Publications by authors named "Alexander Christ"

Introduction: Myxoid liposarcoma (MLS) is the second most common liposarcoma, representing 6% of adult soft-tissue sarcomas. This study examines differences in treatment types and survival outcomes by income and rurality in MLS patients.

Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results database for MLS patients from 2000 to 2021.

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Technological advancements in orthopaedic oncology continue to augment our approach to surgical interventions. However, the impact on patient outcomes following lower extremity bone tumor resections remains under-characterized. This systematic review identifies the impact of various technological advancements on post-operative outcomes.

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Background And Objectives: Previous studies evaluating socioeconomic status (SES) in bone malignancies such as chondrosarcoma used the Cox Proportional Hazards model, which might overestimate risk compared to cause-specific models like the Fine-Gray model. This study aims to evaluate the prognostic significance of income status in chondrosarcoma using both models.

Methods: We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed with chondrosarcoma.

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Background And Objectives: Chondroblastoma is a rare, benign bone tumor that affects the epiphyses of long bones in young patients. This study describes the incidence of recurrence in our cohort and its association with adjuvants. Secondary objectives include identifying risk factors for recurrence and the development of angular deformity.

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Patients with resectable Ewing sarcoma (ES) in select sites, such as the pelvis or chest wall, have a higher risk of positive microscopic margins following surgery. AEWS1031 was the first North American/Australasia ES cooperative group trial allowing standardized preoperative radiotherapy, intended to minimize the morbidity of combined modality local tumor control as well as improve the likelihood of clear surgical margins. In this study, we found that the use of low-dose preoperative radiation to a smaller target volume resulted in a high rate of R0 resection.

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Background: The two-stage surgical protocols used for the treatment of periprosthetic joint infection following total knee arthroplasty are associated with marked patient morbidity. As such, alternatives, such as durable "1.5-stage" spacer constructs, have gained popularity.

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Background: Revision hip and knee arthroplasty volume continues to rise, and total femur replacement (TFR) remains a key salvage option in patients with extensive bone loss. Prior research has demonstrated mixed results of this procedure, and this study aimed to characterize the outcomes of nononcologic TFR in one of the largest single-center modern series.

Methods: A retrospective analysis was conducted on 23 nononcologic TFR procedures performed on 22 patients between 2012 and 2021.

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Introduction: Vascular injury during acetabular screw fixation is a life-threatening complication of total hip arthroplasty. This study uses three-dimensional computed tomography to (1) measure absolute distance from the external iliac artery (EIA) to the acetabulum, (2) determine available bone stock along the EIA path, and (3) create a novel acetabular vascular risk map.

Methods: A retrospective radiographic study was conducted using three-dimensional CT.

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Introduction: Identifying risk factors for pulmonary embolism (PE) and deep vein thrombosis (DVT) following primary total knee arthroplasty (TKA) may improve risk stratification and guide surgeons in prophylaxis selection. This study aimed to identify factors associated with postoperative venous thromboembolism (VTE) following TKA.

Methods: A national healthcare database was queried for adults who underwent primary, elective TKA from January 1, 2015 to December 31, 2020.

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Article Synopsis
  • This study investigates the rotational alignment of the distal femur during distal femoral replacement surgery, an area where standard references are often lacking.
  • It involved analysis of CT scans from adults, measuring angles related to various anatomical landmarks at different distances from the joint line, revealing distinct patterns of rotation.
  • The findings suggest that while the Whiteside line is a reliable reference for positioning the femoral implant, attention must be paid to other anatomical features to avoid improper internal rotation at higher resection levels.
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  • This study investigates the rates of venous thromboembolism (VTE) among patients undergoing surgery for cancer-related bone fractures while receiving different anticoagulants: enoxaparin, apixaban, rivaroxaban, or aspirin (ASA).
  • Analysis was conducted using patient data from the Premier Healthcare Database between 2015 and 2021, comparing VTE occurrences among the different medication cohorts, with enoxaparin as the control.
  • Results indicated that enoxaparin was associated with lower VTE rates compared to apixaban but higher than those treated with ASA, suggesting that ASA may be a safer option for certain patients with minimal risk factors for VTE post-surgery.
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Article Synopsis
  • Dexamethasone is commonly used in total joint arthroplasty (TJA) to manage pain and reduce nausea, but its safety for diabetic patients isn't well understood.
  • A study analyzed data from 261,474 diabetic patients who underwent primary TJA to compare outcomes between those who received intravenous dexamethasone and those who did not, finding reduced rates of joint infections and sepsis in the dexamethasone group.
  • While dexamethasone use led to fewer infections and shorter hospital stays, it was associated with a higher risk of postoperative hyperglycemia, suggesting a need for careful monitoring in diabetic patients.
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Background And Objectives: The potential impacts of artificial intelligence (AI) chatbots on care for patients with bone sarcoma is poorly understood. Elucidating potential risks and benefits would allow surgeons to define appropriate roles for these tools in clinical care.

