Publications by authors named "Cheng-Hung Li"
2025 THRS Expert Consensus of Imaging Assessment in Atrial Fibrillation. .
Acta Cardiol Sin
July 2025
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in the elderly population with a high lifetime risk after the age of 45 years, leading to a major impact on the public health from elicited left atrial (LA) thrombogenesis and cardioembolic stroke. Imaging in the AF population plays a crucial role, not only in assessing LA size but also in delineating the underlying cardiac structural and functional features to reach a more specific diagnosis. Contemporary clinical practice guideline recommended anticoagulation therapy based on annual thromboembolic event risk using a validated clinical risk score.
View Article and Find Full Text PDFLong-term outcome of lesion size index-guided high-power ablation with high-density mapping for pulmonary vein isolation in patients with paroxysmal atrial fibrillation.
J Arrhythm
August 2025
Introduction: Data on the long-term outcomes and procedural details of the lesion size index-guided high-power ablation strategy (HP-LSI) are limited.
Methods: Eighty patients were retrospectively assigned to the high-power with time-restricted ablation strategy (fixed at 10 s per lesion), while 67 patients were assigned to the high power LSI-guided strategy (anterior wall LSI at least 5.0, posterior wall LSI 4.
Electrocardiographic Characteristics of Ventricular Arrhythmias Originating From High Right Ventricular Outflow Tract and Pulmonary Artery.
J Cardiovasc Electrophysiol
July 2025
Background: Ventricular arrhythmias (VAs) may originate from the right ventricular outflow tract (RVOT) below the pulmonary sinus cusps (PSCs) or from the pulmonary artery (PA) above the PSCs. However, the electrocardiographic (ECG) characteristics of these VAs are not well defined.
Objective: This study aimed to investigate the ECG characteristics of VAs originating from the high RVOT and PA.
SGLT2i and Cardiovascular Events in Patients With Concomitant Atrial Fibrillation and Diabetes: A TriNetX Cohort Study.
J Clin Endocrinol Metab
August 2025
Aims: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) enhance cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2DM). Whether such effects also occur in T2DM patients with atrial fibrillation (AF) remains unknown. We aimed to investigate SGLT2i use on cardiovascular outcomes in patients with concomitant AF and T2DM.
View Article and Find Full Text PDFAims: Early rhythm control therapy in atrial fibrillation (AF) results in higher freedom from atrial arrhythmia (AA) recurrence and improved cardiovascular outcomes. The optimal timing of cryoballoon ablation (CBA) is unknown.
Methods And Results: We evaluated AA recurrence and procedure-related complications of early vs.
Rhythm Control Better Prevents Stroke than Rate Control in Patients with Concomitant Hypertrophic Cardiomyopathy and Atrial Fibrillation: A Nationwide Population Based Cohort Study with Long-Term Follow-Up.
Acta Cardiol Sin
January 2025
Background: Atrial fibrillation (AF) increases the risks of stroke and mortality. It remains unclear whether rhythm control reduces the risk of stroke in patients with AF concomitant with hypertrophic cardiomyopathy (HCM).
Methods: We identified AF patients with HCM who were ≥ 18 years old in the Taiwan National Health Insurance Database.
Lower contact force predicts right pulmonary vein carina breakthrough after ablation index-guided pulmonary vein isolation using high-power short-duration.
J Cardiovasc Electrophysiol
January 2024
Article Synopsis
- The study investigates the occurrence of Carina breakthrough (CB) at the right pulmonary vein (RPV) after a specific ablation procedure in atrial fibrillation patients.
- Out of 62 patients, 33.87% experienced RPV CB, and those affected had lower contact force (CF) at lesions near the RPV carina compared to those who did not.
- The research found that a CF of less than 10.5 grams is a potential predictor of RPV CB, suggesting that higher CF during ablation could help reduce this complication.
Comparison of Long-Term Clinical Outcomes Between Segmental and Circumferential Pulmonary Vein Isolation in Patients Undergoing Repeat Atrial Fibrillation Ablation.
