Publications by authors named "Biswajit Paul"

Background: Understanding the causes and circumstances surrounding drowning events is vital to inform context-specific interventions. Verbal autopsy (VA) instruments have been used to improve the identification of drowning deaths in low-income and middle-income countries. However, the challenges and opportunities of using VA to understand the causes and circumstances surrounding fatal drowning deaths are unknown.

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Red mud (RM) is a solid by-product generated in large quantities from the Bayer process in alumina refinery industries. The high pH and heavy metal content pose significant environmental challenges for its management and disposal. This comprehensive review highlights RM's potential as a source of valuable raw materials, focusing on both economic and environmental implications.

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Soil metagenomics using whole genome shotgun sequencing (WGS) uncovers microbial diversity and functionality in soils. This study aimed to explore microbial diversity and functional adaptation in soils exposed to fly ash near the Kolaghat Thermal Power Plant, West Bengal, India, using whole genome shotgun sequencing. Understanding how microbial communities respond to such contamination is essential for developing effective bioremediation strategies.

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Background: Pulmonary rehabilitation (PR) plays a vital role in managing chronic obstructive pulmonary disease and other chronic respiratory diseases (CRDs). However, implementation of this multidisciplinary approach in resource-poor settings may not be sufficient because of referrers' uncertainty regarding the effectiveness of PR, inconvenient timing, travel issues, patients' lack of motivation, and poor family support. The aim was to test the feasibility of a peer-led, professionally assisted community-based PR programme for CRD patients in a rural, low literacy setting.

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In the current study, extraction of humic acid (HAs) from lignite fines of kutch basin of Gujarat (western India) were reported. The extraction was done by International Humic Substances Society (IHSS) method. Several analytical and spectroscopic techniques were used to characterize of extracted HAs.

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  • A study measured toxic element concentrations (As, Hg, Pb, Zn, Cr, Co, Cu, Cd, and Mn) in soils from reclaimed mine areas, core zones, roadsides, and agricultural plots in Kutch, Gujarat.
  • Roadside soil had the highest levels of mercury, arsenic, lead, and manganese, while core zone soil exhibited the highest levels of zinc, chromium, cobalt, and cadmium.
  • Most of the area showed moderate to very high contamination, with significant ecological risks identified, particularly from cadmium and mercury, highlighting the need for ongoing monitoring and remediation efforts.
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Background: In order for low and middle income countries (LMIC) to transition to Human Papilloma Virus (HPV) test based cervical cancer screening, a greater understanding of how to implement these evidence based interventions (EBI) among vulnerable populations is needed. This paper documents outcomes of an implementation research on HPV screening among women from tribal, rural, urban slum settings in India.

Methods: A mixed-method, pragmatic, quasi-experimental trial design was used.

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  • Chronic respiratory diseases (CRDs) are a significant global health issue, especially in low- and middle-income countries, but can be managed with early diagnosis, proper treatment, and behavior changes.
  • The theory of planned behavior (TPB) has been shown to effectively encourage behavior change, yet most research has focused on wealthier populations.
  • A systematic review of TPB-based interventions in low health literacy settings identified 11 relevant studies, all effective at improving health behaviors, primarily conducted in urban areas.*
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  • Health behavior significantly impacts health outcomes, especially for chronic diseases, and interventions based on psychological theories like the Theory of Planned Behavior (TPB) have shown more success in changing these behaviors.
  • Most research into TPB has focused on developed countries, prompting a need for evidence on its effectiveness in low- and middle-income countries where resources and health literacy may be limited.
  • The methodology for studying this will follow PRISMA-P guidelines, using a structured approach to analyze data from relevant studies, assess bias, and measure the impact of TPB-based interventions on behavior change.
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The presence of arsenic in the groundwater of the densely-populated Bengal Basin evolved as a mass-poisoning agent and is a reason for the misery of millions of people living here. High-level arsenic was detected in the shallow aquifer-tube wells of the basin in the late-20th century. The redox conditions and the biogeochemical activities in the shallow aquifers support the existence of arsenic in its most toxic +3 state.

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Background: Our previous scoping review revealed limitations and inconsistencies in population surveys of chronic respiratory disease. Informed by this review, we piloted a cross-sectional survey of adults in four South/South-East Asian low-and middle-income countries (LMICs) to assess survey feasibility and identify variables that predicted asthma or chronic obstructive pulmonary disease (COPD).

Methods: We administered relevant translations of the BOLD-1 questionnaire with additional questions from ECRHS-II, performed spirometry and arranged specialist clinical review for a sub-group to confirm the diagnosis.

