Lonidamine alleviates inflammation and tissue remodeling in a mouse model of eosinophilic chronic sinusitis: A single-cell transcriptomics study.

Background: Eosinophilic chronic sinusitis (ECRS) is a refractory condition resistant to therapies and prone to relapse. Hexokinase 2 (HK2), a key glycolysis enzyme, regulates inflammation but its role in ECRS is unclear.

Methods: An ECRS mouse model was established using intranasal administration of papain.