Self-healing hydrogels loaded with selenium nanoparticles/chitosan/cellulose nanofibers as carriers of mesenchymal stem cells for diabetic wound healing.

As one of the most serious chronic complications of diabetes mellitus, diabetic foot ulcers (DFUs) have a complex pathogenesis involving multiple factors such as persistent hyperglycemia-induced microangiopathy, chronic inflammatory state and oxidative stress injury. Regenerative medicine strategies of stem cells have brought new hope for DFUs treatment, among which adipose-derived mesenchymal stem cells (ADSCs) have attracted much attention due to their easy accessibility, multidirectional differentiation potential and paracrine function. However, excessive accumulation of reactive oxygen species (ROS) due to the high-glucose microenvironment can trigger mitochondrial dysfunction and premature senescence of ADSCs, which greatly reduce their therapeutic efficacy.

In situphotothermal-chemical dynamics synergistic enhancement of anti-tumor effect based on phycocyanin multifunctional nanosystem.

Colorectal cancer (CRC) treatment remains challenged by the systemic toxicity, non-specific targeting and high recurrence rates associated with conventional therapeutic approaches. In this study, a tumor microenvironment (TME)-activated multifunctional nanoplatform, PDTF@CM, was developed for synergistic treatment by integrating photothermal therapy (PTT), chemodynamic therapy (CDT) and chemotherapy (CT). The platform comprises a phycocyanin core with doxorubicin (DOX) and a metal-phenolic network shell, cloaked with CT26 tumor cell membrane for homologous targeting.

A biomimetic manganese-phycocyanin nanodrug-carrying system and its sonodynamic-immunological anti-tumor therapy.

Cutaneous melanoma is characterized by malignant proliferation, high aggressiveness, high metastasis, rapid recurrence, and low survival rate; therefore, research on its treatment is vital. In this study, a novel nano system combining sonodynamics and immunotherapy for cutaneous melanoma treatment was designed and developed. Based on the use of phycocyanin for the biomineralization of manganese ions, smart and multifunctional manganese phycocyanin nanoparticles encapsulating the immune adjuvant levamisole (LMS) with melanoma B16-OVA cell membranes wrapped around its outer layer (Mn-PCNP-LMS@CM) were designed and prepared.

Collagen/chitosan/genipin hydrogel loaded with phycocyanin nanoparticles and ND-336 for diabetic wound healing.

Diabetic wound healing remains a healthcare challenge due to the overexpression of matrix metalloproteinase-9 (MMP-9) and the imbalance between angiogenic factors and vascular inhibitory factors. In this study, we developed a nanocomposite injectable collagen/chitosan hydrogel for the treatment of delayed diabetic wound healing, which can promote cell migration to the wound site (through the addition of phycocyanin) and reduce the expression of MMP-9 (through the use of ND-336) to improve the therapeutic effect of diabetic wound healing. Furthermore, different weight ratios of collagen and chitosan hydrogels were prepared to select the hydrogel with proper mechanical properties.