Prevention of Neonatal Infections in Newborns Using Kangaroo Care Method: A Systematic Review and Meta-analysis.

This study aimed to investigate the impact of KC on the prevention of neonatal infections. Initial article screening by title and abstract was performed independently by paired reviewers utilizing the RAYYAN tool, with conflicts resolved by a senior researcher. Statistical analysis was conducted using the Review Manager and R version 4.

Detecting vascular normalization in epithelial ovarian cancer.

Epithelial ovarian cancer (EOC) is highly angiogenic, making this tumor attractive, in the last 20 years, for analysis of clinical and biological functions of the VEGF family, relating altered expression with patient's clinical responses. Currently, analyzes and validations have yet to be made to relate vascular normalization with combinations of immune-, chemo- or radiotherapy. We review the main clinical analyses capable of identifying markers of vascular normalization including functional biomarkers (e.

Purification and Preparation of Graphene-like Nanoplates from Natural Graphite of Canindé, CE, Northeast-Brazil.

In this study, flotation tests were conducted on a laboratory scale using a sample of microcrystalline graphite ore from the Canindé region, Ceará, Brazil. The objective was to investigate the grinding time, reagent dosage, and purification process for obtaining graphene-based nanomaterials. Natural graphite has a stacked planar structure and exhibits polymorphism with rhombohedral, hexagonal, and turbostratic geometries, characteristics that directly influence its properties and technological applications.

Molecular survey of tick-borne pathogens in domestic dogs from a rural region within the buffer zone of a conservation unit in the Brazilian Caatinga biome.

Although previous studies have identified Ehrlichia canis, Anaplasma platys, Babesia vogeli, and Hepatozoon canis in dogs in Northeastern Brazil, research on their presence within and around environmental conservation units remains scarce. The present study investigated the presence of tick-borne pathogens in domestic dogs in the rural region of Baraúna, within the buffer zone of the Furna Feia National Park (FFNP), an environmental conservation unit in the Caatinga biome of Rio Grande do Norte, northeastern Brazil. Blood samples from 52 dogs were collected to detect the presence of A.

A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration.

Retrotransposon activation is emerging as a significant factor in neurodegenerative disease pathogenesis. SINE-VNTR-Alu (SVAs) are hominid-specific retrotransposons that create genetic variation through insertion polymorphisms and variable short tandem repeat (STR) lengths. We investigate how the SVA (CCCTCT) STR contributes to the striatal neurodegenerative disorder X-linked dystonia parkinsonism (XDP), where the repeat expansion length within the pathogenic SVA is inversely correlated with age at disease onset.

De novo assembly and annotation of the pantranscriptome of Astyanax lacustris on the liver and pituitary-gonadal axis.

Astyanax lacustris is a model of laboratory native fish species. Reproductive studies of this species have already been performed. Nevertheless, there is a relative shortcoming of gene sequence information available in public databases, which hinder their use in more comprehensive investigations that employ sensitivity molecular biology techniques to assess gene expression profile for biomarker identification.

Strain and doping transfer between suspended and supported bilayer graphene.

Due to their unique dimensionality, the physical properties of two-dimensional materials are deeply impacted by their surroundings, calling for a thorough understanding and control of these effects. We investigated the influence of the substrate and the pressure transmitting medium on bilayer graphene in a unique high-pressure environment where the sample is partially suspended and partially supported. By employing Raman spectroscopy with a sub-micron spatial resolution, we explored the evolution of strain and doping, and demonstrated that they are both similarly induced in the suspended and supported regions of the bilayer graphene within the studied pressure range.

In silico study of a new class of DNA fluorescent probes: docking, molecular dynamics and quantum chemistry calculations.

Context: Natural fluorescence in biochemical structures can result in unsatisfactory outcomes in cell imaging. This drawback can be addressed by using probe molecules that fluoresce via Excited State Intramolecular Proton Transfer (ESIPT), thereby improving resolution and the signal-to-noise ratio. A docking study was conducted to estimate the binding free energy of 132 benzazoles and to determine their binding modes (minor groove (MG) or intercalation (INT)) to DNA, comparing them with the commercial probes 4',6-Diamidino-2-phenylindole dihydrochloride (DAPI) and acridine orange (AO).

Reactivity of Ionic Liquid-Based Phenolate Zwitterions for CO Capture in the Aqueous Phase.

Ideal liquid sorbents, such as phenolate zwitterions, represent a novel and promising technology for CO capture. To enhance their design and reactivity with CO, two types of substituents, electron-donating groups (EDGs) and electron-withdrawing groups (EWGs) were investigated. Using density functional theory (DFT) with a large basis set, their effectiveness as reactivity modulators was assessed through energy decomposition analysis, noncovalent interaction, natural bond orbitals (NBO), evaluation of reaction energy barriers, and pK.

Comprehensive evaluation of volatile compounds and sensory profiles of coffee throughout the roasting process.

Roasting is a crucial process that induces chemical and sensory transformations in coffee beans. Although research indicates that roasting alters the volatile composition of coffee, most studies have collected samples at spaced intervals. Therefore, a continuous and comprehensive evaluation of the commercial roasting process is lacking.

Effect of green propolis crude extract on the modulation of intestinal microbiota and on the productive performance of juvenile Nile tilapia.

The study aimed to investigate the impact of dietary supplementation with green propolis crude extract on juvenile tilapia's growth and intestinal microbiota. The experiment was conducted in raceway tanks with a volume of 19m, comprising two treatments with three replicates each. Fish were assigned to either a control diet or a diet supplemented with 0.

Encephalitozoon intestinalis infection in free-ranging giant anteater (Myrmecophaga tridactyla) and armadillo species (Priodontes maximus, Euphractus sexcinctus, Cabassous squamicaudis).