Circ J
November 2023
Article Synopsis
- This study compares the effectiveness of circumferential pulmonary vein isolation (CPVI) and segmental pulmonary vein isolation (SPVI) in patients undergoing redo ablations for recurrent atrial fibrillation (AF).
- 543 patients who had AF ablation were analyzed, with 141 included in the final assessment; the results showed similar AF-free survival rates for both techniques, but a significant difference in atrial flutter recurrence favoring CPVI.
- The findings suggest that while SPVI and CPVI are comparable for AF recurrence, SPVI has a higher rate of atrial flutter, potentially linked to more residual pulmonary vein gaps over time.
Background: Modifying the autonomic system after catheter ablation may prevent the recurrence of atrial fibrillation (AF). Evaluation of skin sympathetic nerve activity (SKNA) is a noninvasive method for the assessment of sympathetic activity. However, there are few studies on the effects of different energy settings on SKNA.
View Article and Find Full Text PDFFractal complexity alternations in paroxysmal atrial fibrillation patients with and without recurrence after pulmonary vein isolation.
Ann Noninvasive Electrocardiol
September 2023
Background: Pulmonary vein isolation (PVI) is a cornerstone therapy for paroxysmal atrial fibrillation (PAF). The variations in nonlinear heart rate variability (HRV) between patients with and without recurrences remain unclear. We aimed to characterize the nonlinear HRV before and after PVI in patients with and without recurrence.
View Article and Find Full Text PDFBackground: Therapeutic hypothermia (TH) increases the susceptibility to ventricular arrhythmias (VAs) by prolonging action potential duration (APD) and facilitating arrhythmogenic spatially discordant alternans (SDA). Levosimendan, a calcium sensitizer, has been reported to shorten APD by enhancing the adenosine triphosphate (ATP)-sensitive K current.
Objective: The purpose of this study was to test the hypothesis that, during TH, levosimendan shortens the already prolonged APD, attenuates SDA, and prevents VA.
Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy.
J Clin Med
December 2022
(1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT.
View Article and Find Full Text PDFPost-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias.
J Cardiol
May 2023
Article Synopsis
- The study investigates changes in skin sympathetic nerve activity (SKNA) in patients undergoing catheter ablation for idiopathic ventricular arrhythmia (VA).
- Researchers monitored 43 patients' SKNA before and after the ablation procedure to assess neuromodulation effects.
- Results showed that patients whose ablation was successful had lower post-ablation SKNA compared to those with failed procedures, particularly those whose arrhythmias involved the right ventricular outflow tract (RVOT).
As the world's population is aging and there is a shortage of sufficient caring manpower, the development of intelligent care robots is a feasible solution. At present, plenty of care robots have been developed, but humanized care robots that can suitably respond to the individual behaviors of elderly people, such as pose, expression, gaze, and speech are generally lacking. To achieve the interaction, the main objectives of this study are: (1) conducting a literature review and analyzing the status quo on the following four core tasks of image and speech recognition technology: human pose recognition, human facial expression recognition, eye gazing recognition, and Chinese speech recognition; (2) proposing improvement strategies for these tasks based on the results of the literature review.
View Article and Find Full Text PDFPatterns and Characteristics of SKYLINE-Lumipoint Feature in the Catheter Ablation of Atypical Atrial Flutter: Insight from a Novel Lumipoint Module of Rhythmia Mapping System.
J Pers Med
July 2022
Article Synopsis
- Atypical atrial flutter (aAFL) is common after cardiac surgeries or procedures for atrial fibrillation, and this study aimed to improve ablation techniques using a new mapping algorithm.
- Researchers studied 15 patients with 20 cases of aAFL, finding that the ablation sites identified by analyzing global activation histograms (GAH) were highly effective in targeting reentry circuits.
- The use of the Lumipoint algorithm facilitated better identification of slow conduction areas, leading to quicker aAFL termination and improved patient outcomes.
