Quality of life in children with epilepsy: Effect of socio-demographic factors and Parental awareness of seizure action plan in Eastern India.

Background: Epilepsy is a chronic neurological disorder that disrupts daily life and negatively impacts quality of life (QOL). While most medical approaches focus on seizure control, there is limited attention to the QOL of children with epilepsy (CWE) in eastern India. This study aimed to assess QOL among CWE and examine the influence of sociodemographic factors, seizure characteristics, and parental awareness of a seizure action plan (SAP).

Unveiling Hyperinflammation in Severe Dengue With Coinfection Among Children: A Case Series.

Dengue illness follows three phases: febrile, critical, and convalescent. Coinfection and hyperinflammatory response are common causes of the persistence of fever beyond the febrile phase of dengue. However, finding both these causes together in severe dengue cases is rarely reported in the literature.

Severe and Persistent Thrombocytopenia in an Adolescent Girl Following Dengue Infection Manifesting As Pulmonary Hemorrhage.

Thrombocytopenia is common in the critical phase of dengue due to decreased production from the bone marrow and increased peripheral destruction of platelets. Platelet count improves with resolution of the disease. However, further evaluation is required if thrombocytopenia persists for a longer period following dengue infection.

An Interesting Case of Refractory Kawasaki Disease With Co-infection.

Kawasaki disease (KD), formerly called mucocutaneous lymph node syndrome, is one of the common vasculitides of childhood. KD most commonly occurs in children over six months up to five years of age, although it can occur in young infants, older children, and adults. Early diagnosis is critical to achieving optimal treatment.

Therapeutic targeting approach on epithelial-mesenchymal plasticity to combat cancer metastasis.

Epithelial-mesenchymal plasticity (EMP) is a process in which epithelial cells lose their characteristics and acquire mesenchymal properties, leading to increased motility and invasiveness, which are key factors in cancer metastasis. Targeting EMP has emerged as a promising therapeutic approach to combat cancer metastasis. Various strategies have been developed to target EMP, including inhibition of key signaling pathways, such as TGF-β, Wnt/β-catenin, and Notch, that regulate EMP, as well as targeting specific transcription factors, such as Snail, Slug, and Twist, that promote EMP.

Persistence of Antibodies Against Spike Glycoprotein of SARS-CoV-2 in Healthcare Workers Post Double Dose of BBV-152 and AZD1222 Vaccines.

We investigated the persistence of the vaccine-induced immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Odisha who received a complete dose of either Covaxin or Covishield vaccine. This 24-week longitudinal cohort study was conducted from January to July 2021 with participants from 6 healthcare and research facilities of Odisha to understand the dynamicity of the vaccine-induced IgG antibodies against SARS-CoV-2 after the complete dose of vaccines. Serum samples were collected from 614 participants during each follow-up and were tested in two chemiluminescent microparticle immunoassay (CLIA)-based platforms to detect SARS-CoV-2 antibodies both qualitatively and quantitatively.