Outcomes of abdominal wall reconstruction in complex ventral hernia patients: a single institution based prospective study.

Introduction: Complex ventral hernias, especially in patients with prior surgeries, large defects, or comorbidities, are associated with high rates of recurrence and complications such as infection, pain, and loss of abdominal domain. This study aims to contribute to developing standardised management strategies.

Methods: A prospective study was conducted at BP Koirala Institute of Health Sciences over two years, involving 38 patients undergoing abdominal wall reconstruction for complex ventral hernias.

A review of herbal therapeutics for the prevention and management of poxvirus infections.

Poxvirus continues to pose public health concerns due to sporadic outbreaks, zoonotic transmission, and limited treatment options. The accessibility of vaccines and antivirals does not resolve the problems of drug resistance, adverse effects, and limited accessibility, which underscores the necessity to find different therapeutic approaches. This review aims to explore the potential of herbal therapy as an effective and accessible treatment for human poxvirus infections.

Minimally invasive surgery for acute groin hernias: A systematic review and meta-analysis.

Background: An open approach is widely used for the surgical treatment of acute groin hernia, however, in recent decades multiple studies have explored the safety and benefits of minimally invasive surgery (MIS) for acute groin hernia.

Methods: A systematic literature search was performed on the electronic databases and meta-analysis was performed using the RevMan 5.4.

Endo-loop or interrupted suture closure of gallbladder remnant during laparoscopic subtotal cholecystectomy- a retrospective analysis of our experience at a high-volume centre of Eastern Nepal.

Introduction: Subtotal laparoscopic cholecystectomy (LSC) is a rescue procedure in difficult case, retaining all advantages of minimally invasive surgery. The most reputed definition of subtotal cholecystectomy is the removal of 3/4th of gallbladder with closure of the infundibulum. The closure of the infundibulum can be with either intracorporeal interrupted suture or pre-knotted endo-loop.

Catering the Need of Drug Manufacturing Standard in India: An Update to Indian Pharmacopoeia.

India is currently among the top 10 pharmaceutical markets by value and is the third largest by volume in 2024; it manufactures more than 65,000 generic drugs across 60 therapeutic segments. Holding a 20% market share of generics, the industry is a key supplier to Africa and the USA and other markets. Following the Drugs and Cosmetics Act of 1940, for the manufacture of drugs in India, there is always legal supervision on the quality of the products being manufactured in the country.

Peritoneal flap hernioplasty for large ventral hernias: a systematic review and meta-analysis : PFH for large ventral hernia.

Background: Primary closure of large ventral hernia is difficult and is usually complicated by postoperative mesh bulge, migration, and higher recurrence. Techniques like component separation and bridging mesh, transversus abdominus release, da Silva triple-layer repair, and peritoneal flap hernioplasty (PFH) are common treatment options.

Objective: To evaluate the early postoperative and long-term outcomes of PFH for large ventral hernias.

A comparative study on effects of defect closure versus non-closure in laparoscopic totally extraperitoneal repair of direct inguinal hernia.

Introduction: Totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) repair are the principal techniques in laparoscopic hernia repair. Seroma formation and pain are frequent complications of moderate-large size laparoscopic direct inguinal hernia mesh repair. This study was conducted to evaluate the feasibility of defect closure in moderate-large direct inguinal hernias and its effect on various outcomes.

Uropathogens and their antimicrobial-resistant pattern among suspected urinary tract infections patients in eastern Nepal: A hospital inpatients-based study.

Background: Urinary tract infections are the primary factors that cause mortality and morbidity in patients with underlying comorbid conditions and are responsible for most hospital admissions worldwide.

Objectives: The study aims to identify the common bacterial uropathogens and determine their antimicrobial susceptibility pattern, including multidrug-resistant/extensively drug-resistant bacteria.

Methods: The descriptive cross-sectional study was conducted among inpatients provisionally suspected of urinary tract infections in the medical ward of Koshi Hospital, Biratnagar, Nepal.