The Interrelationship Between Andropause Symptoms, Testosterone Levels, and Lower Urinary Tract Symptoms in Men With Benign Prostatic Hyperplasia (BPH): A Cross-Sectional Study.

Introduction This study aimed to assess the prevalence of andropause symptoms and testosterone levels in male patients with symptomatic benign prostatic hyperplasia (BPH), as well as to explore the relationship between these factors. Methods A total of 183 male patients aged 50 years and older with diagnosed lower urinary tract symptoms (LUTS) due to BPH were included. Andropause symptoms were evaluated using the Male Andropause Symptoms Self-Assessment Questionnaire (MASSQ), while testosterone levels were measured using a chemiluminescent immunoassay.

Reduced Expression of Oestrogen Receptors Alpha and Beta in the Prepuce and Urethral Plate of Hypospadias Patients: A Clinical Study.

Introduction: The human skin is an important oestrogen-responsive organ containing the oestrogen receptors ERα and ERβ. Penile foreskin may have similar properties; therefore, typifying the expression and cellular location of oestrogen receptors ERα and ERβ in hypospadiac and normal foreskin can expand our knowledge of the aetiology of hypospadias.

Materials And Methods: We prospectively analysed foreskin and longitudinally excised tissue of the urethral plate of 52 male patients undergoing hypospadias repair.

Lipopeptide: Exploration for enhanced anticandidal therapeutic spectrum.

Growing numbers of human fungal contagions pose a significant threat to the health of society, which is largely brought on by an increase in the number of immunocompromised patients. Pathogenic fungi are usually ignored in discussions of human disease, though they create a big problem after infection. Immunocompromised patients have a high fatality rate due to severe invasive infections from a common polymorphic pathogenic fungus, Candida albicans.

Association Between Erectile Dysfunction and Lower Urinary Tract Symptoms in a North Indian Tertiary Care Hospital.

Introduction This study aimed to investigate the relationship between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in a North Indian population, as well as to assess the influence of age, serum prostate-specific antigen (PSA), and testosterone levels on this association. Materials and methods A cross-sectional study was conducted at King George's Medical University, Lucknow, India, involving 183 men aged ≥50 years presenting with LUTS or benign prostatic hyperplasia (BPH). The severity of ED was assessed using the International Index of Erectile Function-15 (IIEF-15), while LUTS severity was measured using the International Prostate Symptom Score (IPSS).

Unraveling the potential of in sustainable bioplastic production, carbon sequestration, and wastewater treatment using integrated approaches.

With rising concerns over plastic pollution and climate change, microalgae-based bioplastics offer a promising alternative to petroleum-derived plastics. This study explores the dual role of in bioplastic synthesis and environmental remediation through its cultivation in a wastewater-fed bioreactor. By leveraging wastewater as a nutrient source, achieved a biomass yield of 3.

Bis(Dipyrrinate) Based Bis(Germylenes): Synthesis, Reactivity, and UV-Vis Spectroscopic Analysis.

The first examples of air and water stable bis(germylenes) 5-9 and bis(germacarbonyl) compounds 10-12 are reported. Bis(germylene monochloride) 5 is isolated by starting from bis(dipyrromethene) 4, which in turn has been synthesized by oxidizing bis(dipyrromethane) 3 using DDQ. Terephthaldehyde 1 and mesityl pyrrole 2 were the precursors for compound 3.

Current Landscape and Future Directions for Mental Health Conversational Agents for Youth: Scoping Review.

Background: Conversational agents (CAs; chatbots) are systems with the ability to interact with users using natural human dialogue. They are increasingly used to support interactive knowledge discovery of sensitive topics such as mental health topics. While much of the research on CAs for mental health has focused on adult populations, the insights from such research may not apply to CAs for youth.

Role of Gene Xpert MTB/RIF assay for detecting tuberculous spondylitis in specimens obtained by CT-guided aspiration/biopsy and spectrum of imaging findings in spinal tuberculosis.

Objective: To evaluate the utility of the GeneXpert MTB/RIF assay for the diagnosis of tuberculous spondylitis in samples obtained by CT-guided aspiration/biopsy. The effect of anti-tubercular treatment, specimen type, and imaging findings on laboratory results was also assessed along with a comparison of imaging findings in tubercular versus non-tubercular cases.

