Publications by authors named "Binod Kumar"

This paper presents a field-programmable gate array (FPGA) based medical image processing framework using a hardware-software co-design approach for biomedical tasks such as Malaria and Pneumonia detection. The design is implemented on the AMD-Xilinx UltraScale+ MPSoC (ZCU104) FPGA, focusing on optimizing data movement between the Processing System (PS) and Programmable Logic (PL) through a customized high-level synthesis (HLS) process. Depth-wise convolution is employed to reduce computational complexity, while layer fusion is applied to optimize layer-wise execution, and custom cache is integrated to improve memory access efficiency.

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Chondroid syringoma (CS) is a rare benign skin adnexal neoplasm. Its incidence is very low among all primary skin tumors. Diagnosing it clinically can be difficult as it closely resembles other benign salivary or adnexal neoplasms.

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Purpose: Bovine theileriosis, caused by Theileria annulata, presents a significant economic challenge to India's livestock industry. This study investigates the molecular epidemiology of T. annulata in bovine populations from Haryana, India, focusing on the genetic diversity of the Tams1 gene (785 bp).

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Background: Acute spinal cord injury (ASCI) leads to severe neurological deficits with limited prognostic biomarkers. However, S100-beta (S100B), a calcium-binding protein, emerges as a beacon of hope, showing potential as a serological marker of ASCI severity and recovery, inspiring further research and exploration in this field.

Methods: This prospective case-control study included 26 patients with ASCI and 26 age- and sex-matched healthy controls.

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Cutaneous squamous cell carcinoma (cSCC) is a non-melanoma (keratinocyte) skin cancer. cSCC can occur as primary cSCC, second primary cancer (SPC), or metastasis. Histopathology and genetic or molecular studies are used to differentiate SPC from metastasis.

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We report a 37-year-old male patient who had nonbilious vomiting, no passage of flatus, and recurring abdominal pain. This patient had de novo intestinal myeloid sarcoma (MS), a rare and chameleonic presentation of acute leukemia of myeloid origin. The initial diagnostic evaluation suggested Koch's abdomen, and surgical excision of the bowel was performed with a clinical suspicion of Koch's or lymphoma.

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Introduction: Globally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner.

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Thrombocytopenia is common in the critical phase of dengue due to decreased production from the bone marrow and increased peripheral destruction of platelets. Platelet count improves with resolution of the disease. However, further evaluation is required if thrombocytopenia persists for a longer period following dengue infection.

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Background: Technosoils in Inowrocław, central Poland, are impacted by human activities and exhibit high salinity (ECe up to 70 dS/m) due to a soda lime repository. These saline environments pose challenges to plant growth and soil health. However, they also offer an opportunity for the evolution of microorganisms adapted to such conditions, including plant growth-promoting rhizospheric (PGPR) bacteria.

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Haemoparasitic diseases constitute a significant constraint to economic livestock farming. Diagnostic techniques that are inexpensive, rapid, reliable, and precise are crucial for the management of diseases. In this context, PCR assays are very valuable yet expensive since the samples must be processed before being included in the PCR reaction.

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Influenza viruses are known to cause severe respiratory infections in humans, often associated with significant morbidity and mortality rates. Virus replication relies on various host factors and pathways, which also determine the virus's infectious potential. Nonetheless, achieving a comprehensive understanding of how the virus interacts with host cellular components is essential for developing effective therapeutic strategies.

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Article Synopsis
  • - The text discusses the significant threat that genetic diversity in ticks poses to livestock health and agricultural economies globally, highlighting their adaptability to various environments and hosts.
  • - It reviews three key genetic markers—COX1 gene, ribosomal genes, and microsatellites—used to study tick genetic diversity, emphasizing the strengths and limitations of each marker in species differentiation and population studies.
  • - The implications of genetic diversity for vaccine development, particularly the Bm86 vaccine, and the understanding of synthetic pyrethroid resistance in ticks are also addressed, underscoring the need for tailored genetic approaches in tick management strategies.
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  • Biocontainment regulations require research on Nipah virus (NiV) to be carried out in BSL-4 labs, hindering studies on how the virus enters host cells and causes disease.
  • The study developed HiBiT-tagged NiV virus-like particles (VLPs) that can be safely handled in BSL-2 labs, by co-expressing viral proteins in HEK293T cells, while maintaining similarities to the native virus.
  • The HiBiT tag allows for rapid detection of viral interactions and effectiveness of neutralizing antibodies, providing a new, safer method for studying NiV assembly, binding, and entry, as well as for antibody neutralization assays.
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Equine piroplasmosis caused by Theileria equi is a febrile, tick-borne disease of equids. However, there is limited literature about the genotyping of T. equi in India.

