Publications by authors named "Chiara Fumagalli"
Enhanced recovery after surgery (ERAS) programs have been shown, in many types of operations and surgical specialties, to be the gold standard of perioperative patient care. This statement is sustained by strong evidence on the significant reduction of postoperative morbidity, duration of hospitalization, health-related costs, nurse working load, and improved patient satisfaction when the programs are fully implemented. However, in some fields of surgery, the evidence is still moderate because data collection and systematic research has begun few years ago.
View Article and Find Full Text PDFEnhanced recovery pathways (ERPs) are evidence-based, multimodal strategies designed to promote early recovery and to optimize surgical outcomes. While extensively implemented in elective surgery, their adaptation to emergency general surgery (EGS) raises challenges due to patient instability and limited preoperative time. The study aimed to evaluate the adherence to each ERPs item and the impact on short-term outcomes in patients undergoing emergency general surgery.
View Article and Find Full Text PDFArticle Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
Article Synopsis
- Non-operative management (NOM) for uncomplicated acute appendicitis is a viable alternative to surgery, with this study comparing outpatient (outNOM) and inpatient (inNOM) approaches.
- The study involved 668 patients, showing that outNOM was non-inferior to inNOM in terms of the rate of appendectomies within 30 days and had a shorter average hospital stay (0.89 days vs. 3.94 days).
- Though some outNOM patients visited the emergency department unexpectedly, overall safety and effectiveness of outpatient NOM were supported, indicating a need for further research.
Introduction: A persistent primitive trigeminal artery (PTA) is the most common type of fetal carotid-basilar anastomosis in adulthood; however, its prevalence is low and estimated between 0.1% and 0.7% in angiographic studies.
View Article and Find Full Text PDFCytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model.
World J Gastroenterol
December 2005
Aim: To evaluate the interplay between gliadin and LoVo cells and the direct effect of gliadin on cytoskeletal patterns.
Methods: We treated LoVo multicellular spheroids with digested bread wheat gliadin in order to investigate their morphology and ultrastructure (by means of light microscopy and scanning electron microscopy), and the effect of gliadin on actin (phalloidin fluorescence) and the tight-junction protein occludin and zonula occluden-1.
Results: The treated spheroids had deep holes and surface blebs, whereas the controls were smoothly surfaced ovoids.