Hamamelitannin from Hamamelis virginiana Attenuates Ethanol-Induced Oxidative and Inflammatory Responses in Danio rerio Larvae.

Alcoholic liver disorder (ALD) is one of the most prevalent hepatic ailments worldwide, with oxidative stress and inflammation playing a vital role in disease progression. The current study intended to assess the anti-inflammatory nature of Hamamelitannin (HAM), a gallotannin from Hamamelis virginiana barks, which was predicted to possess anti-inflammatory properties based on in-silico docking analysis. To further explore its effects, we examined the therapeutic effect of HAM against ethanol-mediated inflammation using an in-vivo zebrafish larvae model.

Auramine O, food dye induces cognitive impairment, anxiety, alters synaptic transmission and neural growth in zebrafish model.

Synthetic food dyes, widely used to enhance the visual appeal of food and beverages, are associated with potential neurobehavioral impacts, particularly in children. Despite its banned status in many regions, Auramine O (AO) has been detected as a contaminant in various food products. In silico studies have demonstrated that AO can induce neurotoxic effects.

Thermo stable ZnO NPs/Asiatic acid nanocomposites for acidogenic neutralization, anti-biofilm, and enamel protection in dental enamel reinforcement.

Objectives: Dental caries, a pervasive oral health issue, is driven by Streptococcus mutans-mediated biofilm formation and acidogenesis, culminating in enamel demineralization and structural degradation. This study evaluates the efficacy of thermostable ZnO NPs/AA nanocomposites in suppressing S.mutans acid production, disrupting its biofilm matrix, and strengthening enamel integrity, with an emphasis on its potential as a novel dental healthcare material.

Functionalized Zinc Oxide Nanoparticles Conjugated With Artemisinin Against Luperox-Induced Oxidative Stress and Their Impact on Antioxidant Defense Mechanism.

Reactive oxygen species (ROS) are the by-products of energy metabolism, which play various key roles in the body's metabolism. However, excessive ROS production may contribute to several diseases. Reports suggest that the functional properties of the nanoparticles can be altered by conjugating a plant's secondary metabolite.

Effectiveness of 6-nitrobenzo[d]thiazol-2-amine derivative (N2) in ameliorating ethanol-induced fatty liver through lipogenesis inhibition and anti-inflammatory expression in a zebrafish model.

This study examines the effectiveness of the 6-nitrobenzo[d]thiazol-2-amine derivative (N2) in mitigating the effects of ethanol-induced fatty liver disease in zebrafish by assessing its anti-inflammatory, antioxidant, and antihyperlipidemic properties. The investigation encompasses the evaluation of N2 derivatives on hemolysis, cytotoxicity, developmental toxicity, oxidative stress, and lipid metabolism within zebrafish models. Antioxidant assays highlighted N2's significant radical scavenging activity.

Evaluating the antioxidant-mediated neuroprotection of hamamelitannin against H₂O₂-induced oxidative damage.

Excessive generation of free radicals disrupts redox equilibrium, inducing oxidative stress. Dementia and other related neurodegenerative illnesses are important ailments associated with oxidative stress. Antioxidant treatment proves effective in reducing oxidative stress and associated neurodegeneration.

In Vitro and In Silico Evaluation of the Antioxidant and Anticancer Potential of Hamamelitannin from Hamamelis virginiana.

Oxidative stress, caused by an imbalance between harmful prooxidants and the body's natural antioxidant defenses, plays a major role in the development of cancer. Plant-based compounds, especially polyphenols, are being widely explored for their ability to fight oxidative damage and support cancer therapy. Hamamelitannin (HAM), a natural gallotannin found in Hamamelis virginiana, has shown promising biological activity, but its effects on oxidative stress and cancer are not yet well understood.

Efficacy of 6-nitrobenzo[d]thiazol-2 Amine Derivative (N3) in Mitigating PTZ-Induced Epileptic Conditions Via Modulation of Inflammatory and Neuroprotective Pathways in-vivo Zebrafish.

Epilepsy, a chronic neurological illness affecting 50 million people worldwide, causes recurring seizures due to abnormal brain activity. Current anti-epileptic medications have serious side effects and low efficacy, requiring alternative treatments. The current study investigated the anti-inflammatory, antioxidant, and neuroprotective effects of 6-nitrobenzo[d]thiazol-2-amine (N3) derivatives in a zebrafish larvae model of epilepsy caused by 6 mM pentylenetetrazole (PTZ).

The impact of climate, weather, seasonal transitions, and diurnal rhythms on gut microbiota and immune homeostasis.