Microsporidia are emerging, opportunistic fungi that infect a diverse population of vertebrates and invertebrates. Mammals of the superorder Xenarthra can harbor and transmit several pathogens, acting as important sources of infection for spreading various zoonoses. Microsporidia have not yet been described in this group of animals, the aim of this study was to analyze the occurrence of the zoonotic microsporidian Encephalitozoon intestinalis, Encephalitozoon cuniculi and Enterocytozoon bieneusi in the feces of giant anteater (Myrmecophaga tridactyla) and armadillo species (Priodontes maximus, Euphractus sexcinctus, Dasypus novemcinctus, Cabassous squamicaudis) monitored by Wild Animal Conservation Institute (ICAS) in Brazil.

Chiral Oxazoline-Triazole-Benzothiazole Molecular Triads: Photoactive Sensors for Enantioselective Carbohydrate Recognition in Solution.

Understanding the mechanism of drug action in biological systems is facilitated by the interactions between small molecules and target chiral biomolecules. In this context, focusing on the enantiomeric recognition of carbohydrates in solution through steady-state fluorescence emission spectroscopy is noteworthy. To this end, we have developed a third generation of chiral optical sensors for carbohydrates, distinct from all of those previously presented, which interact with carbohydrates to form non-covalent probe-analyte interactions.

Reproduction and Development in Fish: Solving Bottlenecks in Modern Aquaculture.

The aquaculture industry is home to the fastest-growing activity in the agriculture sector worldwide and is one of the leading sectors in global food production [...

Massive Splenomegaly in Felty's Syndrome: A Case Report.

Felty's syndrome (FS) is a rare and complex condition most commonly seen as a complication of longstanding rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly, and neutropenia. Diagnosing FS can be challenging due to its diverse clinical presentations and overlap with other hematologic and autoimmune conditions. We report a 47-year-old male with a history of severe anemia, recurrent blood transfusions, and a chronic leg ulcer.

Bioinformatics and molecular biology tools for diagnosis, prevention, treatment and prognosis of COVID-19.

Since December 2019, a new form of Severe Acute Respiratory Syndrome (SARS) has emerged worldwide, caused by SARS coronavirus 2 (SARS-CoV-2). This disease was called COVID-19 and was declared a pandemic by the World Health Organization in March 2020. Symptoms can vary from a common cold to severe pneumonia, hypoxemia, respiratory distress, and death.

Impact of Chemotherapy Treatment on the Functionality and Quality of Life of Cancer Patients.

Background And Purpose: Cancer is one of the most prevalent diseases in the general population, and is one of the main causes of changes in the population's illness profile. In this study, we assessed changes in the functional status and quality of life of patients in the first months of chemotherapy treatment.

Method: A prospective cohort study was carried out, collecting data from cancer patients seen at an outpatient clinic in the Midwest of Santa Catarina who had breast, lung, colon and rectum, prostate and head and neck cancer.

Can Aluminum Affect Social Behavior and Cortisol Plasma Profile in the Neotropical Freshwater Teleost (Teleostei: Characidae)?

Aluminum (Al) can cause endocrine disruption in aquatic animals, but assessments of animal social behavior in neotropical teleost fish species with importance for Brazilian aquaculture have still not been addressed so far, which can further complete this ecotoxicological knowledge. In order to evaluate the social behavior and plasma cortisol concentration of fish exposed to Al, we performed a 1 h acute exposure with couples in three different experimental groups: control in neutral pH (CTL/n group), acid pH (pH/ac group), and aluminum in acid pH (Al/ac group; 2.0 mg L).

Synthesis, Characterization, and BSA Binding Properties of Carboxylated Merocyanine-Based Fluorophores.

This study describes the synthesis of new carboxylated merocyanine dyes by Knoevenagel condensation between 4-carboxybenzaldehyde and indolium/benzoindolium- and benzothiazolium-based coupling compounds. The condensations were performed in the presence of ammonium acetate, and the products were obtained in good yields after simple purification. These merocyanines exhibit UV-A-to-blue absorption and blue-to-green fluorescence emission, characterized by relatively large Stokes shift values (∼5000 cm).

Molecular Diagnosis of the Main Hemoparasites of Dairy Cows in the State of Ceará.

Background/objectives: Trypanosomiasis and bovine babesiosis correspond to important diseases that cause great economic losses, but there are still no studies evaluating their occurrence in herds of dairy cattle in Ceará. The aim of this study was to perform molecular diagnosis of the main hemoparasites of dairy cows in the microregion of the central hinterland of Ceará.

Methods: For the molecular diagnosis of parasites, genomic material was extracted and polymerase chain reaction directed to the cdCatL-like gene for and SS rRNA of and was performed.

White spots amidst the gold: ultrastructural and histological aspects of the chronic inflammatory response of goldfish with ichthyophthiriasis.

Ichthyophthirius multifiliis, the causative agent of white spot disease, is a ciliated protozoan parasite that infects freshwater fish and induces high mortality. Outbreaks occur both in natural and production sites. The aim of the present study was to describe the lesions caused by chronic infection by I.

From skin sensitizers to wastewater: the unknown photo-deactivation process of low-lying excited states of isothiazolinones. A non-adiabatic dynamics investigation.

Isothiazolinones represent a class of heterocyclic compounds widely used in various applications, including as biocides in cosmetics, detergents, and paints, as well as in industrial wastewater treatment. Indeed, the presence of isothiazolinones in the environment and their associated potential health hazards have raised significant concerns. In this study, a non-adiabatic dynamics investigation was conducted using state-of-the-art methodologies to explore the photochemistry of isothiazolinones.