Foxk1 and Foxk2 promote cardiomyocyte proliferation and heart regeneration.

Promoting endogenous cardiomyocyte proliferation is a promising strategy for cardiac repair. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration. Here, we identify Foxk1 and Foxk2 as key regulators of cardiomyocyte proliferation, whose expression declines during postnatal heart development.

Pharmacologically inducing regenerative cardiac cells by small molecule drugs.

Adult mammals, unlike some lower organisms, lack the ability to regenerate damaged hearts through cardiomyocytes (CMs) dedifferentiation into cells with regenerative capacity. Developing conditions to induce such naturally unavailable cells with potential to proliferate and differentiate into CMs, that is, regenerative cardiac cells (RCCs), in mammals will provide new insights and tools for heart regeneration research. In this study, we demonstrate that a two-compound combination, CHIR99021 and A-485 (2C), effectively induces RCCs from human embryonic stem cell-derived TNNT2 CMs in vitro, as evidenced by lineage tracing experiments.

The interval time for the St. Thomas cardioplegia solution in mitral valve surgeries.

Background: There is a lack of consensus on the appropriate St. Thomas cardioplegia solution interval for cardiac surgeries. The objective of this study was to determine a safe cardioplegia interval.

Analysis of employee diligence and mining of behavioral patterns based on portrait portrayal.

With the deepening of enterprise digital construction, the portrait portrayal based on employee behaviors has gradually become a research focus. Currently, the employee's portrait portrayal mostly has the problems of simple means, low efficiency, limited solving ability, etc., making the results more one-sided.