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Study DesignIn-vitro cadaveric biomechanical study.ObjectivesLong posterior spinal fusion is a standard treatment for adult spinal deformity. However, these rigid constructs are known to alter motion and stress to the adjacent non-instrumented vertebrae, increasing the risk of proximal junctional kyphosis (PJK). This study aimed to biomechanically compare a standard rigid construct vs constructs "topped off" with a semi-rigid construct. By understanding semi-rigid constructs' effect on motion and overall construct stiffness, surgeons and researchers could better optimize fusion constructs to potentially decrease the risk of PJK and the need for revision surgery.MethodsNine human cadaveric spines (T1-T12) underwent non-destructive biomechanical range of motion tests in pure bending or torsion and were instrumented with an all-pedicle-screw (APS) construct from T6-T9. The specimens were sequentially instrumented with semi-rigid constructs at T5: (i) APS plus sublaminar bands; (ii) APS plus supralaminar hooks; (iii) APS plus transverse process hooks; and (iv) APS plus short pedicle screws.ResultsAPS plus transverse process hooks had a range of motion (ie, relative angle) for T4-T5 and T5-T6, as well as an overall mechanical stiffness for T1-T12, that was more favourable, as it reduced motion at adjacent levels without a stark increase in stiffness. Moreover, APS plus transverse process hooks had the most linear change for range of motion across the entire T3-T7 range.ConclusionsPresent findings suggest that APS plus transverse process hooks has a favourable biomechanical effect that may reduce PJK for long spinal fusions compared to the other constructs examined.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571626 | PMC |
http://dx.doi.org/10.1177/21925682241259695 | DOI Listing |
J Vis Exp
August 2025
Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University;
Posterior lumbar screw fixation is the most common surgical method for lumbar disc herniation, but patients often face multiple complications postoperatively. The occurrence of screw track loosening can lead to fusion failure and even life-threatening screw track extrusion. However, there is currently a lack of animal models specifically targeting changes in the screw track following lumbar screw fixation.
View Article and Find Full Text PDFUltrasound Med Biol
September 2025
Department of Ultrasound Imaging, Xiamen Medical College Affiliated Second Hospital, Xiamen, China.
Accurate identification of fetal torso ultrasound planes is essential in pre-natal examinations, as it plays a critical role in the early detection of severe fetal malformations and this process is heavily dependent on the clinical expertise of health care providers. However, the limited number of medical professionals skilled at identification and the complexity of fetal plane screening underscore the need for efficient diagnostic support tools. Clinicians often encounter challenges such as image artifacts and the intricate nature of fetal planes, which require adjustments to image gain and contrast to obtain clearer diagnostic information.
View Article and Find Full Text PDFEur J Orthop Surg Traumatol
September 2025
Human Anatomy Teaching and Research Section, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
Objective: Reveal the changing rule of the positional relationship between the uncinate process of cervical spine and vertebral artery by measuring the relevant parameters between the uncinate process of cervical spine and vertebral artery in different age groups.
Methods: A retrospective study was conducted on 1240 cases of cervical spine imaging data from 2018 to 2021 in the Radiology Department of the Affiliated Hospital of Inner Mongolia Medical University. The distance between the uncinate process superior ridge and vertebral artery and the maximum of pedicle transverse angle, the minimum of pedicle transverse angle, the range of pedicle transverse angle and the pedicle width were measured according to age groups.
Orthop Traumatol Surg Res
September 2025
CHU de Grenoble-Alpes, Université de Grenoble-Alpes, Laboratoire TIMC-IMAG, Unité de Chirurgie Orthopédique et Traumatologique, CNRS UMR 5525, Boulevard de la Chantourne, 38700 La Tronche, France.
Percutaneous pelvic screwing (PPS) enables fixation of traumatic or atraumatic fractures with little or no displacement, or displaced but reduced fractures, and preventive fixation of primary or secondary tumoral lesions. It is a relatively recent technique, and indications are evolving with progress in pre- and intra-operative imaging. Morbidity is lower than with open surgery.
View Article and Find Full Text PDFRedox Biol
September 2025
Department of Cardiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 201620, China. Electronic address:
Pathological cardiac hypertrophy, driven by mitochondrial dysfunction and maladaptive remodeling, remains a therapeutic challenge. This study explores the cardioprotective properties of tectorigenin (Tec) in the context of transverse aortic constriction (TAC)-induced hypertrophy, focusing on mitochondrial homeostasis. In animal models, administration of Tec improved survival rates, reduced cardiac dysfunction, and decreased hypertrophy and fibrosis in TAC mice, while preserving mitochondrial function.
View Article and Find Full Text PDF