Publications by authors named "Andre Cabie"
Correspondence on "Epidemiology of rheumatic diseases in tropical populations" by Goyal & Santhanam.
Best Pract Res Clin Rheumatol
May 2025
We investigated whether baseline levels of biomarkers related to endotheliopathy, thromboinflammation, and fibrosis were associated with clinical outcomes in hospitalized COVID-19 patients. We analyzed the associations between baseline levels of 21 biomarkers and time to hospital discharge and change in NEWS-2 score in patients from DisCoVeRy trial. We fitted multivariate models adjusted for baseline ISARIC 4C score, disease severity, D-dimer values, and treatment regimen.
View Article and Find Full Text PDF[The dengue vaccine: a major scientific challenge and a public health issue].
Med Sci (Paris)
October 2024
Almost half of the world's population is exposed to the risk of transmission of the four dengue virus serotypes (DENV 1-4), by mosquitoes of the genus Aedes. A dengue vaccine is effective if it induces prolonged protective immunity against all circulating viral strains, irrespective of the age and infection history of the vaccinated subject. An effective vaccine strategy against dengue is based on the injection of live attenuated viruses in a tetravalent formulation.
View Article and Find Full Text PDFArticle Synopsis
- The European Union includes 30 outermost and overseas countries and territories (OCTs), where renal transplantation is growing, but many patients still seek treatment in continental Europe, necessitating collaborative care.
- Each OCT has its own infectious disease patterns, which are crucial for ensuring effective post-transplant care for kidney transplant recipients (KTRs).
- The paper suggests a practical approach to enhance pre-transplant evaluations and provides region-specific epidemiological data, advocating for more collaborative research among the OCTs to improve care for infected KTRs.
Nearly 4 billion people live in a dengue risk area worldwide. The prevalence of dengue-related mucocutaneous manifestations and their association with severe dengue differ across studies. The aim of the study was to describe the characteristics of patients with dengue-related mucocutaneous manifestations and to investigate those were associated with severe dengue.
View Article and Find Full Text PDFLiver involvement is an unusual yet frequently overlooked dengue complication. Pivotal for an efficient clinical management, the early diagnosis of dengue-associated liver involvement relies on an accurate description of its clinical and biological characteristics, its prognosis factors, its association with severe dengue and its clinical management. We conducted a systematic review by searching PubMed and Web of Science databases for original case reports, cohort and cross-sectional studies reporting the clinical and/or biological features of dengue-associated liver involvement.
View Article and Find Full Text PDFArticle Synopsis
- - In 2023, dengue virus serotype 2 (DENV2) spread widely across French overseas territories, with over 30,000 suspected cases in the French Caribbean by March 2024.
- - Genome analysis shows that the DENV2 lineage in the Caribbean is now also found in French Guiana and has led to local cases in mainland France, but not in Réunion.
- - To prevent the further spread of the virus and its introduction in new areas, ongoing molecular monitoring and mosquito control efforts are crucial.
Article Synopsis
- APOBEC3 proteins create some damaged HIV viruses in people who are infected, and this study looked at how these changed when patients switched treatments to dolutegravir and lamivudine.
- Researchers collected blood samples from patients before and after starting the new treatment and found that the number of defective viruses wasn't drastically lower after a year, but more patients had certain mutations related to drug resistance.
- Overall, they noticed changes in the mutations, but more research is needed to see what happens in the long run.
Dengue fever has been a public health problem in the Caribbean region since 1981, when it first reappeared in Cuba. In 1989, it was reported in Martinique and Guadeloupe (two French islands 200 km apart); since then, DENV has caused several epidemics locally. In 2019-2021, DENV-1, DENV-2, and DENV-3 were detected.
View Article and Find Full Text PDFObjective: Evaluate whether prefrail and frail people with HIV (PWH) have a higher risk of cognitive impairment on screens.
Methods: Analysis of PWH aged 70 or older included in the ANRS EP66 SEPTAVIH cohort, on antiretroviral therapy for at least 12 months and with a MoCA test at enrolment. Adjusted risk of a Montreal Cognitive Assessment (MoCA) less than 26 was compared in frail/prefrail versus robust PWH.
Article Synopsis
- The study aimed to analyze scientific publications from the French West Indies (FWI) and the Dominican Republic (DR) from 1990-2019, focusing on trends, international collaborations, and potential future partnerships.
- A total of 3,599 publications were examined, with the FWI contributing 2,552 articles and the DR 1,047; the majority of these were published in high-quality journals.
- Key collaborative partners included mainland France for the FWI and the US for the DR, with a notable focus on infectious diseases like arboviruses and HIV, suggesting a solid foundation for future research collaborations in this area.*
Article Synopsis
- There's been a significant rise in dengue virus (DENV) cases and deaths in the southwestern Indian Ocean, particularly on Reunion Island and Seychelles, with notable shifts in the viral strains from DENV-2 to DENV-1 between 2017 and mid-2021.
- Researchers extracted nucleic acids from blood samples of dengue-positive patients to identify DENV-1 and sequenced the genomes using advanced technology to analyze their characteristics and origins.
