Preparation and in vitro evaluation of pH and glutathione dual-responsive drug delivery system based on sodium carboxymethyl cellulose.

Stimuli-responsive drug delivery systems based on sodium carboxymethyl cellulose (NaCMC) for drug release encounter inherent challenges. In this research, a novel pH and glutathione (GSH) dual-responsive system, CPT-S-S-NaCMC@ZIF-8/SP-PEG, was constructed. Firstly, the prodrug CPT-S-S-OH was synthesized and combined with NaCMC to form GSH-responsive micelles CPT-S-S-NaCMC, significantly enhancing the drug loading and grafting rates to 63.

Research on the Reasonable Grouting Strength of Rock-Like Samples in Different Strengths.

One of the key points to make grouting reinforcement technology efficient and economical in engineering is to find out the optimal match relationship between different strengthsofrock mass and strength ofgrouting material. It can be called areasonable grouting strength. To explore that, 5 kinds of (compressive strength of cement mortar) were used to make samples to simulate the different rock strengths.

Experimental study on the effect of grouting reinforcement on the shear strength of a fractured rock mass.

To study the strengthening mechanism and effect underlying the reinforcement of a fractured rock mass with grouting, compressive shear tests were conducted with an RMT-150B rock mechanics test system. Prefabricated structural surfaces were strengthened with a new inorganic dual-liquid grouting material at five water-cement ratios (0.6-1.