The impact of climate, weather, seasonal transitions, and diurnal rhythms on gut microbiota and immune homeostasis.

The influence of meteorological environmental factors such as climate change, weather alterations, seasonal transitions, and diurnal cycles on human health is becoming increasingly evident, particularly through their modulation of the gut microbiome and immune homeostasis. The human gut microbiota maintains immune homeostasis and regulates various physiological and metabolic functions by producing metabolites like short-chain fatty acids (SCFAs), bile acids (BAs), indole derivatives (IDs), choline metabolites (CMs), and bacterial vitamins (BVs). Climate change disrupts this gut microbiome's impact through the gut-liver axis, which has been linked to the occurrence of fatty liver diseases.

Host-Parasite Interactions and Integrated Management Strategies for Ecytonucleospora Hepatopenaei Infection in Shrimp.

Background: Ecytonucleospora hepatopenaei (EHP) is a major parasitic pathogen in shrimp causing hepatopancreatic microsporidiosis, which leads to significant growth retardation and global economic losses. This pathogen employs various immune evasion strategies that complicate treatment and management.

Purpose: This review examines the complex host-parasite interactions, focusing on the immune evasion mechanisms used by EHP.

Hydroxyl chalcone derivative DK02 as a multi-target-directed ligand for Alzheimer's disease: A preclinical study in zebrafish.

Background And Purpose: Alzheimer's disease (AD) is a widespread neurodegenerative condition characterized by amyloid-beta (Aβ) plaques and tau protein aggregates, leading to significant cognitive decline. Existing treatments primarily offer symptomatic relief, underscoring the urgent need for novel therapies that address multiple AD pathways. This study evaluates the efficacy of DK02, a hydroxyl chalcone derivative, in a scopolamine-induced dementia model in zebrafish, hypothesizing that it targets several neurodegenerative mechanisms simultaneously.