In Situ Fabrication of High Ionic and Electronic Conductivity Interlayers Enabling Long-Life Garnet-Based Solid-State Lithium Batteries.

Garnet-type LiLaZrTaO (LLZTO) is a promising solid-state electrolyte (SSE) because of its fast ionic conduction and notable chemical/electrochemical stability toward the lithium (Li) metal. However, poor interface wettability and large interface resistance between LLZTO and Li anode greatly restrict its practical applications. In this work, we develop an in situ chemical conversion strategy to construct a highly conductive LiS@C layer on the surface of LLZTO, enabling improved interfacial wettability between LLZTO and the Li anode.

Identification of novel 3-aryl-1-aminoisoquinolines-based KRAS inhibitors: Rational drug design and expedient construction by CH functionalization/annulation.

Developing a synthetic methodology to expediently construct a specific drug scaffold with the desired biological activity remains challenging. Herein, we describe a work on rational application of a synthetic methodology in the synthesis of KRAS inhibitors. Novel KRAS inhibitors were initially designed with 1-amino-3-aryl isoquinoline scaffold using structure-based drug design strategy.