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Background: Chronic respiratory diseases (CRDs) are major causes of mortality and morbidity worldwide with a substantial burden of the disease being borne by the low and middle income countries (LMICs). Interventions to change health behaviour which aim to improve the quality of life and reduce disease burden due to CRD require knowledge of the problem and factors influencing such behaviour. Our study sought to appreciate the lived experiences of people with CRD, their understanding of the disease and its risk factors, and usual practice of health behaviour in a rural low-literate community in southern India.

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In order to fulfil the growing need to replace fossil fuels, investigations exploring the production of biodiesel from agricultural biomass have gained attention. In this study, biodiesels were produced from Madhuca longifolia and Jatropha curcas by means of pre-treatment followed by a two-step acid-base homogeneous catalyst method. These biodiesels were blended with diesel at different percentages.

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  • * This study seeks to create a model to identify optimal water use sites and develop a management plan for a heavily populated and polluted city, focusing on water quality's impacts on human health and the economy.
  • * Using tools like GIS and the analytical hierarchy process (AHP), the study analyzes water quality metrics and creates suitability maps to guide city planners on safe water management for various uses, including drinking and irrigation.
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Purpose: To develop a consensus statement for left atrial appendage occlusion (LAAO) in Asian-Pacific patients with non-valvular atrial fibrillation (NVAF) at risk of ischemic stroke. The need for such a region-specific consensus was indicated by the relative paucity of clinical evidence for LAAO and oral anticoagulation therapy obtained in Asian-Pacific populations and the specific stroke and bleeding characteristics of this population.

Methods: Consensus was developed by discussion and evaluation of available evidence and expert opinions during a 2-day meeting attended by clinical experts from the Asian-Pacific regions.

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In this study, the performance of zirconia-multiwalled carbon-nanotube nanoheterostructure in adsorbing the highly toxic water-contaminant As(III) from water has been probed from the perspective of physical chemistry and chemical physics. The adsorbent found extremely efficient in adsorbing As(III) from potable water. Moreover, its ability to oxidize As(III) to As(V) in the aqueous solution has been evinced by the XPS studies.

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  • Dependency on groundwater has surged due to industrial and urban growth, making it crucial to assess its quality and its effects on health and the environment.
  • This study developed a methodology to evaluate groundwater quality in an industrial area, revealing that 50% of pre-monsoon and 65% of post-monsoon locations had very poor quality water, deemed unsafe for drinking.
  • Analysis indicated that while groundwater is unsuitable for drinking and industrial use due to high corrosivity, it can be used for irrigation, highlighting the need for effective communication of these findings to stakeholders for better water management.
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Background: Rates of cervical and oral cancer in India are unacceptably high. Survival from these cancers is poor, largely due to late presentation and a lack of early diagnosis and screening programmes. Mobile Health ('mHealth') shows promise as a means of supporting screening activity, particularly in rural and remote communities where the required information infrastructure is lacking.

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  • Targeted gene therapy using homology-driven repair (HDR) offers more precise control over gene integration compared to traditional methods, but its low efficiency poses challenges for clinical use.
  • In this study, researchers successfully used HDR to insert a mutant dihydrofolate reductase (mDHFR) gene into the CCR5 gene of human CD4 T cells, achieving up to 40% gene insertion efficiency.
  • The use of methotrexate (MTX) enhanced the selection of modified cells by over five times, suggesting that this method could improve therapies for HIV and cancer by increasing the number of gene-edited T cells.
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A multi-purpose Water Quality Index (WQI) was developed to assess the suitability of surface water for drinking, fish-culture, as well as irrigation in Durgapur industrial city, India. WQI was calculated for 48 sampling locations, where 2.08%, 4.

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  • A 32-base pair deletion in the CCR5 gene has been shown to protect against HIV infection in human CD4 T cells.
  • Researchers developed a megaTAL nuclease that successfully disrupted CCR5 in human T cells, achieving up to 80% modification.
  • Gene-modified CD4 T cells not only resisted HIV infection but also expanded effectively in immunodeficient mice, suggesting potential for immune system reconstitution in patients.
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Dobutamine stress echocardiography (DSE) has come a long way as establishing itself as a feasible, safe, effective, relatively cheaper non-invasive technique to detect population suffering from coronary artery disease (CAD) and following up patients post revascuralization. Besides these DSE is commonly used to diagnose low gradient, low flow true severe aortic stenosis (AS); differentiating it from pseudo- AS and to follow up patients with dilated cardiomyopathy (DCMP). Various non-invasive techniques have different sensitivity and specificity to accurately judge a viable myocardium and to accurately detect the improvement in regional wall motion abnormality (RWMA) post-revascularization, leading to an overall increase in left ventricular ejection fraction (LVEF).

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