Risks of Ventricular Tachyarrhythmia and Mortality in Patients with Amyloidosis - A Long-Term Cohort Study.
Acta Cardiol Sin
July 2022
Background: The presence of ventricular tachycardia (VT) is associated with higher mortality. The annual incidence of VT after a diagnosis of amyloidosis and the associated cardiovascular (CV) outcomes have not been well assessed in a large cohort.
Methods: A total of 12,139 amyloidosis patients were identified from the Taiwan National Health Insurance Research Database.
Article Synopsis
- Cryoballoon ablation (CBA) is a treatment for atrial fibrillation (AF) that has mostly been studied in Western countries, and this study focuses on its effectiveness in Asian patients.
- The research included 120 AF patients and found that 74.2% were free from AF one year after CBA, highlighting its efficacy and safety.
- Key predictors for AF recurrence within a year were identified as having persistent AF, a left atrial diameter (LAD) of 4.75 cm or more, and previous cardioversion, with no strokes reported among participants post-procedure.
Article Synopsis
- Scientists studied how diabetes and high uric acid levels affect people with kidney problems.
- They found that both conditions make it more likely for patients to die or get worse kidney disease.
- When someone has both diabetes and high uric acid, the risks of dying and getting serious kidney disease are even higher.
Article Synopsis
- A study examined whether rhythm control strategy for treating atrial fibrillation (AF) can lower dementia risk compared to rate control strategy.
- Researchers analyzed data from 3,382 AF patients aged 65 and older, finding that those on rhythm control medications had a reduced incidence of dementia during a nearly 5-year follow-up.
- The results indicated that patients on rhythm control had a significant 25% lower risk of developing dementia, especially among those who were also taking aspirin.
Article Synopsis
- A study investigated the long-term cardiovascular outcomes of patients with typical and atypical atrial flutter (AFL) who underwent catheter ablation compared to those who received medical therapy without ablation.
- The study analyzed 3,784 AFL patients, finding that those who had catheter ablation experienced significantly lower risks of all-cause mortality, cardiovascular-related deaths, heart failure hospitalizations, and stroke.
- The results suggest that catheter ablation for AFL in patients without a history of atrial fibrillation leads to better long-term health outcomes.
Detecting supraventricular tachycardia with smartwatches facilitates the decision for catheter ablation: A case series.
Pacing Clin Electrophysiol
January 2022
Article Synopsis
- Smartwatches are effective for detecting arrhythmias like atrial fibrillation, but there's uncertainty about their ability to identify supraventricular tachycardia (SVT).
- A study reported three cases where patients with infrequent palpitations had their SVTs only recorded by smartwatches, not by hospital ECGs.
- The study suggests that when a smartwatch detects SVT in patients with recurring tachycardia, an electrophysiological study should be done immediately instead of waiting for a standard ECG, potentially leading to quicker treatment.
The impact of height on recurrence after index catheter ablation of paroxysmal atrial fibrillation.
J Interv Card Electrophysiol
September 2022
Article Synopsis
- The study investigates the impact of height on the outcomes of catheter ablation in patients with drug-resistant paroxysmal atrial fibrillation (AF).
- A total of 689 patients were analyzed, with findings showing that shorter patients experienced lower rates of AF recurrence post-ablation, particularly in females over 159 cm tall.
- The results indicate that height affects AF recurrence in women, with taller female patients being at a greater risk of experiencing recurrence after the procedure.
Novel model-based point scoring system for predicting stroke risk in atrial fibrillation patients: Results from a nationwide cohort study with validation.
Int J Cardiol Heart Vasc
June 2021
Article Synopsis
- A new scoring system called the AF-CA-Stroke score has been developed to assess stroke risk for atrial fibrillation patients specifically taking into account their catheter ablation status.
- The scoring system incorporates factors such as age, ablation status, history of stroke, and other health conditions, providing a point-based assessment.
- This model outperformed traditional scoring systems like CHADS/CHADSVASc in predicting long-term stroke risks, demonstrating significant clinical utility in managing atrial fibrillation patients.