Novel patient-specific BBSOAS mouse models reveal genotype-phenotype correlations in brain structure and behavior.

Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is a rare, autosomal dominant neurodevelopmental disorder caused by pathogenic variants in NR2F1, characterized by developmental delay, intellectual disability, optic nerve anomalies, and autism spectrum disorder. Most pathogenic variants cluster within the highly conserved DNA-binding domain (DBD) or ligand-binding domain (LBD) of NR2F1 and are associated with variable clinical severity, suggesting a genotype-phenotype correlation. While previous mouse models have provided important insights, comprehensive behavioral characterization remains limited.

Evaluation of Superior Laryngeal Nerve Block for Management of Laryngeal Sensory Neuropathy.

Laryngeal sensory neuropathy (LSN) is an under-recognized cause of chronic laryngopharyngeal symptoms, including cough. This study aimed to investigate the role of superior laryngeal nerve (SLN) block in the management of LSN.A prospective interventional study was conducted at a tertiary care center over two years (January 2023 to December 2024).

Systemic Lupus International Collaborating Clinics-Frailty Index predicts hospitalisations in the Almenara Lupus Cohort.

Objectives: To evaluate the Systemic Lupus International Collaborating Clinics-Frailty Index (SLICC-FI) as a predictor of hospitalisations in patients with SLE from a Latin American cohort.

Methods: Patients from a single-centre prevalent cohort were included. The SLICC-FI was assessed at baseline.

Tracheo-Innominate Artery Fistula: A Systematic Review of Diagnostic and Management Strategies.

Objective: Tracheo-innominate artery fistula (TIF) is a rare but devastating complication of tracheostomy. A systematic review was performed with the aim of identifying the factors associated with favorable outcomes in cases of TIF post-tracheostomy.

Data Sources: Literature search conducted using PubMed/Medline, Semantic Scholar, OpenAlex, Scopus, and Google Scholar.

A comparison of surgical outcomes of endoscopic versus microscopic myringoplasty.

Background: There is a gradual transition from open to minimal access surgeries in Otorhinolaryngology. Myringoplasty can be done with either microscope or endoscope. Use of both the techniques has been reported in literature.

Systemic Lupus International Collaborating Clinics Frailty Index Predicts Worsening Health-Related Quality of Life, Data From the Almenara Lupus Cohort.

Objective: The Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) as a predictor of quality of life (QoL) in patients with systemic lupus erythematosus (SLE) has not been evaluated longitudinally. We estimated the association of SLICC-FI scores with future QoL in our prevalent Latin American Mestizo cohort.

Methods: Patients from a single-center SLE cohort were included.

Refractory Secondary Hyperparathyroidism in Chronic Renal Impairment: Is Surgery a Viable Option to Achieve a Biochemical Balance in Patients Failing Medical Management?

Secondary hyperparathyroidism (SHPT) is a common complication in chronic kidney disease patients, necessitating effective management to prevent adverse outcomes. This study evaluates the efficacy of surgical intervention in achieving biochemical balance in SHPT patients resistant to medical therapy. The study includes 36 patients with SHPT who underwent subtotal parathyroidectomy following failed medical management.

Amaurosis fugax in Takayasu arteritis mimicking migraine with visual aura.

Takayasu arteritis is a rare vasculitis commonly seen in young women. Amaurosis fugax and headache are visual presentations of Takayasu arteritis. Migraine with visual aura is a common condition affecting young women, and differentiating migraine from Takayasu presenting with visual symptoms and headache can be challenging.

Giant Angina Bullosa Hemorrhagica of Hard Palate: A Case Report.

Angina Bullosa Hemorrhagica is characterized with rapid appearance of soft, blood-filled blisters on the mucosa of oral cavity and oropharynx. It is a benign condition, and is not associated with any systemic hematological disorder. No etiological factors have been identified and there are no established guidelines for its management.

Are conversation and whispered voice hearing tests comparable to pure tone audiometry for assessment of hearing loss? A retrospective analysis.

Background: Pure tone audiometry (PTA) is considered the standard method of hearing assessment. However, technical and logistical challenges preclude its usage for hearing screening at primary healthcare facilities. Free field hearing (FFH) tests such as conversation voice (CV) and whispered voice (WV) tests have been used for hearing assessment.

A survey of awareness, knowledge, attitude, and skills of telemedicine among healthcare professionals in India.

Background: Telemedicine Practice Guidelines were promulgated in India in 2020. There is little information about the awareness, knowledge, attitude and skills (AKAS) of the healthcare professionals regarding telemedicine and its practice guidelines a year after. The aim of the study was to study the awareness, knowledge, attitudes and skills of the healthcare workers of the country about telemedicine especially in the context of telemedicine practice guidelines 2020.

