Consensus conference results on contraception in women beyond 40 years of age.

The objective is to develop expert consensus to inform clinical decision-making in the use of hormonal contraceptives in women over 40 years of age. A multidisciplinary panel organised by the Italian Society of Contraception performed a systematic literature review up to October 2024, defining the priorities in the choice of a contraceptive and its effects on cardiovascular risk, menstrual bleeding, bone health, and sexual function associated with hormonal contraception in women over 40. Statements summarising the findings were discussed and refined in a dedicated expert meeting.

Quality of life, sexual function and metabolic parameters of women during 10 years of using the etonogestrel implant.

Objective: To study the effects on the quality of life (QoL), sexual function and metabolic aspects in women using a subcutaneous implant containing Etonogestrel (ENG-implant) over 10 years of observation period.

Study Design: This study was performed from January 2011 to September 2023. A database was set up to collect data from women.

Defining the "normal uterus" by ultrasound measurement of uterine lengths, thicknesses, and angles in a population of nulliparous women: the Normal UteRus asSEssment study.

Objective: The existing classifications of congenital uterine anomalies are inconsistent and subject to criticism for various reasons. Noteworthy, there is still no universally accepted definition of normal uterus (NU) based on ultrasound measurements, making it difficult to objectively distinguish the uterine anatomical variants within the population. The purpose of the Normal UteRus asSEssment study was to define the exact three-dimensional (3D) ultrasound measurements of an NU, in terms of uterine lengths, thicknesses, and angles.

Vaginal contraception with NuvaRing decreases symptoms and uterine features of adenomyosis: A prospective evaluation.

Objective: We aimed to assess the effects of contraception with NuvaRing on ultrasound signs and symptoms of women with adenomyosis.

Study Design: We conducted a prospective self-controlled observational study on women with adenomyosis who required contraception with NuvaRing. Exclusion criteria were actual use or contraindications to hormonal contraception.

Targeting vasomotor symptoms with the new drug fezolinetant - an expert overview.

Menopause is an inevitable event in the life of women who live long enough to reach this milestone. The experience of menopause varies amongst individuals. Menopause has a negative impact on women's life and is associated with symptoms including vasomotor symptoms (VMS), such as hot flushes and night sweats, sleep disturbances and low mood.

A role of the uterine cervix in the pathogenesis of adenomyosis and endometriosis?

Data indicate a link between the cervix and pathologies like adenomyosis and endometriosis. Uterine flexion on the cervix, diameter and stiffness of the internal cervical orifice represent an obstacle to downstream menstrual flow, that when excessive increases the intensity of uterine contractions. Evidence indicates that intense uterine contractions damage the endometrial myometrial junction, favoring endometrial entrance into the myometrium, to induce adenomyosis, and retrograde menstrual flow into the peritoneal cavity, to induce endometriosis.

Persistent gaps in menopause care: current recommendations of the POESIT group.

In recent years, menopause awareness has been increasing in several European countries; however, gaps in menopause knowledge, attitudes and practices persist. This review provides an overview of the women's current menopausal experience in Italy, Spain and Portugal, and gives POESIT (Portugal + Spain + Italy) group recommendations to address persistent barriers in menopause care. The perception, occurrence and impact of menopause symptoms vary among countries, with genitourinary syndrome of menopause and vasomotor symptoms being the most frequent overall.

Combined oral contraceptive prescription patterns for therapeutic purposes: results from a subanalysis of the multinational PRO-E2 study.

Purpose: To investigate prescription for therapeutic purposes of combined oral contraceptives (COCs) in countries of the PRO-E2 study, with a special focus on Italy.

Methods: Therapeutic reasons for prescription of COCs currently approved with no therapeutic the sole contraceptive indication, such as associations of nomegestrol acetate plus oestradiol and levonorgestrel plus ethynylestradiol, were investigated in the overall population (Italy excluded) ( = 71,630) and, separately, the Italian subpopulation ( = 19,683) of PRO-E2 study.

Results: COC prescription for contraception only was 38.

Pilot Clinical and Radiomic Analysis of Deep Infiltrating Endometriosis of the Parametrium Using Shannon Entropy: A Retrospective Cohort Study.

Objective: Ultrasound techniques for diagnosing deep infiltrating endometriosis (DIE) currently lack a quantitative method to assess microstructural heterogeneity in relation to diagnosis and clinical symptoms. This study evaluates Shannon entropy-based radiomics for differentiating DIE lesions from adjacent tissue and correlating these features with pain severity.

Methods: In this retrospective cohort study (2020-2024), fertile women with histologically confirmed parametrial endometriosis and high-quality ultrasound images were evaluated.

Effects of a Monophasic Hormonal Contraceptive With Norgestimate+Ethinyl Estradiol on Menstrual Bleeding: Protocol and Design of a Multicenter, Prospective, Open-Label, Noncomparative Study in Italy.

