Quantifying the morphological variations of internal carotid artery in moyamoya angiopathy.

Aim: Moyamoya angiopathy (MMA) is characterised by the progressive narrowing and subsequent development of collateral blood vessels in the distal internal carotid artery (ICA) and its branches. This study investigates the influence of loss in ICA tortuosity and the role of morphological parameters of ICA subsegments in MMA.

Methods: This study utilised the 3D morphometric analysis of ICA models and its subsegments developed from magnetic resonance angiography to evaluate morphological variations in MMA.

Histopathology-based near-realistic arterial wall reconstruction of a patient-specific cerebral aneurysm for fluid-structure interaction studies.

Background And Objective: Cerebral aneurysms occur as balloon-like outpouchings in an artery, which commonly develop at the weak curved regions and bifurcations. When aneurysms are detected, understanding the risk of rupture is of immense clinical value for better patient management. Towards this, Fluid-Structure Interaction (FSI) studies can improve our understanding of the mechanics behind aneurysm initiation, progression, and rupture.

Patient-specific arterial wall generation for intracranial aneurysms with a variable and a near realistic vessel wall thickness for FSI studies.

Background And Objective: Imaging methodologies such as, computed tomography (CT) aid in three-dimensional (3D) reconstruction of patient-specific aneurysms. The radiological data is useful in understanding their location, shape, size, and disease progression. However, there are serious impediments in discerning the blood vessel wall thickness due to limitations in the current imaging modalities.