Publications by authors named "Brandon Gettleman"

Introduction: Myxoid liposarcoma (MLS) is the second most common liposarcoma, representing 6% of adult soft-tissue sarcomas. This study examines differences in treatment types and survival outcomes by income and rurality in MLS patients.

Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results database for MLS patients from 2000 to 2021.

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Technological advancements in orthopaedic oncology continue to augment our approach to surgical interventions. However, the impact on patient outcomes following lower extremity bone tumor resections remains under-characterized. This systematic review identifies the impact of various technological advancements on post-operative outcomes.

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Background And Objectives: Previous studies evaluating socioeconomic status (SES) in bone malignancies such as chondrosarcoma used the Cox Proportional Hazards model, which might overestimate risk compared to cause-specific models like the Fine-Gray model. This study aims to evaluate the prognostic significance of income status in chondrosarcoma using both models.

Methods: We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed with chondrosarcoma.

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Background And Objectives: Chondroblastoma is a rare, benign bone tumor that affects the epiphyses of long bones in young patients. This study describes the incidence of recurrence in our cohort and its association with adjuvants. Secondary objectives include identifying risk factors for recurrence and the development of angular deformity.

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Background: Highly porous metaphyseal cones have emerged as a promising fixation strategy to address extensive proximal tibial bone loss in the multiply revised knee. Despite a paucity of literature regarding stacked cone constructs, they have gained popularity. This study reports on the early outcomes of stacked tibial cone constructs that are used during revision total knee arthroplasty (TKA).

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Background: The two-stage surgical protocols used for the treatment of periprosthetic joint infection following total knee arthroplasty are associated with marked patient morbidity. As such, alternatives, such as durable "1.5-stage" spacer constructs, have gained popularity.

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Article Synopsis
  • This study investigates the rates of venous thromboembolism (VTE) among patients undergoing surgery for cancer-related bone fractures while receiving different anticoagulants: enoxaparin, apixaban, rivaroxaban, or aspirin (ASA).
  • Analysis was conducted using patient data from the Premier Healthcare Database between 2015 and 2021, comparing VTE occurrences among the different medication cohorts, with enoxaparin as the control.
  • Results indicated that enoxaparin was associated with lower VTE rates compared to apixaban but higher than those treated with ASA, suggesting that ASA may be a safer option for certain patients with minimal risk factors for VTE post-surgery.
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Study Design: Systematic review and meta-analysis.

Objective: To compare radiographic outcomes across lumbar interbody fusion (LIF) techniques, assessing segmental and global lumbar lordosis restoration.

Summary Of Background Data: LIF is a commonly utilized procedure to treat various spinal conditions, including degenerative pathology and adult spinal deformity.

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Background: The perioperative use of dexamethasone in diabetic patients remains controversial due to concerns related to infection and adverse events. This study aimed to determine whether clinical evidence supports withholding dexamethasone in diabetic patients due to concern for infection risk. We hypothesized that there is no difference in infectious outcomes between dexamethasone-treated patients and controls.

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Introduction: As the volume of technology-assisted total hip arthroplasty (THA) increases, there is a need to characterise the outcomes of robotic-assisted (RA) and computer-navigated (CN) THA. The goal of this study was to assess outcomes and opioid consumption following CN-THA and RA-THA compared to conventionally-instrumented (CON) THA.

Methods: The Premier Database was queried for all patients who underwent primary, elective THA from 2015-2020.

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Objective: The present study compares postoperative outcomes between patients with and without sickle cell disease (SCD) undergoing 1-to 3-level lumbar spinal fusion for degenerative pathologies.

Methods: Patients who underwent 1-to 3-level lumbar spinal fusion for degenerative pathologies from 2010 to 2021 were identified using the PearlDiver database. Patients were separated into 1) SCD and 2) non-SCD groups and were propensity-matched 1:1 for age, sex, Elixhauser Comorbidity Index, surgical approach, and various comorbidities.

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Article Synopsis
  • The systematic review and meta-analysis aimed to examine how osteoporosis affects outcomes in patients with lumbar degenerative spine disease after surgery, focusing on complications and recovery.
  • Findings indicated that patients with osteoporosis had higher rates of adjacent segment disease and cage subsidence but had lower reoperation rates compared to non-osteoporotic patients.
  • Although osteoporosis was linked to increased complications like longer hospital stays and higher costs, it did not show a significant impact on overall clinical outcomes or fusion rates.
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Introduction: The relationship between surgeon volume and risk of dislocation after total hip arthroplasty (THA) is debated. This study sought to characterize this association and assess patient outcomes using a nationwide patient and surgeon registry.