Background: Norgestimate (NGM) is a progestin with negligible androgenic activity that is available in combination with ethinyl estradiol (EE) as a monophasic combined oral contraceptive (COC). It has been more than 30 years since a clinical study evaluated the effects of monophasic NGM/EE on menstrual cycle characteristics in healthy women, and in the interim, there has been growing recognition that clinical trials of contraceptives should evaluate a wide range of potential positive and negative impacts for users.

Objective: The aim of this study is to investigate menstrual cycle control during the use of a monophasic COC formulation containing NGM 0.

Evaluation of Long-COVID Syndrome in a Cohort of Patients with Endometriosis or Adenomyosis.

: Long-COVID is characterized by the persistency of COVID-19 symptoms beyond 12 weeks, and it is probably consequent to immune dysregulation induced by SARS-CoV-2 infection. Immune dysregulation is associated with and probably involved in the pathogenesis of chronic gynecological conditions like endometriosis and adenomyosis. This study evaluated whether the presence of endometriosis or adenomyosis increases the risk of long-COVID, i.

Effect of Maternity Units' Organizational Levels on Maternal Birth Satisfaction: A Multicentric Cohort Study.

Introduction: Maternal birth satisfaction is correlated to long-term outcomes and is influenced by the place of birth. In Italy, most births occur in hospitals. Our study aimed to assess whether the organizational level (I vs.

Expert opinion by the Italian Society of Gynecology of the Third Age (SIGiTE) and the Italian Society of Menopause (SIM) on hormone therapy with bioidentical hormones.

The publication of the study WHI (Women's Health Initiative) represented a critical moment for the management of menopause considering the alarming results about breast cancer and cardiovascular risks. Anyway, several further studies progressively clarified over time the effective clinical impact of hormone replacement therapy (HRT) among post-menopausal women if adequately started before the age of sixty and no more than ten years after the last menstrual cycle and properly customized according to the major international recommendations. Robust evidence exists on different approved bioidentical HRT (abHRT) but data about galenic composed bioidentical hormone therapy (cbHRT) remain poor.

Vaginal oxygen plus hyaluronic acid on lower urinary tract symptoms in breast cancer survivors.

Objective: This study aimed to evaluate the effect of vaginal oxygen and hyaluronic acid on lower urinary tract symptoms (LUTS) in breast cancer survivors.

Method: A prospective trial was conducted at a university hospital's Menopause Outpatient Clinic. Breast cancer patients experiencing LUTS received intravaginal natural oxygen for 15 min, coupled with a 2% hyaluronic acid solution during the last 5 min.

Hormonal Contraception and Bone Metabolism: Emerging Evidence from a Systematic Review and Meta-Analysis of Studies on Post-Pubertal and Reproductive-Age Women.

Background/objectives: This study aims to assess the effects of combined hormonal contraceptives (CHCs) on bone metabolism markers. It primarily measures osteocalcin and additionally examines other bone health markers, seeking to determine their responses to estrogen-progestogen treatments.

Methods: This study involved a comprehensive evaluation of the pertinent literature and a meta-analysis explicitly conducted on data describing women of reproductive age.

Menopausal symptoms in breast cancer survivors on adjuvant endocrine therapy compared with those of menopausal women.

Objectives: To compare menopausal symptoms of breast cancer survivors on adjuvant endocrine therapy with those of menopausal women.

Study Design: In a retrospective nested case-control study menopausal symptoms were compared of breast cancer survivors in pre-, peri- or post-menopause at the time of diagnosis, on tamoxifen or an aromatase inhibitor, plus a gonadotrophin-releasing hormone analogue, if pre- or peri-menopausal, and age-matched control women either in the late peri-menopause, or in surgical or in physiological post-menopause on no hormone replacement therapy. Differences between women on tamoxifen and those on aromatase inhibitors were also evaluated.

Ospemifene and vulvovaginal atrophy: an update of the clinical profile for post-menopausal women.

Introduction: The demand for effective and safe treatments of genitourinary syndrome (GSM) in post-menopausal women (PMW) is growing. Published data on the efficacy and safety of ospemifene (OSP) prompt an updated literature review to enlighten possible improvements in the GSM treatment.

Area Covered: We searched articles published in English from 2010 to 2023 through Medline (PubMed) and Embase databases with Boolean terms: OSP, PMW, GSM, endometrium, breast cancer, cardiometabolic syndrome, bone metabolism, adherence to treatment, and patient satisfaction.

POESIT recommendations on management of body-identical hormones in menopausal symptoms.

Many women seek treatment to improve menopausal vasomotor symptoms (VMS). The selection of women most likely to benefit from menopause hormone therapy (MHT) is crucial in clinical practice. There is general agreement that women younger than 60 years or who initiate MHT within the first 10 years of menopause, with no contraindications, have greater benefits considering symptomatic relief and additional advantages.