Colon capsule endoscopy compared to conventional colonoscopy in patients with colonic diverticulitis: a randomised controlled superiority trial.

Background And Study Aim: Follow-up colonoscopy after an episode with colonic diverticulitis (CD) is standard in the Danish healthcare system to exclude malignancy. Colon capsule endoscopy (CCE) is a diagnostic alternative to colonoscopy. The purpose of this study was to compare CCE with colonoscopy after an episode with CD with primary focus on patient-reported outcomes.

Introducing colon capsule endoscopy as a new diagnostic modality for patients with bowel symptoms in general practice: a feasibility study.

Background: Bowel symptoms are common in general practice and though most often benign they can also indicate colorectal cancer where a colonoscopy often is required to rule out malignant disease. Colon capsule endoscopy (CCE) is suggested as a more patient-friendly alternative to colonoscopy but its application in symptomatic patients in general practice needs further investigation.

Materials And Methods: We present a feasibility study of integrating initial triage for CCE into general practice.

Choice of colon capsule or colonoscopy versus default colonoscopy in FIT positive patients in the Danish screening programme: a parallel group randomised controlled trial.

Background: Colonoscopy is among the standard tests for colorectal cancer (CRC) screening. However, uptake varies, and alternatives such as colon capsule endoscopy (CCE) are available. The uptake and detection rate of clinically significant neoplasia with CCE, compared with colonoscopy, remain unclear in this setting.

Short-term outcomes for intracorporeal vs. extracorporeal anastomosis in laparoscopic right hemicolectomy for colonic cancer-a prospective cohort study (ICEA-study).

Purpose: The purpose of this study is to compare short-term outcomes and 1-year incisional hernia rates between intracorporeal anastomosis (IA) and extracorporeal anastomosis (EA) in laparoscopic right hemicolectomy for management of right-sided colonic cancer. The primary outcome was the complication rate assessed by the comprehensive complication index (CCI). Secondary outcomes included time to bowel movement, length of hospital stay, 30-day readmission rate, early warning scores, and 1-year incisional hernia rate.

Towards full integration of explainable artificial intelligence in colon capsule endoscopy's pathway.

Despite recent surge of interest in deploying colon capsule endoscopy (CCE) for early diagnosis of colorectal diseases, there remains a large gap between the current state of CCE in clinical practice, and the state of its counterpart optical colonoscopy (OC). This is due to several factors, such as low quality bowel cleansing, logistical challenges around both delivery and collection of the capsule, and most importantly, the tedious manual assessment of images after retrieval. Our study, built on the "Danish CareForColon2015 trial (cfc2015)" is aimed at closing this gap, by focusing on the full integration of AI in CCE's pathway, where image processing steps linked to the detection, localization and characterisation of important findings are carried out autonomously using various AI algorithms.

Unifying terminology, reporting, and bowel preparation standards in colon capsule endoscopy: Nyborg Consensus.

Background And Study Aims: Colon capsule endoscopy (CCE) is becoming increasingly popular in Europe. However, development of quality assurance and standardized terminology has not kept pace with clinical integration of this technology. As a result, there are significant variations in reporting standards, highlighting the need for a standardized terminology and framework.

Bowel cleansing quality evaluation in colon capsule endoscopy: what is the reference standard?

Background: The diagnostic accuracy of colon capsule endoscopy (CCE) depends on a well-cleansed bowel. Evaluating the cleansing quality can be difficult with a substantial interobserver variation.

Objectives: Our primary aim was to establish a standard of agreement for bowel cleansing in CCE based on evaluations by expert readers.

Socioeconomic differences in discrepancies between expected and experienced discomfort from colonoscopy and colon capsule endoscopy.

Background: Social inequalities in colorectal cancer screening participation are evident. Barriers to screening participation include discomfort from diagnostic modalities. We aimed to describe the discomfort experienced from colonoscopy and colon capsule endoscopy (CCE) and investigate the discrepancy between expected and experienced discomfort stratified by socioeconomic status.

Rationalizing polyp matching criteria in colon capsule endoscopy: an international expert consensus through RAND (modified DELPHI) process.

Background: Colon capsule endoscopy (CCE) has gained momentum as an alternative modality for the investigation of the lower gastrointestinal tract. Of the few challenges that remain, the comparison and - eventually - matching of polyps at different timestamps leads to the potential for double reporting and can contribute to false-positive findings and inaccuracies. With the impending artificial intelligence integration, the risk of double reporting the same polyp due to the lack of information on spatial orientation underscores the necessity for establishing criteria for polyp matching.

Factors associated with negative colonoscopy in participants with a positive faecal immunochemical test from the Danish Colorectal Cancer Screening Program - a population-based study.

Aim: In the Danish Colorectal Cancer Screening Program (DCCSP), 37% of participants undergoing colonoscopy have a negative result with no obvious findings that can be attributed to a positive faecal immunochemical test (FIT). The aim of this work was to identify predictors for a negative colonoscopy in DCCSP participants with a positive FIT.

Method: We included 73 655 FIT-positive DCCSP participants using the Danish Colorectal Cancer Screening Database and linked their screening results with data from several other national health registers.

Colon CApsule endoscopy compared to conventional COlonoscopy in patients with colonic DIverticulitis: the study protocol for a randomised controlled superiority trial (CACODI trial).

Introduction: Follow-up after an episode of colonic diverticulitis is a common indication for colonoscopy, even though studies have shown a low risk of positive findings in this population. Our objective is to investigate colon capsule endoscopy (CCE) as a follow-up examination in patients with colonic diverticulitis compared with colonoscopy, particularly regarding patient satisfaction and clinical performance.

Methods And Analysis: We will conduct a single-centre prospective randomised controlled trial.

Socioeconomic differences in expected discomfort from colonoscopy and colon capsule endoscopy.

Individual income and educational level are associated with participation rates in colorectal cancer screening. We aimed to investigate the expected discomfort from the endoscopic diagnostic modalities of colonoscopy and colon capsule endoscopy in different socioeconomic groups as a potential barrier for participation. In a randomized clinical trial within the Danish colorectal cancer screening program, we distributed questionnaires to 2031 individuals between August 2020 and December 2022 to investigate the expected procedural and overall discomfort from investigations using visual analogue scales.

Colon capsule retention in a patient with large bowel stenosis due to diverticulosis - a case report.

Capsule retention is a rare complication to capsule endoscopy. It is often asymptomatic and resolves itself spontaneously. In some cases, endoscopy or surgery is necessary to remove the capsule.

The Effectiveness of a Very Low-Volume Compared to High-Volume Laxative in Colon Capsule Endoscopy.

Colon capsule endoscopy (CCE) is a promising modality for colonic investigations, but completion rates (CR) and adequate cleansing rates (ACR) must be improved to meet established standards for optical colonoscopy. Improvements should be made with patient acceptability in mind. We aimed to compare a very low-volume polyethylene glycol (PEG) laxative to a conventional high-volume laxative.

Castor Oil in Bowel Preparation Regimens for Colon Capsule Endoscopy: A Systematic Review with Meta-Analysis.

Completing colon capsule endoscopy (CCE) investigations rely on successful transit and acceptable bowel preparation quality. We investigated the effect of adding castor oil to the CCE bowel preparation regimen on the completion rate using a meta-analysis of existing literature. We conducted a systematic literature search in PubMed, Web of Science, and Embase.

Idiopathic asymptomatic pneumoperitoneum in a patient with ureteric calculus and Crohn's disease.

A 46-year-old male referred to the Emergency Department with pain in the left flank. The patient suffered from Crohn's disease. He had not experienced any fever, and a urine strip showed signs of blood.