Methods: This prospective observational study, planned for CT-guided aspiration/ biopsy, included 70 adults with suspected tuberculous spondylitis.

Randomized comparison of precut papillotomy versus an endoscopic ultrasound-guided rendezvous procedure for difficult biliary access in malignant distal biliary obstruction.

Difficult biliary cannulation (DBC) is a marker for prolonged procedure time and a higher rate of adverse events (AEs) during endoscopic retrograde cholangiopancreatography (ERCP). We previously showed that endoscopic ultrasound-assisted rendezvous (EUS-RV) procedures had a higher single-session success rate than precut papillotomy (PCP) in cases of DBC. The present randomized study aimed to compare the technical success and AE rates of the two approachesThis was an open-label randomized controlled trial in a tertiary care setting.

Language disparities in pandemic information: Autocomplete analysis of COVID-19 searches in New York.

To audit and compare search autocomplete results in Spanish and English during the early COVID-19 pandemic in the New York metropolitan area. The pandemic led to significant online search activity about the disease, its spread, and remedies. As gatekeepers, search engines like Google can influence public opinion.

Enhancing Efficiency, Stability, and Cycle Life of Lithium Metal Electrodeposition in Dry Solid-State Polymer Electrolytes.

Dry solid polymer electrolytes (SPEs), particularly those based on poly(ethylene oxide) (PEO), hold significant potential for advancing solid-state Li-metal battery (LMB) technology. Despite extensive research over the years, a comprehensive evaluation of Coulombic efficiency (CE), deposit stability, and cycle life for reversible Li metal electrodeposition in SPE-based cells is still lacking. In this study, we systematically assess the effect of cycling conditions on the CE of Li|SPE|Cu half cells and provide a thorough examination of different electrolyte chemistries, highlighting and explaining their performance across various parameters.

Ensuring Accuracy and Equity in Vaccination Information From ChatGPT and CDC: Mixed-Methods Cross-Language Evaluation.

Background: In the digital age, large language models (LLMs) like ChatGPT have emerged as important sources of health care information. Their interactive capabilities offer promise for enhancing health access, particularly for groups facing traditional barriers such as insurance and language constraints. Despite their growing public health use, with millions of medical queries processed weekly, the quality of LLM-provided information remains inconsistent.

Low-valent Main-group Catalysis under Ambient Conditions using a Germylene Cation.

Catalysis using low-valent main-group compounds is usually done under inert conditions; no example of such catalysis has been doable entirely in ambient conditions until now. This aspect is addressed in this work through an air- and water-stable germylene cation [DPMGe][(OH)B(CF)] (2) (DPM=dipyrromethene); it efficiently catalyzes aldehyde and ketone hydrosilylations under ambient conditions. Detailed theoretical studies reveal that compound 2's stability is bolstered by the interaction between the anion and germanium's frontier orbitals.

KRASFormer: a fully vision transformer-based framework for predictinggene mutations in histopathological images of colorectal cancer.

Detecting the Kirsten Rat Sarcoma Virus () gene mutation is significant for colorectal cancer (CRC) patients. Thegene encodes a protein involved in the epidermal growth factor receptor (EGFR) signaling pathway, and mutations in this gene can negatively impact the use of monoclonal antibodies in anti-EGFR therapy and affect treatment decisions. Currently, commonly used methods like next-generation sequencing (NGS) identifymutations but are expensive, time-consuming, and may not be suitable for every cancer patient sample.

ChatGPT and Vaccine Hesitancy: A Comparison of English, Spanish, and French Responses Using a Validated Scale.

ChatGPT is a popular information system (over 1 billion visits in August 2023) that can generate natural language responses to user queries. It is important to study the quality and equity of its responses on health-related topics, such as vaccination, as they may influence public health decision-making. We use the Vaccine Hesitancy Scale (VHS) proposed by Shapiro et al.

Preoperative Super-Selective Embolization versus "On-Clamp" Laparoscopic Partial Nephrectomy for T1 Renal Tumors- A Prospective Randomized Study.

To analyze and compare the intraoperative and post-operative outcomes of "on-clamp" laparoscopic partial nephrectomy (LPN) with "preoperative super-selective angioembolization" before LPN. This randomized clinical study was conducted at Gauhati Medical College Hospital, Guwahati, India, between November 2021 and November 2023. Adult patients of either gender diagnosed with T1 renal tumors were included in the study.

