Exploring the potential mechanism of Lamiophlomis rotata (Benth.) Kudo in treating acne through network pharmacology and experimental verification.

Ethnopharmacological Relevance: Lamiophlomis rotata (Benth.)Kudo(L. rotata), known in China as Duyiwei (DYW), is a well-known traditional Tibetan medicine.

Discovery of novel genipin derivatives as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is limited in treatment options due to the absence of three receptors, and evidence suggests that TNBC is sensitive to ferroptosis. In this study, a series of genipin derivatives were synthesized through a hybridization strategy that integrated the structures of RSL3 and ML162. Among these derivatives, compound B23 demonstrated remarkable activity against the MDA-MB-231 cell line with an IC value of 40 nM, significantly outperforming genipin, RSL3 and ML162.

Design, synthesis, and biological evaluation of harmine derivatives as topoisomerase I inhibitors for cancer treatment.

A series of β-carboline derivatives were designed and synthesized by introducing the chalcone moiety into the harmine. The synthesized derivatives were evaluated their anti-proliferative activities against six human cancer cell lines (MCF-7, MDA-MB-231, HepG2, HT29, A549, and PC-3) and one normal cell line (L02). Among them, compound G11 exhibited the potent anti-proliferative activity against MCF-7 cell line, with an IC value of 0.

Fluorescence "Off-On" Probe for L-Cysteine Detection Based on Nitrogen Doped Carbon Dots.

Herein, a simple and efficient fluorescence analysis method for L-Cysteine (L-Cys) was established. The method was based on the fluorescent "off-on" mode of nitrogen doped carbon dots (NCDs). The NCDs were prepared via a facile one-step solvothermal method.