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Drugs and chemotherapeutics have helped to manage devastating impacts of infectious diseases since the concept of 'magic bullet'. The World Health Organization estimates about 650,000 deaths due to respiratory diseases linked to seasonal influenza each year. Pandemic influenza, on the other hand, is the most feared health disaster and probably would have greater and immediate impact on humanity than climate change.

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Introduction Subacromial impingement syndrome (SIS) is a common shoulder disorder characterized by pain and limited range of motion in the shoulder joint. It is frequently attributed to the compression or impingement of the rotator cuff tendons and bursa between the humeral head and the acromion process of the scapula during arm elevation. Subacromial impingement syndrome may arise as a result of the morphology of the acromion process, a bony protrusion at the top of the scapula that is important in the biomechanics of the shoulder joint.

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Since 2006, highly pathogenic avian influenza (HPAI) subtypes H5Nx have adversely affected poultry production in Nigeria. Successive waves of infections in the last two decades have raised concerns about the ability to contain infections by biosecurity alone, and evidence of recurrent outbreaks suggests a need for adoption of additional control measures such as vaccination. Although vaccination can be used to control virus spread and reduce the morbidity and mortality caused by HPAI, no country using vaccination alone as a control measure against HPAI has been able to eliminate or prevent re-infection.

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The importance of the microbiome in the functioning of degraded lands in industrialised zones is significant. However, little is known about how environmental parameters affect microbial abundance, structure, diversity, and especially specific guilds involved in the nitrogen cycle in saline soils influenced by the soda industry. To address this knowledge gap, our research focused on assessing the microbiota in relation to soil properties and plant species composition across two transects representing different types of land use: saline wasteland and arable fields.

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The emergence and re-emergence of viral diseases, which cause significant global mortality and morbidity, are the major concerns of this decade. Of these, current research is focused majorly on the etiological agent of the COVID-19 pandemic, SARS-CoV-2. Understanding the host response and metabolic changes during viral infection may provide better therapeutic targets for the proper management of pathophysiological conditions associated with SARS-CoV-2 infection.

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The success of assisted reproduction relies on functional competence of frozen-thawed semen. Heat stress affects protein folding leading to aggregation of mis-folded proteins. Hence, a total of 384 (32 ejaculates/bull/season) ejaculates from six matured Gir bulls were used to evaluate physico-morphological parameters, the expression of HSPs (70 and 90) and fertility of frozen-thawed semen.

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  • The study focuses on creating a multi-target immunization protocol to effectively manage tick infestations in cattle, addressing the challenge of acaricide resistance.
  • Researchers evaluated the effectiveness of proteins BM86, subolesin (SUB), and tropomyosin (TPM) for cross-protective potential against various tick species, finding high sequence identity among Indian tick isolates.
  • After immunizing cattle with recombinant proteins and measuring antibody responses, the multi-antigen approach showed significant vaccine efficacy of over 86% against different life stages of ticks, supporting the development of a new vaccine strategy.
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The present study was aimed at the identification, molecular characterization, and risk factor assessment of infection among sheep of Haryana province, north India. A total of 402 blood samples were collected from three different climatic zones of Haryana from March 2020 to September 2021. Light microscopy of blood smears revealed spp.

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  • The median nerve typically forms from the fusion of two roots (lateral and medial) near the axillary artery, but variations exist such as additional roots and unusual connections with nearby nerves.
  • A study conducted on 84 cadaveric upper limbs at the Indira Gandhi Institute of Medical Sciences found variations in nerve formation, including instances where three or even four roots contributed to the median nerve.
  • In males, three roots were present in 25% of cases, while in females it was 21.42%, leading to insights on the anatomical diversity in the North Indian population.
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Synopsis of recent research by authors named "Binod Kumar"

  • - Binod Kumar's recent research primarily focuses on the development of innovative diagnostic and therapeutic approaches for managing viral diseases and livestock health, particularly highlighting antiviral options for emerging viral threats and genetic diversity among pathogens.
  • - His studies investigate the molecular mechanisms of viral interactions with host cells, including the Influenza virus and Nipah virus, offering insights into viral replication, immune responses, and potential avenues for therapeutic interventions.
  • - Kumar also explores agricultural challenges, specifically addressing the impact of salinity on wheat through halotolerant bacteria and proposing vaccination strategies to control highly pathogenic avian influenza in poultry production, reflecting his interdisciplinary approach to health and agricultural issues.