathways driving this relationship are not fully understood. We therefore investigated whether depressive symptoms mediate this relationship in older Chinese adults.
View Article and Find Full Text PDFPurpose: This study aims to investigate the protective effects of esketamine on lung injury in rat models of chronic obstructive pulmonary disease (COPD) under mechanical ventilation. The focus is on serum exosome miRNA profiles through RNA sequencing and bioinformatics analysis.
Methods: Male Sprague-Dawley rats were categorized into four groups: Control (C), COPD model (M), COPD model + saline (MS), and COPD model + esketamine (MK).
Objective: To evaluate the effect of the individualized positive end-expiratory pressure (PEEP) lung protection ventilation strategy by combining driving pressure (ΔP) and pulmonary ultrasound (LUS)-based titration on lung function and postoperative cognitive function in patients with chronic obstructive pulmonary disease (COPD) during laparoscopic surgery.
Methods: A total of 108 patients with COPD undergoing laparoscopic gastrointestinal surgery under general anesthesia were included in this study. They were randomly divided into three groups (n = 36): traditional volume ventilation group (Group C), fixed PEEP 5 cmHO group (Group P), and ΔP combined with LUS-based PEEP titration in the resuscitation room group (Group T).