ATI Stabilized Germylene Cation as a Cyanosilylation Catalyst for Aldehydes and Ketones.

The aminotroponiminate (ATI) ligand stabilized germylene cation [(i-Bu)ATIGe][B(CF)] (2) is found to be an efficient low-valent main-group catalyst for the cyanosilylation of aldehydes and ketones (ATI=aminotroponiminate). It was synthesized by reacting [(i-Bu)ATIGeCl] (1) with Na[B(CF)]. The catalytic cyanosilylation of diverse aliphatic and aromatic carbonyl compounds (aldehydes and ketones) using 0.

Endoscopic ultrasound-guided gastrointestinal anastomosis: Are we there yet?

Endoscopic ultrasound (EUS) is increasingly used as a therapeutic approach for gastrointestinal diseases, especially with the advent of lumen-apposing metal stents (LAMS). This has led to a rise in of EUS-guided gastrointestinal anastomosis procedures. Due to the reliability of intestinal conduits with LAMS, indications for EUS-guided gastrointestinal anastomosis are becoming more common and trend to potentially be standard care for gastric outlet obstruction, afferent loop syndrome, and EUS-directed transgastric interventions such as EUS-directed endoscopic retrograde cholangiopancreatography.

Limbal stem cell deficiency: Demography, aetiology, and clinical presentation in Eastern India.

Aims: To determine demographic details, clinical profile, and underlying causes of limbal stem cell deficiency.

Settings And Design: Descriptive cross-sectional study.

Methods And Material: Patients visiting tertiary referral hospitals between January 2019 and December 2022 who satisfy the criteria for labeling limbal stem cell deficiency (LSCD) were enrolled.

Immunophenotypic characterization of leukemic stem cells in acute myeloid leukemia using single tube 10-colour panel by multiparametric flow cytometry: Deciphering the spectrum, complexity and immunophenotypic heterogeneity.

Introduction: Despite extensive research, comprehensive characterization of leukaemic stem cells (LSC) and information on their immunophenotypic differences from normal haematopoietic stem cells (HSC) is lacking. Herein, we attempted to unravel the immunophenotypic (IPT) characteristics and heterogeneity of LSC using multiparametric flow cytometry (MFC) and single-cell sequencing.

Materials And Methods: Bone marrow aspirate samples from patients with acute myeloid leukaemia (AML) were evaluated using MFC at diagnostic and post induction time points using a single tube-10-colour-panel containing LSC-associated antibodies CD123, CD45RA, CD44, CD33 and COMPOSITE (CLL-1, TIM-3, CD25, CD11b, CD22, CD7, CD56) with backbone markers that is, CD45, CD34, CD38, CD117, sCD3.

Chemical-Vapor-Deposition-Synthesized Two-Dimensional Non-Stoichiometric Copper Selenide (β-CuSe) for Ultra-Fast Tetracycline Hydrochloride Degradation under Solar Light.

The high concentration of antibiotics in aquatic environments is a serious environmental issue. In response, researchers have explored photocatalytic degradation as a potential solution. Through chemical vapor deposition (CVD), we synthesized copper selenide (β-CuSe) and found it an effective catalyst for degrading tetracycline hydrochloride (TC-HCl).

- Improving T-cell response quantification with holistic artificial intelligence based prediction in immunohistochemistry images.

The immune response associated with oncogenesis and potential oncological ther- apeutic interventions has dominated the field of cancer research over the last decade. T-cell lymphocytes in the tumor microenvironment are a crucial aspect of cancer's adaptive immunity, and the quantification of T-cells in specific can- cer types has been suggested as a potential diagnostic aid. However, this is cur- rently not part of routine diagnostics.

Recurrent tracheo-esophageal fistula- management challenges: Case report and review of current literature.

Recurrent tracheoesophageal fistula is a rare complication of esophageal atresia surgery with an incidence of 3-15%. The presentation is subtle and is often missed, presenting as choking episodes during feed and recurrent chest infections. It is both a diagnostic and management challenge and requires a dedicated multidisciplinary pediatric surgical setup with adequate infrastructure for optimal management.