Exploring Molecular Characteristics and Therapeutic Strategies for Primary Sinonasal Mucosal Melanoma with Distant Metastasis.

Sinonasal mucosal melanoma (SNMM) is a rare aggressive malignancy of the sinonasal tract. Due to its advanced clinical presentation and frequent late-stage diagnosis, the 5-year survival rate is less than 30%, with an even worse prognosis in patients with distant metastasis (SNMM-M). Therefore, characterizing the molecular landscape of SNMM may provide novel therapeutic targets for SNMM-M.

Global phylogeography and microdiversity of the marine diazotrophic photoautotrophs and UCYN-A.

Photoautotrophic diazotrophs, specifically the genera and UCYN-A, play a pivotal role in marine nitrogen cycling through their capacity for nitrogen fixation. Despite their global distribution, the microdiversity and environmental drivers of these diazotrophs remain underexplored. This study provides a comprehensive analysis of the global diversity and distribution of and UCYN-A using the nitrogenase gene () as a genetic marker.

Targeting Artemis Sensitizes B Cells to Topoisomerase 2 Poisons by Disrupting DNA-PKcs-Dependent Repair.

Topoisomerase 2 (Top2) poisons are widely used in cancer therapy but are associated with toxicity and secondary malignancies. Removing Top2 adducts requires endonuclease activity and repair by non-homologous end joining (NHEJ). We show that the NHEJ enzyme Artemis is a promising target for co-treatment with Top2 poisons.

Global Phylogeography and Microdiversity of the Marine Diazotrophic Cyanobacteria and UCYN-A.

Cyanobacterial diazotrophs, specifically the genera and UCYN-A, play a pivotal role in marine nitrogen cycling through their capacity for nitrogen fixation. Despite their global distribution, the microdiversity and environmental drivers of these diazotrophs remain underexplored. This study provides a comprehensive analysis of the global diversity and distribution of and UCYN-A using the nitrogenase gene ( ) as a genetic marker.

Managing demand volatility during unplanned events with sentiment analysis: a case study of the COVID-19 pandemic.

Unplanned events such as natural disasters or epidemic outbreaks are usually accompanied by supply chain disruption and highly volatile markets. Besides, the recent COVID-19 crisis has shown that existing artificial intelligence systems and data analytics models, which normally provide valuable support in demand forecasting, have not been able to manage demand volatility. This study contributes addressing this issue and aims to determine whether sentiments conveyed by news media influence consumer behavior.

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways.

OBJECTIVE Defects in the apoptotic machinery and augmented survival signals contribute to drug resistance in glioblastoma (GBM). Moreover, another complexity related to GBM treatment is the concept that GBM development and recurrence may arise from the expression of GBM stem cells (GSCs). Therefore, the use of a multifaceted approach or multitargeted agents that affect specific tumor cell characteristics will likely be necessary to successfully eradicate GBM.