The influence of meteorological environmental factors such as climate change, weather alterations, seasonal transitions, and diurnal cycles on human health is becoming increasingly evident, particularly through their modulation of the gut microbiome and immune homeostasis. The human gut microbiota maintains immune homeostasis and regulates various physiological and metabolic functions by producing metabolites like short-chain fatty acids (SCFAs), bile acids (BAs), indole derivatives (IDs), choline metabolites (CMs), and bacterial vitamins (BVs). Climate change disrupts this gut microbiome's impact through the gut-liver axis, which has been linked to the occurrence of fatty liver diseases.

Triclosan promotes neurotoxicity in diabetic conditions: an in vivo molecular assessment using zebrafish model.

Unlabelled: The widespread environmental presence of triclosan (TC), a common antimicrobial agent, has raised concerns about its potential metabolic and neurological effects, particularly in susceptible populations such as individuals with diabetes. This study investigated the neuronal effects of TC in streptozotocin (STZ)-induced diabetic zebrafish larvae using network pharmacology, toxicity assays, and gene expression analysis. Network pharmacology identified 99 overlapping diabetes-related targets, with KEGG analysis implicating AGE-RAGE signaling and cholinergic synapse pathways in diabetic and neuronal complications.

Green Synthesis of Zinc Oxide Nanoparticles for Sustainable Antibacterial, and Mosquito Control and their Toxicity to non-target Organisms.

Mosquito-borne diseases such as dengue, malaria, and filariasis have become serious global health concerns due to their contagious nature and widespread prevalence. In this study, ZnO NPs biosynthesized using the seagrass extract of (CS-ZnO NPs) were prepared from the leaf part and evaluated for their toxicity potential against the larvae, pupae, and adults of various mosquito species, including , , and . The CS-ZnO NPs were characterized using UV-Vis spectroscopy, XRD, FTIR, FE-SEM, EDX, and zeta potential analyses.

SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model.

Alzheimer's disease (AD) and Alzheimer's dementia (ADM) are common neurodegenerative disorders marked by progressive cognitive decline, memory impairment, and behavioral deficits, which impose a significant burden on individuals and healthcare systems worldwide. Due to the complex nature of AD pathophysiology, effective treatment strategies may require targeting multiple pathways. This study explored the neuroprotective effects of the chalcone derivative SG06 in a scopolamine-induced AD-like zebrafish model using network pharmacology and molecular docking.

Protective Effect of Artemisinin Against Luperox Induced Oxidative Stress and Insulin Resistance via Pi3k/Akt Pathway in Zebrafish Larvae.

Oxidative stress plays a critical role in the development of insulin resistance (IR), a key factor in metabolic disorders such as diabetes. Plant active ingredients play a crucial role in protecting organisms from environmental stressors and have shown promising therapeutic potential against various metabolic disorders. Artemisinin (ART), a sesquiterpenoid with a lactone ring obtained from the herb Artemisia annua, exhibits promising therapeutic properties.

Exploring the potential of bacterial-derived EVs for targeted enzyme replacement therapy: mechanisms, applications, and future directions.

Extracellular vesicles (EVs) are membrane-bound vesicles produced by cells which promote intercellular communication by delivering different contents such as DNA, RNA, and proteins. These vesicles, nano-sized and released into the extracellular space, are present everywhere under both normal and pathological conditions. Probiotic-derived EVs can serve as nanocarriers for therapeutic cargo, particularly in enzyme replacement therapy (ERT).

Neurotoxic effects of chronic exposure to perfluorobutane sulfonate in adult zebrafish (Danio Rerio).

Per and polyfluoroalkyl substances (PFAS) are synthetic compounds extensively utilized in industrial applications and consumer products. Long-chain PFAS has been linked to negative health impacts, prompting the introduction of shorter-chain alternatives like perfluorobutane sulfonate (PFBS). While long-chain PFAS are known to induce oxidative stress, neuroinflammation, and neuronal apoptosis, the neurotoxic potential of short-chain PFAS like PFBS was not well studied.

Role of OX/OXR cascade in insomnia and sleep deprivation link Alzheimer's disease and Parkinson's disease: Therapeutic avenue of Dual OXR Antagonist (DORA).

Sleep plays a role in the elimination of neurotoxic metabolites that are accumulated in the waking brain as a result of neuronal activity. Long-term insomnia and sleep deprivation are associated with oxidative stress, neuroinflammation, amyloid beta (Aβ) deposition, and Lewy body formation, which are known to increase the risk of mild cognitive impairment (MCI) and dementia. Orexin A (OXA) and orexin B (OXB), two neuropeptides produced in the lateral hypothalamus, are known to influence the sleep-wake cycle and the stress responses through their interactions with OX receptor 1 (OX1R) and OX receptor 2 (OX2R), respectively.