- The findings showed that Reunion's DENV-1 strains were closely related to a 2020 isolate from Sri Lanka and exhibited genetic mutations, while Seychelles' strains formed distinct clusters related to isolates from Bangladesh and Singapore, indicating a divergence in the genetic evolution of these outbreaks.
Associated risk factors of severe dengue in Reunion Island: A prospective cohort study.
PLoS Negl Trop Dis
April 2023
Background: Since 2018, a dengue epidemic has been raging annually in Reunion Island, which poses the major problem of its morbidity and mortality. However, there is no consensus in the literature on factors associated with severity of illness. The objective of this study was to identify the factors associated with the occurrence of severe dengue (SD) according to the criteria adopted in 2009 by the World Health Organization (WHO), during the 2019 epidemic.
View Article and Find Full Text PDFObjectives: To minimize confounding factors, we aimed to describe the changes in weight and body mass index (BMI) following the single substitution of tenofovir disoproxil fumarate (TDF) by tenofovir alafenamide (TAF) in people living with HIV (PLWH).
Methods: We designed a retrospective study in a large French cohort. We included all HIV-suppressed adults under TDF + emtricitabine + rilpivirine or elvitegravir/cobistat, who experienced a first switch from TDF to TAF, while other antiretrovirals remained unchanged (Switch group).
Low-level viral loads and virological failure in the integrase strand transfer era.
J Antimicrob Chemother
April 2023
Article Synopsis
- The study aimed to analyze how low-level viral load (LLVL) relates to virological failure (VF) in patients starting antiretroviral therapy (ART) with an integrase strand transfer inhibitor (INSTI) between 2015 and 2020.
- The analysis included 3,302 patients and found that 13.7% experienced LLVL and 11% had VF, with LLVL significantly associated with an increased risk of VF.
- The results suggest that any viral load above 50 copies/mL should prompt better adherence support, indicating that LLVL has negative implications even if VF doesn’t occur.
Article Synopsis
- - The study aimed to compare the outcomes of patients infected with Omicron BA.1 and BA.2 who were treated with either sotrovimab or nirmatrelvir to prevent severe COVID-19.
- - Of the 255 patients analyzed, nirmatrelvir resulted in faster negative PCR conversion (4 days) compared to sotrovimab (11.5 days), and a lower hospitalization rate was observed in nirmatrelvir-treated patients.
- - The findings suggest that nirmatrelvir may lead to quicker viral clearance than sotrovimab in high-risk patients, potentially reducing the spread of the virus.
We aimed to describe adverse pregnancy outcomes among women who had symptomatic, RT-PCR-confirmed ZIKV infection and early childhood outcomes among their infants. We enrolled pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection in a prospective cohort study, and their infants in a prospective pediatric cohort study. We defined adverse pregnancy and early childhood outcomes based on selected neurologic, ophthalmologic, auditory, musculoskeletal, and anthropometric abnormalities.
View Article and Find Full Text PDFObjectives: In COVID-19 patients, bacterial and fungal pulmonary coinfections, such as , , , or have been reported, but to our knowledge, no case has been reported due to .
Patients And Methods: We describe three cases of coinfections occurring during the 4th wave of COVID-19 in Martinique (French West Indies).
Results: All three cases were fatal; thus, has to be considered as a potentially severe coinfection agent.
The Role of Heterogenous Real-world Data for Dengue Surveillance in Martinique: Observational Retrospective Study.
JMIR Public Health Surveill
December 2022
Article Synopsis
- Traditional dengue control relies on vector control and case reporting, which can be slow and often underestimates the disease burden, especially in smaller regions like Martinique.
- This study investigates the use of diverse data sources, including hospitalization records and Google Trends, to improve dengue tracking and reduce reporting delays on the island.
- Findings indicate that real-world data can enhance dengue surveillance, as certain indicators, like hospitalization rates, show strong correlations with dengue outbreaks, allowing for earlier detection of rising case numbers.
Background: Smoking influence on poststroke prognosis remains controversial. These conflicting results could be due to some residual confounding factors not fully considered in previous studies, including social deprivation. This study aimed to assess the joint impact of deprivation and smoking on functional outcomes after ischemic stroke.
View Article and Find Full Text PDFArticle Synopsis
- A study examined the long-term symptoms of COVID-19 in patients 12 months after hospitalization, finding that 27% experienced three or more persistent symptoms, mainly fatigue, dyspnoea, and joint pain.
- The research included 737 participants, with a notable difference in outcomes based on gender; women reported more persistent symptoms, anxiety, and depression compared to men.
- Despite recovery progress, many who were employed before hospitalization still faced challenges, as 27% remained on sick leave at the 12-month mark, highlighting the ongoing impact of COVID-19 on quality of life.
Importance: Most ocular lesions have been described for children with congenital Zika syndrome. The frequency of finding ocular abnormalities is unknown among children exposed to Zika virus (ZIKV) during pregnancy. This study was conducted on newborns whose mothers were positive for ZIKV, confirmed with reverse-transcription polymerase chain reaction (RT-PCR) testing.
View Article and Find Full Text PDF