Cell cycle dynamics analysis of drug-tolerant persister cells in non-small cell lung cancer.

Molecular-targeted therapy remains effective in cancer treatment; however, drug resistance inevitably arises after prolonged administration for several years. Drug-tolerant persister cells (DTPs), which are subpopulations of cells derived from drug-sensitive cells that develop tolerance after short-term exposure (lasting days or weeks) to drugs, have gained substantial attention. However, the specific characteristics of DTPs remain unclear as they encompass a diverse cell population, although they generally exhibit low proliferative potential.

Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines.

Among triple-negative breast cancer (TNBC) subtypes, the basal-like 2 (BL2) subtype shows the lowest survival rate and the highest risk of metastasis after treatment with chemotherapy. Research has shown that αB-crystallin (CRYAB) is more highly expressed in the basal-like subtypes than in the other subtypes and is associated with brain metastasis in TNBC patients. We therefore hypothesized that αB-crystallin is associated with increased cell motility in the BL2 subtype after treatment with chemotherapy.