Methods: Eleven questions on bone sarcoma diagnosis, treatment, and recovery were inputted into three AI chatbots.

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Background: Two-stage exchange arthroplasty remains the gold standard for treating chronic hip periprosthetic joint infections. However, controversy remains regarding the optimal spacer type, particularly among patients with increased dislocation risk. This study reports on the outcomes of articulating hip spacers utilizing a single constrained-liner design.

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Introduction: As the volume of technology-assisted total hip arthroplasty (THA) increases, there is a need to characterise the outcomes of robotic-assisted (RA) and computer-navigated (CN) THA. The goal of this study was to assess outcomes and opioid consumption following CN-THA and RA-THA compared to conventionally-instrumented (CON) THA.

Methods: The Premier Database was queried for all patients who underwent primary, elective THA from 2015-2020.

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Introduction: The relationship between surgeon volume and risk of dislocation after total hip arthroplasty (THA) is debated. This study sought to characterize this association and assess patient outcomes using a nationwide patient and surgeon registry.

Methods: The Premier Healthcare Database was queried for adult primary elective THA patients from January 1, 2016, to December 31, 2019.

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: Peripheral nerve injury (PNI) following revision total hip arthroplasty (rTHA) can be a devastating complication. This study assessed the frequency of and risk factors for postoperative PNI following rTHA. Patients who underwent rTHA from 2003 to 2015 were identified using the National Inpatient Sample (NIS).

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Background: Inpatient total hip arthroplasty (THA) and total knee arthroplasty (TKA) practices were dramatically affected in the United States in 2020 as elective surgeries were paused in response to the COVID-19 pandemic. This study sought to provide an updated estimate of inpatient total joint arthroplasty (TJA) case volumes in the United States in 2020.

Methods: A retrospective cohort study was performed by identifying all adult patients who underwent primary, elective TJA from January 1st, 2017 to December 31st, 2020, using the National Inpatient Sample.

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Aims: Modular dual-mobility (DM) articulations are increasingly used during total hip arthroplasty (THA). However, concerns remain regarding the metal liner modularity. This study aims to correlate metal artifact reduction sequence (MARS)-MRI abnormalities with serum metal ion levels in patients with DM articulations.

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Background And Objectives: This study aimed to evaluate the postoperative complications associated with administering intravenous (IV) tranexamic acid (TXA) in patients undergoing surgical fixation for neoplastic pathologic fractures of the lower extremities.

Methods: Patients ≥18 years old who underwent surgical intervention for neoplastic pathologic lower extremity fractures from 2015 to 2021 were identified using the Premier Healthcare Database. This cohort was divided by TXA receipt on the index surgery day.

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Background: This study aims to compare indications, patient characteristics, hospital factors, and complication rates between total hip arthroplasty (THA) patients aged 30 years or younger and those older than 30 years using a large national database.

Methods: The Premier Healthcare Database was utilized to identify primary THA patients from 2015 to 2021 who were aged ≤30 or >30 years. Patient demographics, hospital factors, and primary indications were compared for each cohort.

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Background: Femoral diaphyseal reconstructions with metal prostheses have mediocre results because of high mechanical forces that result in eventual implant failure. Biological alternatives require prolonged restrictions on weight-bearing and have high rates of infection, nonunion, and fracture. A novel method of utilizing a vascularized fibula in combination with an intercalary prosthesis was developed to complement the immediate stability of the prosthesis with the long-term biological fixation of a vascularized fibular graft.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in multimodal pain control following total joint arthroplasty (TJA). However, few studies have assessed the complications associated with the combinations of NSAIDs in this population despite the known risks associated with this class of medications. The Premier Healthcare Database was queried to identify adults who underwent primary total hip or knee arthroplasty from 2005-2014.

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