Primary Mediastinal Germ Cell Tumors: A Real-World Analysis of Clinical Characteristics, Treatment, and Survival Outcomes From Two Tertiary Cancer Centers in India.

Purpose: Mediastinal germ cell tumors (GCTs) are rare malignancies, predominantly affecting young males, with limited real-world data on treatment outcomes in India. This study aimed to evaluate the clinical characteristics, treatment patterns, and survival outcomes of patients with mediastinal GCTs, emphasizing the effectiveness of first-line chemotherapy regimens.

Methods: A retrospective analysis was conducted on 81 patients diagnosed with mediastinal GCTs at two tertiary cancer centers in India from 2005 to 2023.

Putative Mechanisms of Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Examined Using Magnetic Resonance Imaging.

Background: The neural mechanisms of electroconvulsive therapy (ECT) in refractory schizophrenia remain elusive. In the current study, we aimed to identify magnetic resonance imaging (MRI)-derived structural (cortical/subcortical volumes) and functional (resting-state connectivity) brain changes after ECT and their associations with clinical response.

Methods: We used an inductive (whole-brain, hypothesis-free) approach to examine structural and functional brain changes and their association with clinical response (positive symptom reduction) in clozapine-refractory schizophrenia ( = 30) after ECT (median 8 sessions).

The efficacy of add-on yoga intervention in somatoform pain disorders: An open-label controlled trial.

Background: Patients diagnosed with somatoform pain disorders (SPDs) experience chronic pain without any obvious etiology and repeatedly seek medical help to find some relief from the symptoms.

Aim: In this study, the effect of 24 weeks of add-on yoga therapy was assessed on pain in patients diagnosed with SPDs through an open-label trial.

Materials And Methods: Seventy subjects (42 women) with a group mean age ± standard deviation (SD) of 35.

Effect of Online Yoga on Child Health During COVID-19 Pandemic: A Qualitative Account from Parents.

An individual develops socioemotional and cognitive abilities during childhood and adolescence. The COVID-19 pandemic has had a negative effect on the physical, psychological, social, and cultural health of children. Yoga has been observed to be helpful for children in enhancing their physical and mental health during the COVID-19 pandemic.

Cross-cultural adaption of the computerized assessment of information processing battery (COGNITO) for an Indian longitudinal study on rural elderly.

Introduction: Testing cognitive functions in Indians with low literacy and linguistic diversity is challenging. We describe the adaptation process of a comprehensive neurocognitive test battery to suit both literate and illiterate aging rural Indians.

Methods: Following the International Test Commission (ITC) guidelines for cross-cultural adaptation, we adapted the COGNITO battery.