Induction of Strong Magneto-Optical Effect and High Compatibility with Si of BiFeO Thin Film by Sr and Ti Co-Doping.

The poor magnetic and magneto-optical properties of BiFeO, along with its significant lattice mismatch with silicon, have limited its application in silicon-based integrated magneto-optical devices. In this study, co-doping with Sr and Ti ions effectively transformed the trigonal structure of BiFeO into a cubic phase, thereby reducing the lattice mismatch with silicon to 2.8%.

Dataset for Single Character Detection in Dongba Manuscripts.

The Dongba script, a unique pictographic writing system invented by the ancestors of the Naxi people of China, holds great significance for interpreting the ancient Naxi language, history, and culture. Accurate detection of the Dongba script is crucial for in-depth research into Dongba manuscripts. Through automated Dongba script detection technology, experts can efficiently extract precise text data from many manuscripts, providing essential support for the subsequent translation of Dongba script and constructing a corpus.

Novel β-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway.

A novel series of hybrids from β-carboline and hydroxamic acid were designed and synthesized. Several compounds (5m, 11b-d, and 11h) not only exerted significant antiproliferation activity against four human colorectal cancer (CRC) cell lines but also showed histone deacetylase inhibitory effects in vitro. The most potent compound, 11c, exhibited anticancer potency sevenfold higher than that of SAHA.

Hybrids from Farnesylthiosalicylic Acid and Hydroxamic Acid as Dual Ras-Related Signaling and Histone Deacetylase (HDAC) Inhibitors: Design, Synthesis and Biological Evaluation.

A novel series of hybrids was designed and synthesized by combining key elements from farnesylthiosalicylic acid (FTS) and hydroxamic acid. Several 3,7,11-trimethyldodeca-2,6,10-trien-1-yl) thio)benzamide derivatives, particularly those with branched and linear aliphatic linkers between the hydroxamic zinc binding group (ZBG) and the benzamide core, not only displayed significant antitumor activities against six human cancer cells but also exhibited histone deacetylase (HDAC) inhibitory effects in vitro. Among them, N-(4-(hydroxyamino)-4-oxobutyl)-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6, 10-trien-1-yl)thio)benzamide (8 d) was the most potent, with IC50 values of 4.

Synthesis and biological evaluation of novel farnesylthiosalicylic acid derivatives for cancer treatment.

Novel farnesylthiosalicylic acid (FTS) derivatives were synthesized by coupling with different substituted diamines. Their in vitro growth inhibitory activities against seven human cancer cell lines were evaluated. The results revealed that the synthetic farnesylthiosalicylamides displayed significant antitumor activities compared to the positive control FTS.