Hemangioma - A Rare Cause of Laryngeal Growth in an Adult and its Management with Sclerotherapy and Laser Surgery: A Case Report.

Hemangiomas are benign tumors of vascular origin commonly affecting head and neck region. Laryngeal Hemangiomas are however rare and have no well-defined management protocols. We present an interesting case of a 42-year-old adult who was diagnosed as a case of Laryngeal Hemangioma based on clinical and radiological findings and was managed with local injection of sclerosing agent followed by CO Laser fulguration.

The Use of a Low-Cost Gaming Platform as a Substitute to Medical-Grade Force Plate in Objective Evaluation of Balance.

Posturography is a tool for quantitative measurement of balance in various static and dynamic test conditions. Current medical grade Posturography systems are very costly and rare outside research institutes. The Wii Balance Board is an inexpensive gaming device which works on similar principles and uses the center of pressure of an individual as an input for motion-controlled gaming.

COBERT: COVID-19 Question Answering System Using BERT.

In the current situation of worldwide pandemic COVID-19, which has infected 62.5 Million people and caused nearly 1.46 Million deaths worldwide as of Nov 2020.

Colonisation and Transmission Dynamics of among Chronic Respiratory Diseases Patients Hospitalised in a Chest Hospital, Delhi, India: A Comparative Analysis of Whole Genome Sequencing and Microsatellite Typing.

is a nosocomial pathogen responsible for an expanding global public health threat. This ascomycete yeast has been frequently isolated from hospital environments, representing a significant reservoir for transmission in healthcare settings. Here, we investigated the relationships among isolates from patients with chronic respiratory diseases admitted in a chest hospital and from their fomites, using whole-genome sequencing (WGS) and multilocus microsatellite genotyping.

The infodemics of COVID-19 amongst healthcare professionals in India.

Background: There is a deluge of information and misinformation about COVID-19. The present survey was conducted to explore the sources of information /misinformation for healthcare professionals from India.

Methods: A cross-sectional online survey using snowballing technique was conducted from 24 Mar to 10 Apr 2020.

Unilateral Sudden Sensorineural Hearing Loss: A Rare Presentation of Cerebral Venous Thrombosis.

Sudden sensorineural hearing loss (SNHL) is postulated to be caused due to a multitude of factors, but a definitive cause is seldom found despite extensive investigations. We present a rare case of sudden SNHL in which central venous thrombosis was found on magnetic resonance imaging. The case highlights the importance of neuroimaging in all cases of sudden SNHL before being labelled as "idiopathic" so that targeted therapy can be given.

Vestibular Dysfunction in Children Suffering from Otitis Media with Effusion: Does Grommet Help? An Observational Study Using Computerized Static Posturography.

Otitis media with effusion (OME) has a detrimental effect on balance, which may not present as a clear symptom in children. This effect can be improved by the insertion of ventilation tubes. This study assesses balance in children suffering from OME pre and post operatively using computerized static posturography.

Comparing different dehydration methods on protein quality of krill (Euphausia Pacifica).

Krill, (Euphausia pacifica) contains a high protein content (>15.4%) and an estimated biological value higher than many animal protein sources. Thus it is considered to be an important source of high-quality protein.

Post Stapedotomy Vestibular Deficit: Is CO Laser Better than Conventional Technique? A Non-randomized Controlled Trial.

The current standard of care for surgical management of Otosclerosis is small fenestra stapedotomy, which can be done by CO Laser assisted as well as conventional techniques. Vertigo is the commonest complication after stapes surgery. The use of CO Laser has been rising recently owing to its no touch principle, high precision and possibly lower risk of vertigo post operatively.

Effect of processing conditions on quality of green beans subjected to reciprocating agitation thermal processing.

The effect of reciprocating agitation thermal processing (RA-TP) on quality of canned beans was evaluated in a lab-scale reciprocating retort. Green beans were selected due to their soft texture and sensitive color. Green beans (2.

Heat transfer phenomena during thermal processing of liquid particulate mixtures-A review.

During the past few decades, food industry has explored various novel thermal and non-thermal processing technologies to minimize the associated high-quality loss involved in conventional thermal processing. Among these are the novel agitation systems that permit forced convention in canned particulate fluids to improve heat transfer, reduce process time, and minimize heat damage to processed products. These include traditional rotary agitation systems involving end-over-end, axial, or biaxial rotation of cans and the more recent reciprocating (lateral) agitation.

Response surface optimization of medium components for naringinase production from Staphylococcus xylosus MAK2.

Response surface methodology was used to optimize the fermentation medium for enhancing naringinase production by Staphylococcus xylosus. The first step of this process involved the individual adjustment and optimization of various medium components at shake flask level. Sources of carbon (sucrose) and nitrogen (sodium nitrate), as well as an inducer (naringin) and pH levels were all found to be the important factors significantly affecting naringinase production.