The effects of sex and age on movie-watching functional connectivity and movie clip classification.

Functional connectivity (FC) is a key tool for understanding the complex interactions within the human brain, highlighting connections between various regions. This study delves into the multifaceted influences shaping functional magnetic resonance imaging FC patterns during movie watching, focusing on the effects of sex, age, and movie clip. Leveraging the Human Connectome Project dataset, we systematically examine FC patterns elicited during movie watching.

The lifelong nonlinear development of spatial variability of brain signals.

The physiological information carried by brain signals is distinguished by their mean and variability. Research has indicated that both the variability of local signals and the spatial mean of the whole-brain signal (known as the global signal, GS) are sensitive to brain development. This raises the question of whether the spatial variability of the whole-brain signal, referred to as global variability (GV), could potentially serve as a more specific marker of brain development.

SSH3 promotes pancreatic cancer proliferation and migration by activating the notch signaling pathway.

Recent studies have indicated that the dual-specificity phosphatases (DUSP) family may play a role in the advancement of pancreatic cancer. Exploring the role of the DUSP family in pancreatic cancer development and discovering novel therapeutic targets are crucial for pancreatic cancer therapy. A critical subset of 20 genes exhibiting differential expression was identified, with particular emphasis on four key genes: DUSP10, PTP4A2, SSH3, and CDKN3 by multivariate Cox proportional hazards analysis.

Frequency-dependent alterations of global signal topography in patients with major depressive disorder.

Background: Major depressive disorder (MDD) is associated not only with disorders in multiple brain networks but also with frequency-specific brain activities. The abnormality of spatiotemporal networks in patients with MDD remains largely unclear.

Methods: We investigated the alterations of the global spatiotemporal network in MDD patients using a large-sample multicenter resting-state functional magnetic resonance imaging dataset.

Spatiotemporal dedifferentiation of the global brain signal topography along the adult lifespan.

Age-related variations in many regions and/or networks of the human brain have been uncovered using resting-state functional magnetic resonance imaging. However, these findings did not account for the dynamical effect the brain's global activity (global signal [GS]) causes on local characteristics, which is measured by GS topography. To address this gap, we tested GS topography including its correlation with age using a large-scale cross-sectional adult lifespan dataset (n = 492).

Frequency-dependent effective connections between local signals and the global brain signal during resting-state.

Unlabelled: The psychological and physiological meanings of resting-state global brain signal (GS) and GS topography have been well confirmed. However, the causal relationship between GS and local signals was largely unknown. Based on the Human Connectome Project dataset, we investigated the effective GS topography using the Granger causality (GC) method.

The thalamus is the causal hub of intervention in patients with major depressive disorder: Evidence from the Granger causality analysis.

Major depressive disorder (MDD) is the leading mental disorder and afflicts more than 350 million people worldwide. The underlying neural mechanisms of MDD remain unclear, hindering the accurate treatment. Recent brain imaging studies have observed functional abnormalities in multiple brain regions in patients with MDD, identifying core brain regions is the key to locating potential therapeutic targets for MDD.

MJDs family members: Potential prognostic targets and immune-associated biomarkers in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common gastrointestinal malignancies. It is not easy to be diagnosed in the early stage and is prone to relapse, with a very poor prognosis. And immune cell infiltration and tumor microenvironment play important roles in predicting therapeutic response and prognosis of HCC.

The temporal dedifferentiation of global brain signal fluctuations during human brain ageing.

The variation of brain functions as healthy ageing has been discussed widely using resting-state brain imaging. Previous conclusions may be misinterpreted without considering the effects of global signal (GS) on local brain activities. Up to now, the variation of GS with ageing has not been estimated.

Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations.

The global signal (GS), which was once regarded as a nuisance of functional magnetic resonance imaging, has been proven to convey valuable neural information. This raised the following question: what is a GS represented in local brain regions? In order to answer this question, the GS topography was developed to measure the correlation between global and local signals. It was observed that the GS topography has an intrinsic structure characterized by higher GS correlation in sensory cortices and lower GS correlation in higher-order cortices.