Rehabilitation across the Spectrum: A Case Series Evaluating a Structured Program for Knee Osteoarthritis and Musculoskeletal Impairments.

Knee osteoarthritis and related musculoskeletal conditions significantly impact mobility and independence in older adults. This prospective case series evaluated a 12-week structured physiotherapy program in five elderly women with diverse knee impairments. The program included six weeks of supervised rehabilitation followed by six weeks of home-based exercises.

Predicting yellow mosaic disease severity in yardlong bean using visible imaging coupled with machine learning model.

Accurate estimation of plant disease severity is pivotal for effective management and decision-making. Field experiments were conducted to understand the correlation and predict the yellow mosaic disease severity in yard-long beans using visible image indices. A total of 45 visible / Red Green Blue (RGB) indices were derived from the RGB images and correlated with disease severity, and also used as inputs for predicting disease severity using nine machine learning (ML) models.

Evaluation of lablab bean [ (L.) sweet] genotypes: unveiling superior pod yield, nutritional quality, and collar rot resistance.

Introduction: Malnutrition continues to be a significant concern at unacceptably high levels globally. There is significant potential for addressing malnutrition of human population through the biofortification of climate-resilient vegetables using strategic breeding strategies. Lablab bean [ (L.

Leveraging arsenic resistant plant growth-promoting rhizobacteria for arsenic abatement in crops.

Arsenic is a toxic metalloid categorized under class 1 carcinogen and is detrimental to both plants and animals. Agricultural land in several countries is contaminated with arsenic, resulting in its accumulation in food grains. Increasing global food demand has made it essential to explore neglected lands like arsenic-contaminated lands for crop production.

Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes.

Background: Globally, the current medical emergency for novel coronavirus 2019 (COVID-19) leads to respiratory distress syndrome and death.

Purpose: This review highlighted the effect of COVID-19 on systemic multiple organ failure syndromes. This review is intended to fill a gap in information about human physiological response to COVID-19 infections.

The debate over neurotransmitter interaction in aspartame usage.

Aspartame (NutraSweet®, Equal®) is a widely used artificial sweetener, has been reported to be accountable for neurological and behavioural disturbances in people. Upon ingestion, aspartame is hydrolyzed in gut and provides its metabolite; such as essential amino acid phenylalanine (Phy) (50%), aspartic acid (40%), and methanol (10%). Altered brain neurochemical compositions [such as dopamine (DA), norepinephrine (NE), and serotonin (5-HT)] have long been a concern and being involved in observed neurophysiological symptom (such as headaches, memory loss, mood changes, as well as depression) in aspartame consumers.

Revisiting the safety of aspartame.

Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. Since 1981, when aspartame was first approved by the US Food and Drug Administration, researchers have debated both its recommended safe dosage (40 mg/kg/d) and its general safety to organ systems. This review examines papers published between 2000 and 2016 on both the safe dosage and higher-than-recommended dosages and presents a concise synthesis of current trends.

Characterization of CcSTOP1; a C2H2-type transcription factor regulates Al tolerance gene in pigeonpea.

Al-responsive citrate-transporting CcMATE1 function and its regulation by CcSTOP1 were analyzed using NtSTOP1 -KD tobacco- and pigeonpea hairy roots, respectively, CcSTOP1 binding sequence of CcMATE1 showed similarity with AtALMT1 promoter. The molecular mechanisms of Aluminum (Al) tolerance in pigeonpea (Cajanus cajan) were characterized to provide information for molecular breeding. Al-inducible citrate excretion was associated with the expression of MULTIDRUGS AND TOXIC COMPOUNDS EXCLUSION (CcMATE1), which encodes a citrate transporter.

Aspartame: Should Individuals with Type II Diabetes be Taking it?

Background: Individuals with Type II Diabetes (T2D) have to manage blood glucose levels to sustain health and longevity. Artificial sweeteners (including aspartame) are suggested sugar alternatives for these individuals. The safety of aspartame in particular, has long been the centre of debate.

Neurophysiological symptoms and aspartame: What is the connection?

Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia. The consumption of aspartame, unlike dietary protein, can elevate the levels of phenylalanine and aspartic acid in the brain.

Sleep restriction may lead to disruption in physiological attention and reaction time.

Sleepiness is the condition where for some reason fails to go into a sleep state and will have difficulty in remaining awake even while carrying out activities. Sleep restriction occurs when an individual fails to get enough sleep due to high work demands. The mechanism between sleep restriction and underlying brain physiology deficits is not well assumed.

Effects of aspartame on hsp70, bcl-2 and bax expression in immune organs of Wistar albino rats.

Aspartame, a "first generation sweetener", is widely used in a variety of foods, beverages, and medicine. The FDA has determined the acceptable daily intake (ADI) value of aspartame to be 50 mg/kg·day, while the JECFA (Joint FAO/WHO Expert Committee on Food Additives) has set this value at 40 mg/kg of body weight/day. Safety issues have been raised about aspartame due to its metabolites, specifically toxicity from methanol and/or its systemic metabolites formaldehyde and formic acid.

A Comparative Analysis of Dietary Habits on Sensory Motor Association and Heart Rate Variability during Menstrual Cycle.

Introduction: Dietary habits can make a big difference on both physical and mental aspects of the body. Menstrual disorder frequently affects the quality of life of adolescent and young adult women. Menstrual cycle irregularities may be associated with psychological stress, and endocrine disturbances.

Longer period of oral administration of aspartame on cytokine response in Wistar albino rats.

Introduction: Aspartame is a non-nutritive sweetener particularly used in 'diet' and 'low calorie' products and also in a variety of foods, drugs and hygiene products. Aspartame is metabolized by gut esterases and peptidases to three common chemicals: the amino acids, aspartic acid and phenylalanine, and small amounts of methanol. The aim of the present study was to assess potential changes in molecular mediators of aspartame as a chemical stressor in rats.

Screening of pigeonpea genotypes for nutrient uptake efficiency under aluminium toxicity.

For increasing pigeonpea production in India, it is necessary to expand its area in non-traditional areas such as north-eastern states, which have considerable area under acidic soils. In such soils, aluminium toxicity, which is a major yield limiting factor, interferes with nutrient uptake efficiency of crop plants. 32 genotypes of pigeonpea [Cajanus cajan (L.