Publications by authors named "Alice B Liu"
Article Synopsis
- Huntington's disease (HD) may impact not just motor function but also the autonomic nervous system, affecting bladder, bowel, and sexual functions.
- A study with 48 HD patients revealed that 93.8% experienced symptoms in at least one of these areas, with over 39% reporting issues across all three.
- Patients with concurrent symptoms tended to have a longer disease duration and lower overall functional capacity.
Longitudinal changes in symptom-based female and male LUTS clusters.
Neurourol Urodyn
January 2020
Article Synopsis
- The study focused on analyzing changes in lower urinary tract symptoms (LUTS) over a year, using data from the LURN Observational Cohort study to identify symptom clusters and treatment impacts.
- Results showed that a significant percentage of both men and women experienced symptom improvement over time, but the extent of improvement varied depending on the symptom cluster.
- The findings suggest that different treatment responses among LUTS subtypes could inform future targeted treatments for patients, highlighting the need for personalized approaches.
Article Synopsis
- The study investigates factors affecting individuals who still experience bothersome lower urinary tract symptoms (LUTS) despite receiving treatment.
- Conducted over a year with 756 participants from six care centers, the research utilized the AUA-SI tool to measure symptom bother levels at the beginning and after 12 months.
- Results indicated that factors like race, diabetes, prior treatments, depression, and psychological stress significantly impacted symptom bother, suggesting these insights could improve clinical care for patients dealing with LUTS.
Purpose: To improve the potential for finding clinically important subtypes of patients with lower urinary tract symptoms we developed the CASUS (Comprehensive Assessment of Self-reported Urinary Symptoms). We used it to present data on the experiences of lower urinary tract symptoms in treatment seeking women and men from a prospective observational cohort.
Materials And Methods: We created an initial list of lower urinary tract symptoms that were confirmed in 22 qualitative interviews with providers, and 88 qualitative interviews with care seeking and noncare seeking women and men with lower urinary tract symptoms.
The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations.
Contemp Clin Trials
November 2018
The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are associated with abnormal lower urinary tract symptoms (LUTS) in patients with overactive bladder syndrome (OAB). The NIST Study tests the hypotheses that patients with urinary urgency will demonstrate: (1) abnormal functional and structural connectivity of brain regions involved in urinary sensation on magnetic resonance imaging (MRI), and (2) hypersensitivity to painful (pressure) and non-painful (auditory) sensory stimuli on quantitative sensory testing (QST), compared to controls. Male and female adults (18 years or older) who present at one of the six participating LURN clinical centers for clinical care of their LUTS, with symptoms of urinary urgency with or without urgency urinary incontinence, are eligible to participate.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate pelvic floor symptoms in women with lower urinary tract symptoms (LUTS), comparing those with urinary incontinence (UI) to those without.
- Researchers collected data from 510 women at several healthcare centers, using specific questionnaires to assess various pelvic floor issues like bowel symptoms and sexual dysfunction.
- Results showed that women with UI reported more bowel issues and worse sexual function, particularly those with mixed urinary incontinence (MUI) who had the most severe symptoms compared to other types of UI.
Purpose: Despite its established efficacy in reducing recurrence rates for patients with urothelial carcinoma, immediate intravesical chemotherapy is reportedly used infrequently. Accordingly, the Urological Surgery Quality Collaborative implemented a project aimed at understanding and improving the use of immediate intravesical chemotherapy.
Materials And Methods: Surgeons in 5 Urological Surgery Quality Collaborative practices prospectively collected clinical and baseline intravesical chemotherapy use data for patients undergoing bladder biopsy or transurethral bladder tumor resection from September 2010 through January 2012.