Publications by authors named "Beatriz Martin-Adrados"
Introduction: The Unfolded Protein Response, a mechanism triggered by the cell in response to Endoplasmic reticulum stress, is linked to inflammatory responses. Our aim was to identify novel Unfolded Protein Response-mechanisms that might be involved in triggering or perpetuating the inflammatory response carried out by the Intestinal Epithelial Cells in the context of Inflammatory Bowel Disease.
Methods: We analyzed the transcriptional profile of human Intestinal Epithelial Cell lines treated with an Endoplasmic Reticulum stress inducer (thapsigargin) and/or proinflammatory stimuli.
Article Synopsis
- Acetaminophen (APAP) can cause severe liver damage by triggering endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in liver cells, but the detailed mechanisms behind this are not well understood.
- In studies using specific mice models, it was found that the activation of UPR and the JNK1/2 pathway were significant in APAP-induced liver toxicity, and that the XBP1 gene played a crucial role in this process.
- Blocking or reducing the activity of XBP1 in liver cells helped reduce liver injury by promoting autophagy and lowering the expression of CYP2E1, indicating potential new treatments for serious liver damage.
Binge drinking, i.e., heavy episodic drinking in a short time, has recently become an alarming societal problem with negative health impact.
View Article and Find Full Text PDFMonocyte-Derived Dendritic Cells Differentiated in the Presence of Lenalidomide Display a Semi-Mature Phenotype, Enhanced Phagocytic Capacity, and Th1 Polarization Capability.
Front Immunol
June 2018
Lenalidomide is an analog of thalidomide, with potent anticancer activity demonstrated in several hematological malignancies. It has immunomodulatory properties, being able to enhance the activation of different types of immune cells, which results in antitumor activities. Dendritic cells (DCs) are pivotal in the immune response, and different immunotherapeutic approaches targeting these cells are being developed.
View Article and Find Full Text PDFHuman Invariant Natural Killer T Cells Respond to Antigen-Presenting Cells Exposed to Lipids from Olea europaea Pollen.
Int Arch Allergy Immunol
August 2017
Article Synopsis
- This study investigates how olive pollen lipids affect human immune cells, particularly monocytes, macrophages (Mϕ), and dendritic cells (DCs), and their interaction with natural killer T (NKT) cells.
- Researchers extracted lipids from olive pollen and assessed their impact on the activation and phenotypic changes in these immune cells through various laboratory techniques.
- Findings indicate that olive pollen lipids can significantly enhance the activation of NKT cells and alter immune cell behavior, which may play a role in allergic reactions.