Publications by authors named "Alice Beattie"

In this latest update, we explore the recent announcement by Canada's Drug Agency (CDA-AMC, formerly CADTH) on their pilot to include the societal perspective in the evaluation of certain new medicines; a recent Office of Health Economics (OHE) report on the evaluation of HTA agency methods over time; and publications examining the impact of Project Orbis on patient access to oncology treatments.

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In this latest update, we look at recent developments in market access including the pricing agreement of Libmeldy by the Beneluxa Initiative, the financial impact of managed entry agreements in Italy and the restructuring of Agenzia Italiana del Farmaco (AIFA). We also highlight the collaboration between FINOSE and the New Expensive Drug (NED) section of the Nordic Pharmaceutical Forum.

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In this latest update, we explore some of the key updates in market access over recent months including the UK's voluntary scheme for branded medicines pricing, access and growth (VPAG), the first drugs funded by the Innovative Medicines Fund in the UK and the Direct Access Scheme in France, and, finally, the new Institute for Clinical and Economic Review (ICER) value assessment framework in the USA.

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In this latest update, we explore the Inflation Reduction Act (IRA) enacted by the US Congress in August 2022, with the Centers for Medicare and Medicaid Services (CMS) recently releasing the list of the first ten drugs it will negotiate prices on. We also cover the consequences of price controls and rigid value assessment in Germany which have led to the withdrawal of a number of medicines. It will be important to see how the IRA balances cost-saving with holistic value assessment, incentives for innovation and patient access to treatment.

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Article Synopsis
  • Chronic lymphocytic leukemia (CLL) patients with mutated immunoglobulin heavy-chain genes (IGHV-M) typically respond well to chemoimmunotherapy, especially when lacking poor-risk genetic markers.
  • Researchers classified treatment-naive patients into three DNA methylation subgroups (n-CLL, m-CLL, i-CLL), revealing significant differences in treatment response and survival rates.
  • The study found that the m-CLL subgroup is a strong predictor of longer survival outcomes, indicating its potential role in identifying patients likely to benefit from chemoimmunotherapy.
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Although mentioned in the UK pandemic plan, essential service providers were not among the priority groups. They may be important targets of future influenza pandemic vaccination campaigns. Therefore, we conducted a cross-sectional survey among 380 employees from West Midlands police headquarters and 15 operational command units in the West Midlands Area during December 2009-February 2010 to identify factors affecting intention to accept the pandemic influenza A (H1N1) vaccine.

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