Publications by authors named "C Linn Cadieux"

Planet formation models indicate that the formation of giant planets is substantially harder around low-mass stars due to the scaling of protoplanetary disc masses with stellar mass. The discovery of giant planets orbiting such low-mass stars thus imposes strong constraints on giant planet formation processes. Here we report the discovery of a transiting giant planet orbiting a 0.

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Chemical warfare nerve agents (CWNAs) are potent and irreversible inhibitors of acetylcholinesterase (AChE). Oxime reactivators are an important part of the standard treatment for CWNA exposure as they can reactivate inhibited AChE. Evaluating the oxime candidates of interest in biological samples requires analytical detection methods and oxime reactivators as a class of compounds have historically been notoriously difficult to isolate, detect and analyze in an analytical laboratory, and there are currently no sensitive or robust analytical detection methods in the literature.

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Article Synopsis
  • Organophosphoate (OP) chemicals inhibit the enzyme acetylcholinesterase (AChE), making it challenging to study OP poisoning due to animals' natural resistance from serum carboxylesterase.
  • * A new genetically modified mouse strain, KIKO, was created to lack serum carboxylase and to express a human-like AChE protein, providing a better model for OP research.
  • * In the study, KIKO mice showed increased acetylcholine levels after OP exposure, and the presence of a reactive countermeasure in the brain was detected, highlighting the potential of these mice for developing OP antidotes.*
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Study DesignIn-vitro cadaveric biomechanical study.ObjectivesLong posterior spinal fusion is a standard treatment for adult spinal deformity. However, these rigid constructs are known to alter motion and stress to the adjacent non-instrumented vertebrae, increasing the risk of proximal junctional kyphosis (PJK).

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