Methods: The Premier Healthcare Database was queried for adult primary elective THA patients from January 1, 2016, to December 31, 2019.

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Article Synopsis
  • Dexamethasone (DEX) is a medicine that may help reduce blood clots after knee or hip surgery in patients with a history of blood clots.
  • A study looked at over 70,000 patients who had this surgery, comparing those who received DEX with those who didn't.
  • Patients who took DEX had fewer blood clots and shorter hospital stays, but there were no differences in infections between the two groups.
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Study Design: Systematic Review.

Objectives: While substantial research has explored the impact of osteoporosis on patients undergoing adult spinal deformity (ASD) correction, the literature remains inconclusive. As such, the purpose of this study is to synthesize and analyze existing studies pertaining to osteoporosis as a predictor of postoperative outcomes in ASD surgery.

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: Peripheral nerve injury (PNI) following revision total hip arthroplasty (rTHA) can be a devastating complication. This study assessed the frequency of and risk factors for postoperative PNI following rTHA. Patients who underwent rTHA from 2003 to 2015 were identified using the National Inpatient Sample (NIS).

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Background And Objectives: This study aimed to evaluate the postoperative complications associated with administering intravenous (IV) tranexamic acid (TXA) in patients undergoing surgical fixation for neoplastic pathologic fractures of the lower extremities.

Methods: Patients ≥18 years old who underwent surgical intervention for neoplastic pathologic lower extremity fractures from 2015 to 2021 were identified using the Premier Healthcare Database. This cohort was divided by TXA receipt on the index surgery day.

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Background: This study aims to compare indications, patient characteristics, hospital factors, and complication rates between total hip arthroplasty (THA) patients aged 30 years or younger and those older than 30 years using a large national database.

Methods: The Premier Healthcare Database was utilized to identify primary THA patients from 2015 to 2021 who were aged ≤30 or >30 years. Patient demographics, hospital factors, and primary indications were compared for each cohort.

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Article Synopsis
  • The growing elderly population is facing challenges due to osteoporosis, which affects bone strength and can lead to complications in cervical spine surgeries.
  • A systematic review evaluated postoperative outcomes for patients with cervical degenerative disease or deformity, focusing on factors like bone density and complication rates.
  • Results indicated that lower bone mineral density in osteoporotic patients is linked to higher rates of equipment failure and increased risk of complications, although the impact on other surgical outcomes is mixed.
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  • The study examines trends in long-term opioid (LTO) and nonsteroidal anti-inflammatory drug (LTN) use among patients with low back pain in the U.S. and the impact on postoperative complications after lumbar fusion surgery.
  • A rise in LTO usage and a decline in LTN usage were noted post-2015, with LTO users facing higher inpatient costs and longer hospital stays, while LTN users experienced fewer acute infections and complications at admission.
  • Overall, LTN users had lower readmission rates compared to LTO users, but higher odds of hardware failure were noted in LTN users within 300 days post-surgery.
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Background: Hyperglycemia has been identified as a risk factor for periprosthetic joint infection (PJI) after total hip arthroplasty (THA). However, there is no consensus with regard to the preoperative blood glucose level (BGL) on the day of the surgical procedure associated with increased risk. We sought to identify preoperative BGL thresholds associated with an increased risk of PJI.

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Background: Peripheral nerve injury (PNI) following revision total knee arthroplasty (rTKA) is a potentially devastating injury for patients. This study assessed the frequency of and risk factors for postoperative PNI following rTKA.

Methods: Patients who underwent rTKA from 2003 to 2015 were identified using the National Inpatient Sample.

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Article Synopsis
  • * Out of 129 patients, there was no significant difference in recurrence rates between those who received surgical adjuvants and those who did not, with overall recurrence rates of about 25%.
  • * The study also found that younger patients (under 6 years) had a higher likelihood of recurrence compared to older patients, suggesting age may be a more significant factor than the use of adjuvants.
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Medicare Advantage healthcare plans may present undue impediments that result in disparities in patient outcomes. This study aims to compare the outcomes of patients who underwent STS resection based on enrollment in either traditional Medicare (TM) or Medicare Advantage (MA) plans. The Premier Healthcare Database was utilized to identify all patients ≥65 years old who underwent surgery for resection of a lower-extremity STS from 2015 to 2021.

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